Evaluation of the efficacy of modern wound care dressings in the complex treatment of purulent wounds

Каторкин, С. Е.; Bystrov, S.A.; Лисин, О. Е.; Розанова, А. А.; Безбородов, А. И.

doi:10.21518/1995-1477-2019-1-2-146-152

Stacionarozameshchayushchie tekhnologii: Ambulatornaya khirurgi

2019

DOI: 10.21518/1995-1477-2019-1-2-146-152

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Evaluation of the efficacy of modern wound care dressings in the complex treatment of purulent wounds

С. Е. Каторкин

S.A. Bystrov

О. Е. Лисин

et al.

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Cited by 11 publications

(2 citation statements)

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“…Nowadays, there are certain techniques available, which can help facilitate the wound healing process as well as improve the structural and functional properties of the newly developing tissue. Most of such techniques involve wound coatings that differ in their composition and functional features [4][5][6][25][26][27].…”

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confidence: 99%

“…Given that, there has been a wider use of dressings made with advanced technologies and featuring a set of the following properties: inertia in relation to biological tissues; minimal mechanical trauma potential; impermeability to microorganisms and dust particles; pH control; gas composition and humidity of the environment around the wound. Therefore, one of the major requirements for advanced wound coverings (dressings) implies their maximum action polyvalence [9][10][11].…”

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confidence: 99%

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Preclinical Trials for Advanced Chitosan-Based Coatings in Treating Purulent Wounds

Ushmarov¹,

Gumenyuk²,

Gumenyuk³

et al. 2021

ArveMED

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Wound healing is a complex set of body responses to damaged tissues, which manifests itself through local destructive-inflammatory changes and general reactions. There are numerous coatings used currently in clinical practice to treat wounds. These coatings serve to develop a wet anti-bacterial environment, which is essential to facilitate the healing process. This work focuses on studying multifunctional coatings, which are based on chitosan, a biocompatible polymer featuring wound-healing properties. The distinctive feature to be found in chitosan fibers is their density and the orientation of pores. The coatings within this study were tested on scalped full-layer skin wounds of male Wistar-Kyoto rats and male rabbits. The sample with a dense structure and low biological resorption was found to be effective in performing the function of a framework, as well as in ensuring proper drainage at the affected area. This is important when treating purulent wounds. The experimental sample with a high degree of adhesion and a shorter biodegradation life can be recommended for treating wounds with no purulent-inflammatory issues, for granulating wounds, as well as a drug carrier-matrix. The studied wound coatings have revealed their medical efficiency at the preclinical stage (in vivo). Using wound coatings with specified structural and functional features would allow making a reasonable choice when selecting a coating depending on the stage of wound healing course.

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mentioning

confidence: 99%

mentioning

confidence: 99%

Preclinical Trials for Advanced Chitosan-Based Coatings in Treating Purulent Wounds

Ushmarov¹,

Gumenyuk²,

Gumenyuk³

et al. 2021

ArveMED

View full text Add to dashboard Cite

show abstract

Local management of purulent wounds with wound dressings

Grigoryan¹,

Бежин²,

Панкрушева³

et al. 2022

Khir. Z. im. N.I. Pirogova

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A clinical trial of the efficacy of a combination of antiseptic and antimicrobial agent in the treatment of inflammatory processes of the skin and soft tissue

Grigorian

Бежин

Суковатых

et al. 2021

Issled. prakt. med. (Print)

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Purpose of the study. To conduct a clinical trial of the local treatment efficacy of skin and soft tissue inflammatory processes combination with sodium carboxymethylcellulose, immobilized miramistin and metronidazole.Patients and methods. The study involved patients with purulent-inflammatory skin processes, divided into two groups – control and experimental – 30 in each. The most common nosological form were abscesses of various localization. In the control group, local treatment was carried out with dioxomethyltetrahydropyrimidine ointment with chloramphenicol, and in the experimental group – with a combination of sodium carboxymethylcellulose with miramistin and metronidazole. We studied the local temperature, wound pH, wound planimetry, the appearance of wounds, the species composition of infectious agents in the discharge from the wound, a general blood test (with the determination of leukocyte indices), blood biochemical parameters, and the number of bed-days in the hospital. The data obtained were processed statistically.Results. The percentage of reduction in the area and volume of wounds in the experimental group was significantly higher than in the control. The maximum rate of wound healing in the experimental group was noted on days 1-3 and amounted to 9.7 (6.3; 15.5) % / day, and in the control group – 5.6 (2.9; 7.7). Starting from the 5th day of treatment, the local temperature indices in the experimental group were significantly lower than in the control group, and the pH values of the wounds in the experimental group tended to neutral values from the 5th day of treatment, and in the control group there was an increase in pH. Most often, S. epidermidis and S. aureus were inoculated from the wound discharge (in total, more than 50 % of observations); in the control group, pathogenic microorganisms were inoculated 1.6 times more often than in the experimental group.Conclusion. Patients in the experimental group were hospitalized for 2.5 days less than patients in the control group. It is possible to recommend further study and application of the combination of miramistin and metronidazole immobilized on the sodium salt of carboxymethylcellulose in the treatment of wounds.

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Evaluation of the efficacy of modern wound care dressings in the complex treatment of purulent wounds

Cited by 11 publications

References 1 publication

Preclinical Trials for Advanced Chitosan-Based Coatings in Treating Purulent Wounds

Preclinical Trials for Advanced Chitosan-Based Coatings in Treating Purulent Wounds

Local management of purulent wounds with wound dressings

A clinical trial of the efficacy of a combination of antiseptic and antimicrobial agent in the treatment of inflammatory processes of the skin and soft tissue

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