A brief report of plexiform neurofibroma

Khajavi, Mehdi; Khoshsirat, Shahrokh; Ahangarnazari, Lida; Majdinasab, Nastaran

doi:10.1016/j.currproblcancer.2018.01.007

Cited by 15 publications

(18 citation statements)

References 12 publications

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“…Tenderness is often not accompanied in the early stage. With the growth of the tumor, pain and nerve compression can occur, causing corresponding symptoms and signs [10,11]. PN of brachial plexus and radial nerve has been reported in the relevant literature [12].…”

Section: Discussionmentioning

confidence: 99%

“…However, some studies have pointed out that the recurrence of isolated PN after surgical resection is rare.4 PN is a benign lesion with invasive growth, after 10-20 years of incubation, it can develop into malignant peripheral nerve sheath tumors (MPNST), with a risk of malignant transformation rate of approximately 2% ~ 5% [18,21]. It has even been reported that the risk of malignant transformation of PN is increased to 10% [10,24]. When the patient increases rapidly in a short time, the pain intensifies, and there is cystic degeneration and necrosis in the tumor, which indicates malignant transformation, poor prognosis, and high mortality [20].…”

Section: Imaging Findings Of Pnmentioning

confidence: 99%

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Rare recurrent solitary plexiform neurofibroma of the dorsum of the finger: A case report

Ou¹,

Li²,

Qu³

et al. 2022

J Clin Images Med Case Rep

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Background: Plexiform neurofibroma (PN) is a subtype of neurofibroma that is rather uncommon in the clinic. Plexiform neurofibroma is usually associated with neurofibromatosis type I (NF1). Only very few patients have isolated PN, which means they have neither NF1 signs nor relevant family history. Solitary PN is extremely rare. There have been no instances of finger back PN or solitary PN all around the world, which could lead to misdiagnosis, missed diagnosis, and mistreatment. Case presentation: We present a rare case of a 50-year-old middleaged woman who experienced numerous postoperative recurrences of painful tumors on the dorsal side of her proximal middle finger on her right hand. Following surgery, the pathology diagnosis was PN. The pathology diagnosis after surgery was PN. After the operation, the wound healed in stage I, and the outcomes were satisfactory. Conclusion: In the dorsal finger nerve, solitary PN can occur. As a result, the differential diagnosis of NF1, PN, and isolated PN as hand masses is crucial for early diagnosis and rational treatment, especially for masses with pain associated with neuropathy should be considered as a possibility of this disease. The lesion may be invasive or multiple in character, Keep a close eye on cautious probing throughout the surgery. To reduce recurrence, to avoid further deterioration, and to alleviate patients’ agony and psychological strain, the lesion tissue must be entirely removed. Keywords: Plexiform neurofibroma; Solitary plexiform neurofibroma; Neurofibromas; Recurrence; Case report.

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Section: Discussionmentioning

confidence: 99%

Section: Imaging Findings Of Pnmentioning

confidence: 99%

Rare recurrent solitary plexiform neurofibroma of the dorsum of the finger: A case report

Ou¹,

Li²,

Qu³

et al. 2022

J Clin Images Med Case Rep

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“…1,5,[18][19][20][21] Plexiform neurofibroma is an unusual type of neurofibroma and a benign tumor of the peripheral nerve that possesses a high risk of malignant transformation. 7,13,16,18,19,[22][23][24][25] Plexiform neurofibromas are usually diagnosed in early childhood and found in approximately 30% of NF1 cases, most frequently in the craniomaxillofacial region. 7,13,26 Malignant transformation occurs in 2% to 16% of cases and is considered the leading cause of mortality.…”

Section: Discussionmentioning

confidence: 99%

“… 1 Clinical manifestations of this abnormality consist of multiple skin alterations such as CALMs and axillary freckling, and by tumoral growth along nerves, called “neurofibromas.” 1 , 5 , 18–21 Plexiform neurofibroma is an unusual type of neurofibroma and a benign tumor of the peripheral nerve that possesses a high risk of malignant transformation. 7 , 13 , 16 , 18 , 19 , 22–25 Plexiform neurofibromas are usually diagnosed in early childhood and found in approximately 30% of NF1 cases, most frequently in the craniomaxillofacial region. 7 , 13 , 26 Malignant transformation occurs in 2% to 16% of cases and is considered the leading cause of mortality.…”

Section: Discussionmentioning

confidence: 99%

“…However, neurofibroma usually has diffuse tissue infiltration, which barely allows complete total resection. 18,33,41,[42][43][44] Tumor resection with preservation means patients can still take care of the cosmetics in the affected skin, but the risk of recurrence is more significant than with the other procedure. This approach depends on how aggressive the resection is and how carefully the healthy tissue is preserved.…”

Section: Observationsmentioning

confidence: 99%

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The recurrent plexiform neurofibroma of the scalp in neurofibromatosis type 1: illustrative case

Permana¹,

Parenrengi²,

Suryaningtyas³

et al. 2021

Journal of Neurosurgery: Case Lessons

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BACKGROUNDPlexiform neurofibroma is a benign tumor of the peripheral nerves. It is an unusual variant of neurofibroma originating from all parts of the nerve. Plexiform neurofibroma is primarily pathognomonic and exhibits an unusual variant from neurofibromatosis type 1 (NF1). The possibility of malignancy and recurrence are the main reasons for long-term, close follow-up.OBSERVATIONSThe authors report a case of a 14-year-old girl with a recurrent plexiform neurofibroma derived from the peripheral nerves, which also presented with a typical sign of NF1 disease. The aim of the tumor resection is symptomatic relief.LESSONSAccomplishing a good outcome can be related to good perioperative planning and a precise operative procedure. The result of anatomical pathology determines the prognosis of the patient. Clinical examination and radiological studies are needed to evaluate the recurrence of complications after surgical procedures.

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Trametinib for orbital plexiform neurofibromas in young children with neurofibromatosis type 1

et al. 2021

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A brief report of plexiform neurofibroma

Cited by 15 publications

References 12 publications

Rare recurrent solitary plexiform neurofibroma of the dorsum of the finger: A case report

Rare recurrent solitary plexiform neurofibroma of the dorsum of the finger: A case report

The recurrent plexiform neurofibroma of the scalp in neurofibromatosis type 1: illustrative case

Trametinib for orbital plexiform neurofibromas in young children with neurofibromatosis type 1

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