368 Anti-inflammatory effect of Citrus grandis Osbeck (dangyuja) leaves in LPS-stimulated raw 2764.7 cells

Yang, Eun Jin; Kang, Gyeong-Jin; Lee, Hye-Ja; Park, Sun-Soon; Yoon, Weon‐Jong; Kang, Hee‐Kyoung; Kim, So-Mi; Yoo, Eun-Sook

doi:10.1016/j.cyto.2008.07.453

Cited by 4 publications

(1 citation statement)

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“…The concentration of phytochemicals depends on many factors, such as the cultivar type, growing conditions, and country of origin. Our group has mainly focused on identifying anticancer and antioxidant activities and characterizing citrus phytochemical profiles (Lim et al, 2006;Kim et al, 2008;Yang et al, 2008). Recent investigations from our laboratory provided evidence for the health-promoting properties of citrus in cell culture studies, such as antioxidant activity and prevention of cancer (Lim et al, 2009;Kim et al, 2010;Cho et al, 2009;Moon et al, 2009).…”

Section: Methodsmentioning

confidence: 99%

Chemical Composition and Antiproliferative Activity of Supercritical CO2 Extracts from Citrus Fruits

Gyawali

Moon

Jeon

et al. 2012

FSTR

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Supercritical CO 2 extract from fruits of Citrus hassaku Hort ex Tanaka, Citrus iyo Hort. ex Tanaka, and Citrus grandis Osbeck, locally known as phalsak, yeagam, and dangyuja, respectively, in Korea, were analyzed by gas chromatography-mass spectrometry (GC-MS). In total, 70, 79, and 76 compounds were identified in fruits of phalsak, yeagam, and dangyuja respectively. (Z)-9-Octadecenoic acid was the major compound in phalsak, whereas limonene prevailed among the others. α-Terpineol, (E,E)-2,4-decadienal, hexadecanoic acid, pentacosane, stigmasterol, and γ-sitosterol were prominent in all species. Antiproliferative activity of the fruit extract was revealed through the colorimetric MTT (tetrazolium) assay against human glioblastoma U373MG, SNU-16 gastric cancer cells, HeLa cervix adenocarcinoma cells and AGS gastric adenocarcinoma cells. Although all tested fruit extracts exhibited antiproliferative effects toward cancer cells, different cell lines varied in their sensitivity to the same plant fruit extract.

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