A carbositall electrode modified with a SiO2-hemoglobin-gold film as a promising biosensing element

Abstract

Abstracts-The analytical prospects of a carbositall electrode modified with a film based on SiO 2 , hemoglo bin (Hb), and gold nanoparticles (CSE SiO 2 -Hb-Au), prepared by deposition with an electrically generated catalyst, are reported. Hemoglobin on the surface of CSE SiO 2 -Hb-Au is shown to possess electrocatalytic activity toward dissolved oxygen, giving a rationale for the development of a rapid voltammetric procedure of O 2 quantification with a detection limit of 0.1 mg/L. The inhibition activity of a number of nitrogen contain ing organic substances to the catalytic current CSE SiO 2 -Hb-Au is studied. A voltammetric procedure is proposed for determination of the anti flu drug rimantadine, 1 (1 adamantyl)ethylamine hydrochloride, with a detection limit of 0.4 mg/L. The procedure is applicable to the quantification of rimantadine in blood serum and saliva.