A coding SNP of LHX4 gene is associated with body weight and body length in bovine

Abstract

Heterozygous mutations in LHX4 are associated with combined pituitary hormone deficiency. In this study, the polymorphism of LHX4-HaeIII locus was revealed in 822 individuals from four Chinese cattle breeds. The PCR-RFLP analysis showed that there were three genotypes: GG, GA, AA. The frequencies of genotype GG ranged from 0.6620 to 0.9789 in analyzed populations. The genotypic frequencies of LHX4 locus in the four populations all agreed with Hardy-Weinberg equilibrium (P > 0.05). Distributions of genotypic frequencies of different breeds (QC, NY, JX, CH) at this locus were found to be significantly different based on a chi(2) test (P < 0.001). The genetic diversity analysis revealed the JX cattle possessed intermediate genetic diversity, and the other three Chinese cattle breeds belonged to poor genetic diversity. Correlation analysis with growth traits in the NY breed indicated that: the animals with genotype GA had greater body weight than those with genotype GG (P < 0.05); the animals with GA genotype owned significantly longer body length than the ones with GG genotype (P < 0.05) at 18 and 24 months.

Short communication: Polymorphism of the <i>GnRHR</i> gene and its association with litter size in Boer goats

“…Although those mutations do not change the amino acid sequences, it probably affects the density of GnRHR on the gonadotropes by influencing the expression of the GnRHR gene and the stability of the GnRHR transcription, and could then result in a decrease or increase of gonadotrophins concentrations (Schubert et al, 2000;Leanos-Miranda et al, 2002). It has been observed that the synonymous SNP can affect in vivo protein folding and consequently its function, as well as gene expression and phenotype (Kimchi-Sarfaty et al, 2007;Ren et al, 2010;Tang et al, 2011). In summary, our results identified two new polymorphisms (G891T and G757A) in the goat GnRHR gene, and showed an association with allele T at 891 locus between the GnRHR gene and the high litter size in the first and third parity in Boer goats.…”

The novel 22 bp insertion mutation in a promoter region of the &lt;i&gt;PITX2&lt;/i&gt; gene is associated with litter size and growth traits in goats

“…Yan et al (2018) found that a 12 bp deletion within the goat LHX4 gene significantly affected litter size. Variants of LHX4 gene were also associated with growth traits (Ren et al, 2010). Therefore, all of the evidence indicates that different alleles have a similar potential advantage in marker-assisted selection (MAS).…”

Health and production traits in bovine are associated with single nucleotide polymorphisms in the NOD2 gene

“…The traits were compared between genotypes. The relationship between genotypes of the NOD2 gene and bovine mastitis and milk quality were analyzed using one-way analysis (Wang et al, 2010;Ren et al, 2009) with the following model: Yijkl = observed value; µ = overall mean for each trait; BFi = fixed effect of i th breed and farm; Mj = fixed effect of j th month of slaughtering; G = fixed effect of k th single SNP marker genotype; Eijkl = random error.…”