A 7 S Gammaglobulin Completely Neutralizing the Rheumatoid Factor Macroglobulin

Svartz, Nanna; Hedman, S.; Söderberg, Olof

doi:10.1111/j.0954-6820.1969.tb07292.x

Cited by 2 publications

(2 citation statements)

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“…As was reported in this journal (14), a 7 S gamma globulin, yG or IgG, was isolated from anti-Rheumatoid factor serum (anti-RF serum) produced in rabbits. This IgG showed the capacity in non-aggregated state of completely neutralizing the Rheumatoid factor.…”

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confidence: 85%

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Two Methods for Producing in Animals a Macroglobulin Similar to the Rheumatoid Factor

Svartz¹,

Hedman²,

Söderberg³

1969

Journal of Internal Medicine

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Two methods for provoking a haemagglutinating macroglobulin identical or similar to the Rheumatoid factor (RF) are described. The macroglobulins were obtained (a) by injections of Diplostreptococcus agalactiae into animals, mainly white rats; ( b ) by injecting into rats the antibody to RF (anti-RF) or the active fraction of this antibody. The anti-RF was produced by immunizing rabbits against RF. Both (a) and ( b ) have given rise to haemagglutinating macroglobulins showing high titres (up to 1 : 1024) in the sheep cell test. The titre is much more stable when using method (a). Using method (b) the results show sudden variations with sometimes total disappearence of the haemagglutinating macroglobulin.The anti-RF serum produced neutralizes the RF completely in precipitation tests. The active principle of anti-RF is a fraction showing a sedimentation constant of about 7 S, i.e. exactly the same as that of the common yG. Comparing the 7 S, which has the property of neutralizing RF completely in unheated state, and the common yG (IgG) by immunoelectrophoresis, the first does

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confidence: 85%

“…The next step consisted of trials in isolating the fraction of the anti-RF serum which gives rise to neutralization of R F (see the aforementioned article (14) in Acta med. scand.).…”

Section: Table I Example Of the Development Of A Haemagglutinating Mmentioning

confidence: 99%