Известно, что дети с аутизмом плохо поддаются психолого-логопедической коррекции и лекарственному лечению. Актуальный вопрос настоящего времени – выбор альтернативных методов лечения.В статье представлен типичный случай аутизма с учетом анамнеза, психологических характеристик, фармакогенетического тестирования, особенностей ЭЭГ, результатов лабораторных исследований сыворотки крови (BDNF, програнулин, антитела к основному белку миелина, глутамат), оценивается эффективность метода ритмической транскраниальной магнитной стимуляции.У пациента с аутизмом были зарегистрированы высокий уровень антител к общему белку миелина, примерно в 2 раза превышающий верхнюю границу нормы, а также повышенное содержание глутамата в крови, что, предположительно, может отражать патогенетические механизмы данной патологии. Курсовое лечение методом ритмической транскраниальной магнитной стимуляции привело к клиническому улучшению и оказало нормализующее влияние на уровень антител к общему белку миелина и глутамата в сыворотке крови. Степень редукции клинической симптоматики коррелировала с изменением содержания в крови биохимических показателей: глутамата и антител к общему белку миелина. It is known that children with autism do not respond well to psychological and speech correction and drug treatment. The actual question of the present time is the choice of alternative methods of treatment.The article presents a typical case of autism, taking into account the history, psychological characteristics, pharmacogenetic testing, EEG features, the results of laboratory studies of bloodserum (BDNF, progranulin, antibodies to myelin basic protein, glutamate); the effectiveness of the method of rhythmic transcranial magnetic stimulation is evaluated.A patient with autism had a high level of antibodies to total myelin protein, approximately 2 times higher than the upper limit of the norm, as well as the increased content of glutamate in the blood, which, presumably, may reflect the pathogenetic mechanisms of this pathology. The course of treatment with rhythmic transcranial magnetic stimulation led to clinical improvement and had a normalizing effect on the level of antibodies to total myelin protein and glutamate in blood serum. The degree of reduction of clinical symptoms correlated with the changes of biochemical parameters in the blood: glutamate and antibodies to total myelin protein.

Thyroid hormones can affect the cardiovascular system directly by binding to nuclear thyroid receptors, as well as indirectly by changing the neuro – humoral status of the body as a whole. The aim of the work was to assess the effect of levothyroxine suppressive therapy on the regulation of the heart rate and activity of the sympathoadrenal system, as well as the level of cortisol in the blood of young patients with thyroid cancer. It is shown that the effect of suppressive therapy with levothyroxine on the state of the cardiovascular system is manifested in an increase in the risk of tachycardia and changes in heart rate variability associated with the body mass index. Patients with thyroid cancer had a sharp decrease in normetanephrine (norepinephrine metabolite) in the urine. The levels of metanephrine (metabolite of adrenaline) and dopamine in the urine was dependent on the tonus of the autonomic nervous system and blood pressure. The revealed shifts indicate that against the background of subclinical hyperthyroidism, the mechanisms aimed at stabilizing the heart rate and preventing the effects of hyperstimulation of thyroid and beta-adrenoreceptors of the myocardium are included.

Today, the study of autism spectrum disorders is relevant due to a high prevalence, an increase in the frequency of occurrence, as well as due to a lack of the unified concept of their etiology and pathogenesis. The purpose of the work is to conduct a brief review of evolution of the childhood autism ideas, including the pathogenesis issues and a search for possible markers of this disease. A brief information on the historical development of the childhood autism ideas, from the pre-Kanner period until now is presented. The modern pathogenesis theories are considered, including heredity, as well as the impact of adverse environmental factors on the child’s body during prenatal development: toxic effects, inflammatory processes and immune disorders in the mother’s body. Modern pathogenesis theories consider such processes as the disruption of synaptic transmission, metabolic disorders of neurotransmitters and neurospecific proteins, the carriage of antibodies to neurotransmitters and neurospecific proteins, the mitochondrial dysfunction, the peroxidation increase, the connection with gastrointestinal tract diseases and altered microflora. The data presented suggest that childhood autism is a multifactorial disease, and a search for markers should then cover a wide range of parameters, including genetic, immunological, biochemical, and possibly microbiological characteristics of the child’s body.

A comparative analysis of structural organization changes in skin microcirculatory vessels, serum level of leptin, diponectin, resistin in the ase of metabolic syndrome and doxorubicin intoxication was performed. It was shown that hypertrophy of the muscle fibers, perivascular space edema, and skin arteriole spasm in the metabolic syndrome accompanied by a structural reorganization of the organs and their vessels by the type of dystrophy. In the case of doxorubicin intoxication, the alteration processes were dominant. Changes in the level of hormones leptin adiponectin and resistin in the metabolic syndrome and doxorubicin intoxication were multidirectional.

A literature review about the role of microrna in biological processes associated with .obesity was completed. Modern ideas about micrornas, their biogenesis and their role in the formation of adipose tissue, glucose and lipid metabolism were described. The possibilities of using microRNA as new biomarkers and therapeutic targets for development of anti-obesity drugs were considered.