3D Bioprinting: The Emergence of Programmable Biodesign

Abstract

Until recently, bioprinting was largely limited to highly interdisciplinary research teams, as the process requires significant input from specialists in the fields of materials science, engineering, and cell biology. With the advent of commercially available high‐performance bioprinters, the field has become accessible to a wider range of research groups, who can now buy the hardware off the shelf instead of having to build it from scratch. As a result, bioprinting has rapidly expanded to address a wide array of research foci, which include organotypic in vitro models, complex engineered tissues, and even bioprinted microbial systems. Moreover, in the early days, the range of suitable bioinks was limited. Now, there is a plethora of viable options to suit many cell phenotypes. This rapidly evolving dynamic environment creates endless opportunities for scientists to design and construct highly complex biological systems. However, this scientific diversity presents its own set of challenges, such as defining standardized protocols for characterizing bioprinted structures, which is essential for eventual organ replacement. In this progress report, the current state‐of‐the‐art in the field of bioprinting is discussed, with a special emphasis on recent hardware developments, bioprinting for regenerative medicine, and late‐breaking nontraditional topics.

The Photoinitiator Lithium Phenyl (2,4,6-Trimethylbenzoyl) Phosphinate with Exposure to 405 nm Light Is Cytotoxic to Mammalian Cells but Not Mutagenic in Bacterial Reverse Mutation Assays

“…Thus, extrusion bioprinting of a photopolymer containing cells is one popular method of creating tissue engineering constructs [ 4 ]. Despite the promise, photopolymer-based 3D bioprinting has not developed enough to find commercial success beyond in vitro models due, in part, to the complexity of the tissues and the large number of uncharacterized variables [ 5 ].…”

Advances in 3D bioprinting technology for cardiac tissue engineering and regeneration

“…There have been reports on the use of innovative bioinks and strategies such as using the emerging extrusion-based floating 3D printing to engineer eye-catching vascularized contractile myocardial parts or heart-shape constructions, which collectively marks an impressive milestone in the industry [ 162 , 163 ]. However, these artificial prints, compared to the hearts of large mammals or primates, are still naive in their generation of both the input and output mechanical strengths for long-term effects.…”

Microalgae as Future Superfoods: Fostering Adoption through Practice-Based Design Research

“…Artists, architects, and designers continuously update themselves with the latest technologies and innovations, and over the decades, they have challenged the previously accepted limits with their works. Among the several nature-based solutions that have been adopted so far (biocement formed thorough bacterial metabolic activity [34], 3D bioprinting [35], and mycelium-based products and structures [36], to name a few), designers are increasingly experimenting with algae and microalgae, for instance, with large-scale installations, new product designs, furniture, innovative bioplastic packaging, and energy and food systems. Accordingly, multifaceted research domains are opening up.…”