Учредитель и издатель: Founder and editor: ФГБОУ ВО «Казанская государственная академия ветеринарной медицины имени Н.Э. Баумана» (ФГБОУ ВО Казанская ГАВМ) FSBEI HE «Kazan Bauman State Academy of Veterinary Medicine»(FSBEI HE KSAVM) Печатается по решению редакционной коллегии Казанской государственной академии ветеринарной медицины им. Н.Э. Баумана от 5 Сентября 2019 г

Êëþ÷åâûå ñëîâà: ëåéêîç êðóïíîãî ðîãàòîãî ñêîòà, âèðóñ ëåéêîçà êðóïíîãî ðîãàòîãî ñêîòà (ÂËÊÐÑ), ãåìàòîëîãè-÷åñêèå è ñåðîëîãè÷åñêèå èññëåäîâàíèÿ, ðåàêöèÿ èììóíîäèôôóçèîííîé ïðåöèïèòàöèè (ÐÈÄ), Ðåñïóáëèêà Äàãåñòàí. Key words: leucosis of cattle, bovine leukemia virus (BLV), hematologic and serologic studies, immunoprecipitation test (AGID), Dagestan Republic. Ðåçþìå. Ëåéêîç êðóïíîãî ðîãàòîãî ñêîòà ñ 1988 ïî 2017 ãã. ðåãèñòðèðóåòñÿ ïðîäîëaeèòåëüíîå âðåìÿ â áîëüøèíñòâå õîçÿéñòâ Ðåñïóáëèêè Äàãåñòàí ñðåäè âñåõ ïîëîâîçðàñòíûõ è ïðîèçâîäñòâåííûõ ãðóïï ñ òåíäåíöèåé ê øèðîêîìó ðàñïðîñòðàíåíèþ. Ïîëó÷åííûå äàííûå ñâèäåòåëüñòâóþò îá îñîáåííîñòÿõ è çàêîíîìåðíîñòÿõ ðàçâèòèÿ è ïðîÿâëåíèÿ èíôåêöèîííîãî è ýïèçîîòè÷åñêîãî ïðîöåññîâ èíôåêöèè âèðóñà ëåéêîçà êðóïíîãî ðîãàòîãî ñêîòà (ÂËÊÐÑ), ÷òî îáóñëàâëèâàåò ñïåöèôèêó ïðîâåäåíèÿ ïðîòèâîëåéêîçíûõ ìåðîïðèÿòèé â ðåñïóáëèêå. Òàê, çà ïîñëåäíèå 9 ëåò îáñëåäîâàíèÿ â ÐÈÄ 8,9 (6,7-12,2) òûñ. ãîëîâ êðóïíîãî ðîãàòîãî ñêîòà åaeåãîäíî âûÿâëÿþò 1,2 (0,4-2,4) òûñ. ïîëîaeèòåëüíî ðåàãèðóþùèõ aeèâîòíûõ, ÷òî ñîñòàâëÿåò 13,5% îò ÷èñëà èññëåäîâàííûõ. Ïîêàçàòåëü èíôèöèðîâàííîñòè åaeåãîäíî ïîääåðaeèâàëñÿ íà óðîâíå 6,5-23,6%. Ãåìàòîëîãè÷åñêèì ìåòîäîì èññëåäîâàëè 246,2 aeèâîòíûõ è ñðåäè íèõ åaeåãîäíî âûÿâëÿëè 78,9 (32,1%) áîëüíûõ. Ëåéêîç êðóïíîãî ðîãàòîãî ñêîòà íàíîñèò ñóùåñòâåííûé ýêîíîìè÷åñêèé óùåðá îòðàñëè è òðåáóåò áîëåå àêòèâíîé è ïåðñïåêòèâíîé áîðüáû ñ ýòèì çàáîëåâàíèåì. Äëÿ ýôôåêòèâíîé ðàáîòû ñ ëåéêîçîì êðóïíîãî ðîãàòîãî ñêîòà íåîáõîäèìî ðàçðàáîòàòü Ðåñïóáëèêàíñêóþ öåëåâóþ ïðîãðàììó. Summary. Leucosis of cattle from 1988 till2017 is registered for a long time in the majority of farms of Dagestan Republic among all age and production groups with a tendency to wide distribution. These results indicate that the features and patterns of development and manifestation of infectious and epizootic processes of virus infection of bovine leukemia (BLV), which determines the specifics of the anti-leukemic activities in the republic. So, during last 9 years of study in AGID 8,9(6,7-12,2) thousands of heads of cattle annually show 1,2 (0,4-2,4) thousands of positively reacting animals, which amounts to 13,5% of the surveyed. The infection rate was maintained on6,5-23,6% each

Objective of research: Determination of the efficiency of 5% concentration Diminazene aceturate at the dose of 0.25 mg/kg body in combination with polyethylene glycol solution applied against piroplasmidosis in cattle. Materials and methods: Trial of the new method of prolonged chemoprevention was carried out in one of the farms of Dagestan, which is unfavorable for piroplasmidosis. Aceturate contained in this drug rapidly inhibits DNA in cells of blood parasites, which leads to their death within several hours. Diminazene aceturate proved to be effective against piroplasmidosis, babesiosis, taleriosis, hemosporidosis of animals. The experiment was conducted on 30 head of cattle divided into 3 groups 10 head in each. Animals of two groups received the preparation and prolongator at the dose of 0,25 mg/kg in the 15% aqueous solutions of polyethylene glycols (PEG), and at the dose of 0,25 mg/kg in the 20% aqueous solutions; the third group served as a control (received the preparation without prolongator). Efficacy of the method was estimated by periodic examination of blood smears from experimental animals for plasmodia in erythrocytes and synchronous measurement of body temperature of animals. Results and discussion: It was found that the method of prolonged chemoprophylaxis applied against piroplasmidosis in animals (at the dose of 5 ml per 100 kg body weight, 6 times every 25 days) enables disease prevention during the whole disease season. Such method allows reducing the number of treatments from 24 to 12-13 times in a season. In addition, data on the distribution of hemosporidia infections among the cattle in the Republic of Dagestan were clarified.