A Clinico- Hematological Study in Cases of Pancytopenia: Correlation of Automated Cell Counter Parameters in Various Etiologies

Yadav, Soma; Kushwaha, Rashmi; Aggrawal, Kamal; A.K, Tripathi; U.S, Singh; Kumar, Ashutosh

doi:10.14260/jemds/795

Cited by 5 publications

(7 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The increase is particularly seen in P. falciparum. [23] Megaloblastic anemia (18.6%) was the second common cause of pancytopenia which coincides with studies done by Niazi et al [7] (24.7%) and Soma et al [5] (21.7%). In various studies, the incidence varied from 3.6% to 74%.…”

Section: Causes Of Pancytopeniasupporting

confidence: 84%

“…The mean corpuscular volume (MCV) was increased in 65 cases, decreased in 53 cases and normal in 108 cases. Ishtiaq et al [13] and Soma et al [5] noted raised MCV in 37 cases and 13 cases respectively. The diagnosis of megaloblastic anemia should be considered when MCV is above 100fL.…”

Section: Discussionmentioning

confidence: 99%

“…A total of 226 cases were selected based on the criteria: Haemoglobin: <10gm/dl, total leucocyte count: <4000/cmm and platelet count: < one lakh/cmm. [4], [5], [6], [7], [8] Patients on chemotherapy or radiotherapy, diagnosed cases of pancytopenia and recently received blood transfusions were excluded from this study.…”

Section: Methodsmentioning

confidence: 99%

“…Sweta et al [14] India 2014 100 5-80 MA AA ML Tonape et al [4] India 2014 210 All MA AA ALL Dahake et al [9] India 2014 94 All MA AA AL Soma et al [5] India 2013 60 All AA MA AL Parmar et al [19] India 2013 100 1-95 MA ML AA Thakkar et al [11] India 2013 100 >12 MA ML HS Jain et al [10] India 2013 250 All HS IF MS Tareen et al [18] Pakistan 2012 180 All ML LK TB Gayathri et al [16] India 2011 104 2-80 MA AA SLL Hamid et al [12] Yemen 2008 75 3-85 ML HS MA Niazi et al [7] Pakistan 2004 89 1-30 BM Aplasia MA HS Khunger et al [8] India 2002 200 2-70 MA AA SLL Tilak et al [17] India…”

Section: Third Causementioning

confidence: 99%

“…The incidence of dengue was found to be 17.95% in Kamothe, Navi Mumbai. [5] Malaria and dengue fever are both endemic in India with active transmission being reported for many years. Thus, there is a possibility of co-existing malaria and dengue infection in the same patient.…”

Section: Annals Of Pathology and Laboratory Medicine Vol 5 Issue 2mentioning

confidence: 99%

See 4 more Smart Citations

Clinico-hematological analysis of pancytopenia in adults – A two year prospective study

Patel¹,

Tambekar

Dhar

2018

APALM

View full text Add to dashboard Cite

Clinico-hematological Analysis of Pancytopenia in Adults-A Two Year Prospective Study EDTA anticoagulated blood (2ml) was collected, processed through automated 5part differential cell analyzer and hematological parameters were obtained. Peripheral blood smear was stained with Field's and Leishman stain and examined for RBC, WBC and platelet morphology along with hemoparasites. Anemias were classified morphologically as normocytic normochromic, microcytic hypochromic, macrocytic & dimorphic anemia. Informed consent was taken before performing bone marrow aspiration in cases where it was required. Special tests: Rapid malarial antigen test, dengue card test, leptospirosis card test, tests for HIV, Hepatitis viruses, serum vitamin B12, serum iron studies, liver and renal function tests and tests for tuberculosis, USG abdomen, CT and MRI scans, PET scans, etc. were also performed.

show abstract

Section: Causes Of Pancytopeniasupporting

confidence: 84%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Third Causementioning

confidence: 99%

Section: Annals Of Pathology and Laboratory Medicine Vol 5 Issue 2mentioning

confidence: 99%

See 3 more Smart Citations

Clinico-hematological analysis of pancytopenia in adults – A two year prospective study

Patel¹,

Tambekar

Dhar

2018

APALM

View full text Add to dashboard Cite

show abstract

Pancytopenia - A Study of 58 Cases

Para¹,

Para²

2013

jemds

View full text Add to dashboard Cite

BACKGROUND: Pancytopenia means decrease in all three cell lines. It is the striking feature of of many illness ranging from megaloblastic anaemia to leukemias. The underlying pathology of pancytopenia will determine the management and prognosis. OBJECTIVE: To identify the various causes of Pancytopenia. MATERIALS AND METHODS: The present study was undertaken at A Private Lab. RESULTS: 58 cases were studied, 30males and 28 females with age ranging from 3 yrs to 90 yrs. Most of the cases presented with generalized weakness, followed by pallor, hepatosplenomegaly and bleeding manifestations. CONCLUSION: The present study was helpful in understanding the various causes of diseases process with bone marrow aspiration done in few of the pancytopenic patients along with support of biochemical investigations which were helpful in planning further investigations and management.

show abstract

Clinico-hematological evaluation in cases of pancytopenia at tertiary care centre: largest cross-sectional study

2021

View full text Add to dashboard Cite

Background: Pancytopenia is characterised by a reduction in all the three cellular elements of blood (erythrocytes, leukocytes and platelets) below the normal reference range leading to anaemia, leucopenia and thrombocytopenia. It is a feature of many serious conditions. The present study was conducted to assess aetiology, clinical profile and bone marrow morphology of conditions presenting with pancytopenia.Methods: A two years cross-sectional study from July 2017 to June 2019 was conducted in the Department of Pathology. Total of 300 pancytopenia patient were studied and their clinical features, peripheral smear finding and bone marrow morphology were studied by using marrow aspiration and biopsy.Results: Among 300 cases studied, maximum patients were in the age group 11-20 years (19.66%) with male (50.66%) predominance. Most of the patients presented with weakness (91.66%) and fever (56.66%) as chief complains. The commonest physical finding was pallor (94%) followed by splenomegaly (27.33%). Macrocytic anaemia (43.66%) was commonest peripheral finding. The commonest cause of pancytopenia was megaloblastic anaemia (32.66%) followed by dimorphic anaemia (21%), aplastic anaemia (16%) and acute leukaemia (13.33%).Conclusions: The present study concludes that detailed clinical history, primary haematological investigations along with bone marrow examinations is essential to determine the cause of pancytopenia.

show abstract

A Clinico- Hematological Study in Cases of Pancytopenia: Correlation of Automated Cell Counter Parameters in Various Etiologies

Cited by 5 publications

References 11 publications

Clinico-hematological analysis of pancytopenia in adults – A two year prospective study

Clinico-hematological analysis of pancytopenia in adults – A two year prospective study

Pancytopenia - A Study of 58 Cases

Clinico-hematological evaluation in cases of pancytopenia at tertiary care centre: largest cross-sectional study

Contact Info

Product

Resources

About