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The study of the restructuring of the body of a pregnant woman with relation to the theory of functional systems is necessary for a complete understanding of the formation of adaptive processes. Of particular interest is pregnancy resulting from extracorporeal fertilization (IVF). Aim. to estimate the adaptive capacity of women with physiological pregnancy and IVF. Materials and methods. The object of the study: healthy women before pregnancy and in the I trimester (I group), patients with tubal-peritoneal infertility at the planning stage and after an effective IVF (II group), women with an unsuccessful IVF (III group). We conducted a study of the functional state of the cardiovascular system of pregnant women with the calculation of adaptive potential (AP) by R. M. Bayevsky. We assessed the regulation of the vegetative nervous system — Kerdo index (KI). We determined the state of regulatory systems with the stress index (L.H. Garkavi et al.). Results. In patients with physiological pregnancy, we noted the effect on the cardiovascular system of the autonomic nervous system and the tension of adaptive reactions. In pregnant women with IVF we recorded the depletion of adaptive activity of the sympathetic autonomic nervous system. This led to a significant strain or failure of adaptation with the predominant influence of the parasympathetic autonomic nervous system. Conclusion. Significant differences in the studied parameters in women with ineffective IVF program at the stage of pregnancy planning may have important prognostic value for determining the tactics of management of patients.

The article presents the observation and description of a clinical case of opisthorchiasis invasion with the development of obturation cholestasis.

The purpose of the study is to analyze the dynamics of the development of the HIV epidemic process in the Tyumen region in 1993–2018 (without autonomous okrugs).Materials and methods. The work used epidemiological, descriptive-evaluative, analytical and statistical research methods, with the calculation of intensive (incidence, incidence) and extensive indicators (structure of incidence, incidence), determining the trend of the epidemic process.Results and conclusions. As of the end of 2018, more than 1,2% of the population is infected with HIV in the Tyumen region. The average long-term growth rate is +259,9% (expressed). Over the 26 years of HIV registration, men have been predominantly infected, the route of infection is parenteral (narcotic). Since 2002, the proportion of sexual transmission of HIV has doubled, sexual heterosexual transmission has become the leading one at the present stage of the development of the epidemic process (59,8%). A «portrait» of a modern HIV-infected person in the region can be considered a predominantly unemployed man or woman (taking into account the trend) aged 40–49 years and older, with a secondary specialized education, subject to deviant behavior (including when using drugs). At the present stage, there is an obvious redistribution of the structure of the identified HIV-infected people towards the predominance of older age groups and pensioners with an increase in HIV +52,8%. The decrease in the growth rate and the incidence rate of HIV over the past 3 years is a positive trend amid the generalized nature of the spread of HIV.

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