3‐Amino‐3‐desoxyverbindungen von Uzarigenin, Oleandrigenin, Gitoxigenin und Digoxigenin. Partialsynthetische Versuche in der Reihe der Herzgifte, 6. Mitt.

Abstract

parameters arc listed in Tables 2a and 2b. Observed and calculated structure €actors may be obtaincd in tabular form €rom one of the authors (G. R.).All calculations were performed at our local computing center on an II3f/370-155 computer using our own program system. We thank Prof H . Batzer and Dr ,J. Sinnreich for suggesting the problem and supplying the crystals, Prof R. Huber and Dr H . Fehlhantmer for helpful discussions and hints rcgartling the Faltmolckiil mcthocl, and H . R.

Synthese von 4‐[3β, 14‐Dihydroxy‐5β, 14β‐androstan‐17β‐yl]‐3‐pyrrolin‐2‐on (Hothesimogenin). Partialsynthetische Versuche in der Reihe der Herzgifte, 11. Mitteilung

“…Als Ausgangsmaterialien werden dabei leicht isolierbare oder leicht erhaltliche Genine [2], Glykoside oder Pregnen-Derivate [3] [4] verwendet.…”

Design and synthesis of new azetidine‐steroid derivative with inotropic activity in a heart failure model

“…[9] In addition, an amino-steroid analog with inotropic activity was prepared from 3β,14-dihydroxy-5β-card-20 (22)enolide. [10,11] Other study showed the preparation of 17β-(3'-thiophenyl)-5β-androstane-3β,14β-diol 3-D-glucopyranoside via reaction of 5βandrostane-tetra-O-acetyl deri-vative with methylene chloride; this steroid derivative showed an inotropic activity in vitro. [12] In addition, the strophanthidin (3β,5,14-trihydroxy-19-oxo-5β,20(22)-carde-nolide) was synthetized from strophanthidol and chromic trioxide [13] which exerts a positive inotropic activity on cardiac purkinje fibers.…”