3-Amino-5-hydroxybenzoic Acid in Antibiotic Biosynthesis. XII. Origin of the Oxygen Functionality of the Ansamycin Antibiotic Actamycin.

Type I polyketide biosynthesis in bacteria (Part B) (1995 to mid-2000)

“…The related naphthomycins H 292 and A 293 contain chlor- 128 The fermentation broth also yielded two new metabolites 296 and 297 in which the thiol group of N-acetylcysteamine has added to C-30, to give compounds analogous to the natural thioansamycins naphthomycin F and G. The authors suggest that all these thionaphthomycins are obtained through a non-enzymatic addition-elimination reaction on the corresponding chlorometabolites (Scheme 22).…”

The biosynthesis of plant alkaloids and nitrogenous microbial metabolites (1997 to 1998)

“…Clearly, the polyketide enzymes early in biosynthesis are more tolerant towards an unnatural primer than at least one later in the pathway. 105 It has been shown 107 This organism produces thio-substituted derivatives 117. Enhanced production of thio-derivative could be stimulated by the addition of more thiol or different thio-compounds.…”