Самарский государственный медицинский университет; 443079, Россия, Самара, проспект Карла Маркса, д. 165 «б» РезюмеВведение. При лечении пациентов с параректальными свищами довольно часто встречаются рецидивы заболевания, а также послеоперационные осложнения в виде нагноения послеоперационной раны, анальной инконтиненции и т. д. Цель работы -изучить влияние применения антибактериальных препаратов на результат лечения пациентов с параректальными свищами. Материалы и методы. Проведен проспективный анализ 105 случаев лечения пациентов. Все пациенты были разделены на 2 группы методом случайной выборки: в I группе пациентам, помимо стандартной предоперационной подготовки, выполнялась санация свищевого хода 1%-ным раствором диоксидина. В послеоперационном периоде пациентам выполнялись перевязки с мазью диоксидин 5%-ный, а также осуществлялось введение мази per rectum с 1-х послеоперационных суток в течение 7 дней. Во второй группе проводилась стандартная предоперационная подготовка. Всем пациентам групп сравнения интраоперационно брали посев на флору из свищевого хода. В послеоперационном периоде оценивалось заживление послеоперационных ран, стихание местной и системной воспалительной реакции. Результаты. Выявлены статистически значимые различия в полученных результатах посева в группах сравнения, что свидетельствует об эффективности предоперационной санации свищевого хода 1%-ным раствором диоксидина. В послеоперационном периоде исчезновение гиперемии кожных покровов вокруг раны и значительное уменьшение отека мягких тканей отмечалось в I группе в среднем на 4,2 ± 1,8 сут., во II группе -на 5,4 ± 2,6 сут. (t = 0,379, р < 0,05). Применение двухэтапной профилактики послеоперационных осложнений позволяет улучшить результаты лечения пациентов с параректальными свищами за счет снижения количества патогенной микрофлоры в области послеоперационной раны, более быстрого купирования местной и системной воспалительной реакции, а также за счет увеличения количества пациентов с первичным заживлением послеоперационных ран. Выводы. Данная двухэтапная схема профилактики послеоперационных осложнений у пациентов с параректальными свищами с применением 1%-ного раствора диоксидина и мази диоксидин 5%-ной повышает эффективность лечения.
Meckel’s diverticulum is an important issue of modern surgery due to challenges in the diagnosis of its complications. Among them, intestinal bleeding is estimated at 5%. A man with gastrointestinal bleeding of unknown cause was urgently admitted to the surgical department of the Samara State Medical University. Previously, the patient was diagnosed with chronic hepatitis C and decompensated hepatic cirrhosis. Blood tests revealed reduced hemoglobin and RBC, increased WBC, ALAT, and ASAT, and abnormal coagulation. Abdominal ultrasound revealed enlarged liver and intraperitoneal fluid. Esophagogastroduodenoscopy and colonoscopy failed to identify any source of bleeding. Medical therapy was ineffective. Considering recurrent intestinal bleeding, the patient underwent laparotomy. After the dissection of the ileum, a vein of the submucosal layer of Meckel’s diverticulum with fresh blood coming from a defect was detected. Resection of the ileum with diverticulum was performed, intestinal anastomosis was constructed. The postoperative outcome was good. The patient was discharged with relevant recommendations. This observation is rather uncommon. Published papers describe only single cases of intestinal bleedings in patients with decompensated hepatic cirrhosis. KEYWORDS: Meckel’s diverticulum, hepatic cirrhosis, profuse intestinal bleeding, resection of the ileum. FOR CITATION: Katorkin S.E., Bystrov S.A., Andreev P.S. et al. Successful surgery for profuse bleeding from Meckel’s diverticulum in a patient decompensated hepatic cirrhosis. Russian Medical Inquiry. 2021;5(3):162–164. DOI: 10.32364/2587-6821-2021-5-3-162-164.
Target. Comparative assessment of the clinical efficacy of Aescusan I generation phlebotonics application in the complex treatment of patients with CVD.Material and methods. Analysis of treatment of 380 patients who applied for a phlebological appointment at the polyclinic department of SamSMU Clinics for the period from September 2017 to March 2019 was conducted. Group I (n = 104) included patients with even outpatient card numbers who were prescribed Troxevasin as a first-generation phlebotonic according to the scheme recommended by manufacturers Group II (n = 276) included patients with odd outpatient card numbers who were prescribed Aescusan (an extract of horse chestnut seeds Aesculus hippocastanum, active ingredient of which is aescin) as phlebotonics of the first generation according to the scheme recommended by the manufacturers. All patients were examined by a phlebologist before and after 1 course of treatment. Clinical efficacy of the therapy was assessed by the severity of the pain syndrome, feeling of heaviness, swelling and seizures using visual analogue scale (VAS). In addition, the effectiveness of conservative therapy was assessed through interviews and questionnaires. For a comparative assessment of the severity of edema syndrome, the lower limb circumference was measured at ankle level using a graduated tape.Results. No side effects were detected during clinical observation of the use of drugs. After the course of treatment, most of the observations showed positive dynamics. Changes in clinical symptoms (pain, seizures, heavy legs) in Group I were statistically unreliable (p>0.05). In the second group there was a decrease of pain syndrome intensity by 73,2%, a decrease of convulsions - by 63,5%, a decreaseof heaviness feeling – by 73,7%. In the course of the survey, 272 patients (98.5%) of Group II evaluated the treatment results as good, 4 patients (1.5%) did not notice any treatment results.In the course of repeated examination after the treatment 96,5% of doctors noted the result in Group II as good, 3,5% - as satisfactory. Conclusion. Thus, the results of complex treatment of patients with CVD showed that the use of 1st generation phlebotonics should be considered not only as pathogenetically justified, but also effective from the clinical point of view. Application of Aescusan drug leads to statistically significant reduction of clinical symptoms (subjective and objective) of lower limbs CVD.
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