3D structured self-powered PVDF/PCL scaffolds for peripheral nerve regeneration

Cheng, Yuan; Xu, Yang; Qian, Yun; Chen, Xuan; Ouyang, Yuanming; Yuan, Weien

doi:10.1016/j.nanoen.2019.104411

Cited by 144 publications

(123 citation statements)

References 64 publications

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“…[ 4–6 ] In the active center of enzymes, the constant adjustment of molecular configuration produces intense electric fields around the active center, and these electric fields are considered to be an important factor for the high performance of an enzyme's catalytic capabilities. [ 7 ] In some types of cells or tissues, [ 8,9 ] such as the neural cells, [ 10 ] heart cells, [ 3,11 ] hearing organs, [ 12 ] or bone tissues, [ 6,13,14 ] the electrical signals are especially important for their proper function. Development of similar energy conversion devices using artificial materials would help increase our understanding of these advanced biological systems and promote the development of biomimetic and biomedical materials.…”

Section: Figurementioning

confidence: 99%

Enhanced Electricity Generation and Tunable Preservation in Porous Polymeric Materials via Coupled Piezoelectric and Dielectric Processes

Tong

Wang

et al. 2020

Advanced Materials

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Biological systems and artificial devices convert omnipresent low‐frequency and weak mechanical stimulation into electricity for important functions. However, in‐depth understanding of the energy conversion, boosting, and preservation processes of the coupled piezo‐dielectric phenomenon in polymeric artificial materials is still lacking. In this study, combined experimental and simulation methods are employed to rationalize the process of energy conversion and preservation via a coupled piezo‐dielectric phenomena in composite polymeric films. Both the intensity of the transmembrane electric voltages and the kinetic aspects of the energy generation and preservation process are elucidated. The study indicates that composite films consisting of a conductive filler fraction below the percolation threshold, effectively convert low‐frequency mechanical stimulation to preserved electrical energy. Interestingly, film structure engineered into porous film has the ability to break the intertwined high‐voltage and exhibits a low‐preservation‐period relationship; it can simultaneously provide high electric field intensity, high induction velocity, and a long preservation period. The model is not only supported by the experiments but is also consistent with the electricity generation and preservation features of other reported piezo‐dielectric films. The systematic understanding can facilitate and inspire new device designs to better address the energy, environmental, and biomedical challenges faced by modern societies.

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Section: Figurementioning

confidence: 99%

Enhanced Electricity Generation and Tunable Preservation in Porous Polymeric Materials via Coupled Piezoelectric and Dielectric Processes

Tong

Wang

et al. 2020

Advanced Materials

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“…The CD31 + stained cells of HSPS-SC and Autograft groups was more than that of HSPS, HSPS-VEGF and HSPS-SC groups. CD34 is a transmembrane protein marker in the vascular tissues [ 34 ], α-SMA is the important biomarker of parietal cells in newborn blood vessels [ 35 ]. According to the CD34/α-SMA co-immunofluorescence results ( Fig.…”

Section: Resultsmentioning

confidence: 99%

Comprehensive strategy of conduit guidance combined with VEGF producing Schwann cells accelerates peripheral nerve repair

Tong

Luo

et al. 2021

Bioactive Materials

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Peripheral nerve regeneration requires stepwise and well-organized establishment of microenvironment. Since local delivery of VEGF-A in peripheral nerve repair is expected to promote angiogenesis in the microenvironment and Schwann cells (SCs) play critical role in nerve repair, combination of VEGF and Schwann cells may lead to efficient peripheral nerve regeneration. VEGF-A overexpressing Schwann cells were established and loaded into the inner wall of hydroxyethyl cellulose/soy protein isolate/polyaniline sponge (HSPS) conduits. When HSPS is mechanically distorted, it still has high durability of strain strength, thus, can accommodate unexpected strain of nerve tissues in motion. A 10 mm nerve defect rat model was used to test the repair performance of the HSPS-SC (VEGF) conduits, meanwhile the HSPS, HSPS-SC, HSPS-VEGF conduits and autografts were worked as controls. The immunofluorescent co-staining of GFP/VEGF-A, Ki67 and MBP showed that the VEGF-A overexpressing Schwann cells could promote the proliferation, migration and differentiation of Schwann cells as the VEGF-A was secreted from the VEGF-A overexpressing Schwann cells. The nerve repair performance of the multifunctional and flexible conduits was examined though rat behavioristics, electrophysiology, nerve innervation to gastrocnemius muscle (GM), toluidine blue (TB) staining, transmission electron microscopy (TEM) and NF200/S100 double staining in the regenerated nerve. The results displayed that the effects on the repair of peripheral nerves in HSPS-SC (VEGF) group was the best among the conduits groups and closed to autografts. HSPS-SC (VEGF) group exhibited notably increased CD31 + endothelial cells and activation of VEGFR2/ERK signaling pathway in the regenerated nerve tissues, which probably contributed to the improved nerve regeneration. Altogether, the comprehensive strategy including VEGF overexpressing Schwann cells-mediated and HSPS conduit-guided peripheral nerve repair provides a new avenue for nerve tissue engineering.

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“…One possible hurdle for bench to bedside translation may be the inconvenience of an exogenous electrical supply. Piezoelectric polyvinylidene fluoride (PVDF) nano/micro material incorporation can provide scaffolds with self-powered electrical stimulation [ 223 , 224 ]. The use of magnetic coupling can also achieve wireless power transfer in biofluids or tissues [ 225 ].…”

Section: Conclusion and Future Prospectsmentioning

confidence: 99%

Anisotropic scaffolds for peripheral nerve and spinal cord regeneration

Xue

Shi

Kong

et al. 2021

Bioactive Materials

112

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The treatment of long-gap (>10 mm) peripheral nerve injury (PNI) and spinal cord injury (SCI) remains a continuous challenge due to limited native tissue regeneration capabilities. The current clinical strategy of using autografts for PNI suffers from a source shortage, while the pharmacological treatment for SCI presents dissatisfactory results. Tissue engineering, as an alternative, is a promising approach for regenerating peripheral nerves and spinal cords. Through providing a beneficial environment, a scaffold is the primary element in tissue engineering. In particular, scaffolds with anisotropic structures resembling the native extracellular matrix (ECM) can effectively guide neural outgrowth and reconnection. In this review, the anatomy of peripheral nerves and spinal cords, as well as current clinical treatments for PNI and SCI, is first summarized. An overview of the critical components in peripheral nerve and spinal cord tissue engineering and the current status of regeneration approaches are also discussed. Recent advances in the fabrication of anisotropic surface patterns, aligned fibrous substrates, and 3D hydrogel scaffolds, as well as their in vitro and in vivo effects are highlighted. Finally, we summarize potential mechanisms underlying the anisotropic architectures in orienting axonal and glial cell growth, along with their challenges and prospects.

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3D structured self-powered PVDF/PCL scaffolds for peripheral nerve regeneration

Cited by 144 publications

References 64 publications

Enhanced Electricity Generation and Tunable Preservation in Porous Polymeric Materials via Coupled Piezoelectric and Dielectric Processes

Enhanced Electricity Generation and Tunable Preservation in Porous Polymeric Materials via Coupled Piezoelectric and Dielectric Processes

Comprehensive strategy of conduit guidance combined with VEGF producing Schwann cells accelerates peripheral nerve repair

Anisotropic scaffolds for peripheral nerve and spinal cord regeneration

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