A Burn Wound Healing Model in the Hairless Descendant of the Mexican Hairless Dog

Matrix Therapy with RGTA OTR4120 Improves Healing Time and Quality in Hairless Rats with Deep Second-Degree Burns

“…Other animal models used to study burns include the micropig 22 and the hairless dog. 23 We induced superficial partial-thickness burn injuries at the dorsal aspect of the neck, where the skin was thinnest. The epidermis is thicker in hairless rats than in Wistar rats, the hair canals contain lamellar cornified tissue instead of hair, and some of the hair follicles deep in the dermis exhibit cyst formation.…”

A Standardized Model of Partial Thickness Scald Burns in Mice

“…Experimental models of partial thickness burn injury have been established in a number of mammalian species, including large mammals, such as pigs [2,3] and dogs [4,5], and small mammals, including guinea pigs [7,8] and rats [17][18][19]. While pig models share close anatomical similarities with human skin, and scald injuries are reepithelialized within 14 -21 days [3], the large size and high cost of these animals make this model less desirable for initial wound healing studies.…”

“…Ferrara et al [4] investigated regional blood flow changes following partial thickness scald injury in mongrel dogs. Matsumura et al [5] model in hairless dogs which completely reepithelializes in 18 -30 days, depending on the depth of dermal injury, closely corresponding to the time course seen in human partial thickness burn wounds. Bucky et al [6] showed that partial thickness contact burn wounds in New Zealand white rabbits completely reepithelialized by 18 days following injury.…”

Connective tissue sheath of hair follicle is a major source of dermal type I procollagen in human scalp

“…In dogs, hairy skin is thicker and better for wound healing than hairless skin [1]. In dogs, hairy skin is thicker and better for wound healing than hairless skin [1].…”