Основным таргетным белком нестероидных противовоспалительных препаратов (НПВП) является циклооксигеназа 2 (ЦОГ2),

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Objective: to carry out a systematic computer-assisted analysis of scientific literature on on the relationships between the effects of vitamin and nociception (including the impact of vitamin D deficiency on the development of pain syndrome.Material and methods. For the query “(pain OR nociception) AND (vitamin D OR cholecalciferol OR VITD OR CALCITRIOL OR HYDROXYVITAMIN OR DIHYDROXYVITAMIN OR ALPHACALCIDOL)", 2318 references, including 77 references on alpha-calcidol, were found in the biomedical publications database PubMed. The computer-assisted analysis of this array of publications was carried out using the current big data analysis methods developed within the topological and metric approaches to recognition/classification problems.Result and discussion. A systematic computer-assisted text analysis of 2318 studies on the relationships between nociception and vitamin D showed that the analgesic effects of the vitamin are by anti-inflammatory action and the regulation of serotonergic, dopaminergic, and opioidergic neurotransmission. The lower blood levels of the major vitamin D metabolite 25 (OH)D is a risk factor for decreased pain threshold in myalgia, fibromyalgia, arthralgia, dorsalgia, and a number of neuralgias.Conclusion. In patients with impaired renal conversion of active vitamin D metabolites (especially in the elderly), the efficacy of cholecalciferol-based drugs is reduced, which makes it necessary to use the active forms of vitamin D.

The results of the study suggest neuroprotective, sedative and antidepressive properties of magnesium pyroglutamate which are realized by pyroglutamate-anion in the synergism with magnesium cation.

Currently, the system of accounting and monitoring of greenhouse gas emissions is being formed in the Russian Federation. It should be noted that within the framework of the system being formed, the transport sector is considered as the main contributor that generates large amounts of greenhouse gas emissions in cities and on busy federal highways. At the same time, it is proposed to take into account emissions directly when burning fuel only by road, city electric, rail, water and air transport. The article discusses methods for estimating gross emissions from road facilities using data mining methods aimed at verifying the results obtained. The article also presents the calculation of greenhouse gas emissions for road facilities in the pilot region with a description of the verification algorithm for the results obtained. The results of testing the methods for determining greenhouse gas emissions by road facilities showed that this calculation method can be used in estimating greenhouse gas emissions at road facilities, however, reliable baseline data for calculating gross greenhouse gas emissions can only be obtained by analyzing the activities of economic entities in transport and in the road sector. It should be borne in mind that business entities are not obliged to provide information constituting commercial secrets from their point of view. Therefore, the results obtained are of an estimated nature and relate only to those objects, data on which could be obtained from official statistics and free sources, while the actual amount of greenhouse gas emissions from road facilities in the pilot region during the period under review may be significantly higher.