Assessment of health-related quality of life in patients with chronic hepatitis C, as a technique for determining the tolerability of complex antiviral therapy.Methods: а comprehensive examination of 106 patients with a diagnosis of chronic hepatitis C was performed before and after the end of the combination antiviral therapy.Results of the study: after therapy on all scales of the physical component of health, higher rates were observed in men. Significantly differences (p < 0.05) were obtained in the following areas: physical functioning (PF), role-based functioning due to physical condition (RP) and general health status (GH). According to the scales of the mental component of health, the indicators of quality of life in men also exceed the obtained values in women, however, significant differences (p < 0.05) are established only on the scale of role-based functioning due to the emotional state (RE).
Проблема хронического гепатита С является одной из самых актуальных в современной медицине. Это не может не касаться детской популяции, которая является наиболее уязвимой. Материалы и методы. Под наблюдением находились 50 детей, проходивших лечение в инфекционной клинической больнице г. Ярославля в возрасте до 18 лет. Результаты. Хронический гепатит С у детей в 56% протекает бессимптомно, и только у 44% пациентов показатели АЛТ превышали норму. Бессимптомное течение ХГС не означает отсутствие прогрессирования заболевания. Эластометрия печени выявила фиброз различной степени выраженности в отсутствии клинических симптомов заболевания. Распределение генотипов у детей соответствовало таковому у взрослых, но чаще, чем у взрослых, выявлялся 2 генотип. Вирусная нагрузка чаще имела минимальный уровень, в отличие от взрослой популяции Ярославской области.
Clinical and epidemiological features of acute viral hepatitis C were studied. It was revealed that the disease more often occurs in the jaundice form of medium degree and severity. In the pre-jaundice period, flu-like syndrome was more common, and arthralgic syndrome was less common. It was found that in 40% of cases, an epidemiologically significant event that led to infection is detected in the anamnesis. People aged 30 to 49 are more likely to get sick. 40% of patients have various comorbidities.
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