1,1-Diphenyl,2-picrylhydrazyl free radical scavenging, bactericidal, fungicidal and leishmanicidal properties of Teucrium stocksianum

Abstract

In the present study, we evaluated the pharmacological and toxicological effects of Teucrium stocksianum. The crude extract of T. stocksianum (Ts.Cr) and its subsequent organic fractions: n-hexane (Ts.Hex), chloroform (Ts.CHCl3) and ethyl acetate (Ts.EtAc) exhibited 1,1-diphenyl,2-picrylhydrazyl free radical scavenging activity with different potencies. Ts.EtAc was found to be most potent. Ts.Cr, Ts.Hex, Ts.CHCl3 and Ts.EtAc showed significant bactericidal activity against Escherichia coli, Staphylococcus aureus, Salmonella typhi, Shigella flexneri and Bacillus subtilis at their extent. Ts.Cr, Ts.Hex, Ts.CHCl3 and Ts.EtAc displayed fungicidal action against Aspergillus niger, Aspergillus flavus, Aspergillus fumigatus and Fusarium solani at various minimum inhibitory concentrations. Ts.Cr and Ts.EtAc exhibited marked inhibition of Leishmania tropica growth, observed after 48 and 96 hrs of treatment. These data indicate that the T. stocksianum methanolic extract and its resultant fractions possess antioxidant, antibacterial, antifungal and antileishmanial activities. Thus, the present research unearths the scientific base for T. stocksianum medicinal application as antioxidant and antimicrobial agents.

Chemical profiling, antimicrobial and insecticidal evaluations of Polygonum hydropiper L

“…These test tubes were inoculated with the fungal strains and were incubated at 27 °C for 7 days. Finally, test tubes were checked for inhibition of fungal growth [27]. …”

“…The tubes were inoculated by adding one loopful of already prepared fungal suspensions and were incubated at 27 °C. After 7–10 days, tubes were observed for fungal growth and MFCs were considered the lowest concentration which inhibited fungal growth [27]. …”

Phenolic, flavonoid contents, anticholinesterase and antioxidant evaluation of Iris germanica var; florentina

“…The oxygen consumption leads to the production of a chain of reactive oxygen species (ROS), which play an important role in energy production, regulation of cell growth, intercellular signalling and phagocytosis (Verma et al 2009). However, ROS may also be very injurious as they can readily attack biomolecules such as DNA, lipids, proteins, leading to genotoxicity, cancer, arthritis, arteriosclerosis, inflammation, diabetes and neurological disorders such as AD (Shah et al 2013). Plants and their products, rich in antioxidant compounds, are known to retard progression of AD and neuronal degeneration ).…”

Neuroprotective and Anti-Aging Potentials of Essential Oils from Aromatic and Medicinal Plants

“…These free radicals readily attack fatty acids, DNA, proteins, other essential molecules and are implicated in a variety of disorders including AD, cancer, aging, inflammation, Parkinson’s disease, diabetes, atherosclerosis and liver disease (Ayaz et al, 2014; Ahmad et al, 2015; Kamal et al, 2015; Sadiq et al, 2015; Shah et al, 2015). Free radicals which are produced during oxidation process are neutralized to non-radical forms by enzymes including CAT and hydroperoxidase.…”