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There has been a shift in medicine from relying on clinical biomarkers to including patient-reported outcome measures. From a healthcare perspective, health-related quality of life (HRQOL) measures can be used to enhance patient care and reducing treatment cost for patients. Given the possible importance of Medical Outcome Study in medicine, and the conflicting reports in literature about its use in healthcare, it is important to identify its utility within the medical community. In this study 150 people were recruited prospectively from patients at the Hospital and the emergency сenter №1 in Zaporizhzhya, Ukraine. Four groups were formed. The inclusion criteria to group were different comorbid pathology of osteoarthrosis. We assessed patients HRQOL SF-36 SF-36 changes before and after pharmacotherapy (over 1 year), than it were compared with the control group. The validity of the construct has been analyzed by discriminant analysis. To assess SF-36 ability identifying discriminating functions were developed, determine its prediction value, define which scales of SF-36 are the best predictors for every groups. In addition, canonical analysis demonstrates SF-36 ability to estimate effect of pharmacotherapy. Statistical analysis show that all indices quality of life through SF – 36 scales except of third (physical role functioning, physical functioning, emotional role functioning) have prognostic value (p>0.05) and validity of SF-39 scales for examination of the patients with coexisting disease is statistically significant(p<0.05).

СОСТОЯНИЕ ЦИТОКИНОВОГО СТАТУСА БОЛЬНЫХ ВЯЛОТЕКУЩИМ ОСТРЫМ ОДОНТОГЕННЫМ ОСТЕОМИЕЛИТОМ ЧЕЛЮСТЕЙ © Н. Г. Баранник, С. Д. Варжапетян Методом твердофазного иммуноферментного анализа (тест-система ООО «Цитокин») определена концентрация цитокинов (ИЛ-1, ФНОα, ИЛ-6, ИЛ-4) в сыворотке крови 21 пациента с острым одонтогенным остеомиелитом челюстей и 21 здоровых лиц. Выявлено достоверное увеличение в сыворотке крови провоспалительных интерлейкинов: ИЛ-6 (22,224±8,244), ИЛ-1β (1,823±0,300), ФНОα (2,752±0,624), и незначительное повышение синтеза противовоспалительного интерлейкина ИЛ-4 (0,462±0,064) Ключевые слова: иммунологический статус, острый одонтогенный остеомиелит челюстей, интерлейкиныThe content of IL-1β in the serum level was 1,823±0,300 (p<0.001), which is approximately 14.7 times the value of this indicator in healthy individuals -control group (0,124±0,026). The concentration of TNFα in the blood of healthy individuals was 0,196±0,023, while in patients with acute odontogenic osteomyelitis occurs without acute clinical symptoms, observed an increase in the corresponding rate to 2,752±0,624 (p<0.001), almost 14 times. In the study group, it was also a sevenfold increase in the synthesis of 224±8,244; p<0.001) compared with the control group (3,158±0,214). The content of anti-inflammatory factors, immunological protection of organism in patients with odontogenic osteomyelitis at admission was 0,462±0,064, which was a statistically significant increase (p>0,05) compared with those in the control group -0,416±0,058 Keywords: immunological status, acute odontogenic osteomyelitis of the jaws, interleukins Дата надходження рукопису 25.12.2015 Баранник Неонилла Гавриловна, доктор медицинских наук, профессор, заведующий кафедры хирургической и терапевтической стоматологии, ГЗ «Запорожская медицинская академия последипломного образования МЗ Украины», ГУ «Городская клиническая больница экстренной и скорой медицинской помощи», ул. Победы, 80, г. Запорожье, Украина, 69005 Варжапетян Сурен Диасович, ассистент, кандидат медицинских наук, кафедра хирургической и терапевтической стоматологии, ГЗ «Запорожская медицинская академия последипломного образования МЗ Украины», ГУ «Городская клиническая больница экстренной и скорой медицинской помощи»,

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