A Clinicopathologic Report of the Retinal Lesions Associated With Didanosine

Didanosine-induced retinopathy in adults can be reversible

“…Partial loss of the choriocapillaris and neurosensory retina were also noted. 3 Transmission electron microscopy demonstrated numerous membranous lamellar inclusions and cytoplasmic bodies in the RPE cells. These changes were seen in the retinal periphery, with the macula being spared both clinically and histologically.…”

“…Ocular complications resulting from DDI can include retinopathy [3][4][5] and optic neuritis. 4,6 DDIR was first reported in children, 4 and later in adults.…”

“…7 Retinal lesions, studied more extensively in children, appear as areas of RPE mottling and atrophy in the midperiphery, which later become circumscribed by RPE hypertrophy. 3,5 These lesions progress while the patient is on treatment but may stabilize after treatment is withdrawn. [3][4][5] Histopathological analysis in a child demonstrated multiple areas of RPE loss surrounded by areas of hypertrophy and hyperpigmentation of the RPE.…”

“…3,5 These lesions progress while the patient is on treatment but may stabilize after treatment is withdrawn. [3][4][5] Histopathological analysis in a child demonstrated multiple areas of RPE loss surrounded by areas of hypertrophy and hyperpigmentation of the RPE. Partial loss of the choriocapillaris and neurosensory retina were also noted.…”

“…3 We present a case of a HIV patient with a clinical and electrophysiological diagnosis of DDI retinopathy (DDIR), whose electrophysiological abnormalities improved following DDI withdrawal.…”