The analysis of the loss of years by YLL (Years of Life Lost) from the mortality of the population in the age and sex aspect of nosology class of diseases of the circulatory system in industrial regions of East Kazakhstan and Karaganda regions of the Republic of Kazakhstan (RK). In the dynamics for 2011–2014, a decrease in mortality was established, which is associated with an increase in the quality of medical care.

Aim. To study epidemiological aspects of disease, class of diseases of the digestive system in the region of the relative risk in Kazakhstan. Materials and methods. Studied epidemiological parameters are first identified in the incidence and prevalence of class XI ICD in regions of Kazakhstan with the identification of risk relative to the average national level. In a dysfunctional region Kyzylorda region analyzed the performance of its regions and compared with data from medical examination of the population and the survey. Results. A significant excess of the average national incidence rate between 1990 and 2015, was noted for 3 of the 14 regions of Kazakhstan (West-Kazakhstan, Kyzylorda, Mangystau). According to the dynamics of the unfavorable situation on the high level of incidence currently is in the Kyzylorda region (COA). From the areas of the COA maximum, the incidence of diseases of the digestive system registered in Kazalinsk district which exceeded the level at RK 4.8 times. The data on examination and survey of the complaints of the population exceeded the epidemiological indicators. In the area identified as the leading neoplasms of the digestive system in the structure of cancer incidence and exceeded the national average on the related class of blood diseases. Unfavorable situation on the incidence of the digestive system in Kyzylorda region of Kazakhstan is associated with the cancer and blood diseases, this is partly due to the presence of pollutants in the environment.

The authors considered changes of peripheral blood parameters in female population exposed to suspended substances (РМ10 and РМ2,5) in ambient air on ecologic disaster territory — Kazakhstan part near Aral sea. RBC changes are revealed, these signs appeared to be prevalent among the females examined, correlation links are strong between the suspended substances (РМ10 and РМ2,5) in the ambient air and the blood parameters.