ЗНАЧЕНИЕ КОМОРБИДНОСТИ ДЛЯ СТРАТИФИКАЦИИ ЛЕЧЕНИЯ ОСТРЫХ МИЕЛОИДНЫХ ЛЕЙКОЗОВ У ВЗРОСЛЫХ © Н. В. ГоряиноваСмертность при лечении острого миелоидного лейкоза (ОМЛ)

В исследование были включены 584 пациентки с миомой матки и 391 женщина контрольной группы. Генотипирование однонуклеотидных полиморфизмов (SNP) генов HIF1A и HIF1B (rs2301106, rs2301113, rs1951695, rs2057482, rs4899056 HIF1A и rs3738493, rs10847 HIF1B) было проведено методом ПЦР в режиме реального времени. Выявлен протективный эффект rs10847 HIF1B относительно риска развития миомы матки (OR=0,78, 95%CI=0,63-0,95; p=0,016). Обсуждаются молекулярные механизмы связи rs10847 HIF1B с патогенезом миомы матки. A total of 584 patients with uterine fibroids and 391 healthy controls were recruited for the study. Genotyping of single nucleotide polymorphisms (SNPs) of the HIF1A and HIF1B genes (rs2301106, rs2301113, rs1951695, rs2057482, rs4899056 HIF1A and rs3738493, rs10847 HIF1B) was performed using real-time PCR). The protective effect of rs10847 HIF1B against the risk of uterine fibroids was revealed (OR=0.78, 95%CI=0.63-0.95; P=0.016). The molecular mechanisms of the involvement of rs10847 HIF1B to the pathogenesis of uterine fibroids are discussed.

По результатам мониторинга 2002-2020 гг. проанализирован спектр возбудителей инфекционно-воспалительных осложнений (ИВО) у пациентов с острым миелоидным и острым лимфоидным лейкозом. Изолировано 2039 штаммов микроорганизмов, среди которых 306 культур отнесены к этиологическим факторам ИВО. Представлены профили резистентности основных патогенов родов Staphylococcus, Enterococcus, семейства Enterobacteriaceae, дрожжеподобных грибов рода Candida. According to the monitoring results of 2002-2020, the spectrum of causative agents of infectious- inflammatory complications (IIC) in patients with acute myeloid and acute lymphoid leukemia was analyzed. There were isolated 2039 strains of microorganisms, among which 306 cultures were attributed to the etiological factors of IIC. The profiles of resistance of the main pathogens of the genus Staphylococcus, Enterococcus, Enterobacteriaceae family, fungi of the genus Candida are presented.

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The Objective: to determine the relationship between changes in hema tology clinical condition and immunological parameters in patients with myelodysplastic syndrome (MDS).Materials and methods. There were examined 36 patients diagnosed with MDS . All patients were divided into groups depending on the response to treatment : Group 1 – patients before treatment; Group 2 – patients who have responded positively to therapy and became transfusion independent ( remission , partial remission and great hematological response ); Group 3 – patients, gave only a small hematology response and were transfusion dependent, as well as those that have not responded to treatment. The control group included 30 healthy individuals with no bad habits that can affect your blood.Results. The comparative analysis of clinical and hematological data and immunological study of peripheral blood cells and bone marrow in the initial period and in achieving clinical and hematologic compensation in MDS patients with refractory anemia with excess blasts (RANB). Established reduce the number of myeloid progenitor cells in the bone marrow origin in achieving clinical and hematologic compensation that can be considered as one of the criteria prognosis.Conclusion. Results of the study show that with a positive response to treatment of patients with MDS improved clinical and hematological parameters, patients achieved transfusion independence while they watch reducing hematopoietic cells in bone marrow. The dynamics of immunological parameters can be used in evaluating the effectiveness of treatment and prognosis of MDS.