A Comparative Clinical Study of Unani Formulation (Maghz Tukhm-e-Jamun wa Tukhm-e-Hayat) and Metformin in the Management of Ziabetus Shakari (Type 2 Diabetes Mellitus)

Abstract

Diabetes mellitus is a metabolic disorder of multiple etiology, characterized by chronic hyperglycemia with disturbances of carbohydrate, fat, and protein metabolism resulting from defects in insulin secretion, insulin action, or both (1). The cost of diabetes care is high and escalating worldwide. The number of people with diabetes is increasing in every country. Half of the people with diabetes are not aware that they have it, and four out of five people with diabetes live in low-and middleincome countries. Half of the people who die from diabetes are aged less than 60 years (2,3).According to the World Health Organization, the prevalence of diabetes in adults has increased worldwide, and the number is expected to rise from 135 million in 1995 to 300 million by the year 2025 (4). According to Rao et al., 32 million patients had diabetes in India in 2005, which might increase to 80 million by the year 2030 (5). According to Madras Diabetes Research Foundation, Chennai, this disorder is the most prevalent in South Asia, especially in India, which has earned the unwelcome title of the "Diabetes Capital" of the world with 41 million individuals with diabetes (6). The number of people living with diabetes in India currently is around 69.2 million (7).This disorder is frequently associated with long-term complications such as atherosclerosis, ischemic heart disease, chronic renal failure, and ketoacidosis. It is a leading cause of morbidity and mortality owing to its complications. Due ABSTRACT Type 2 diabetes mellitus is a major health concern in the 21st century, which is largely preventable but remains responsible for millions of deaths annually and many life-threatening complications. The present study was conducted to evaluate and compare the efficacy of Withania coagulans Dunal and Eugenia jambolana Lam with that of standard control metformin in managing type 2 diabetes mellitus.This was a randomized open study with standard control. A total of 60 diagnosed cases of type 2 diabetes mellitus were randomly allocated in the test (n = 30) and control groups (n = 30). Test drug, a combination of E. jambolana (6 g in powder form) and oral infusion of W. coagulans (10 pieces), and control drug metformin (500 mg) were administered to the participants twice daily for 90 days. The subjective parameters were assessed at every follow-up, blood sugar was recorded at a monthly interval, while hemoglobin A1c, RFT, and lipid profile were recorded at baseline and at the termination of the trial. The study outcome was analyzed using appropriate statistical tests. The test drug showed significant improvement at par to the control drug in subjective (polydipsia, polyphagia, fatigue, and weight loss) and objective (blood sugar, glycated hemoglobin, RFT, serum cholesterol, and serum triglyceride) parameters without any side effects or toxicity. The study inferred that the drug was safe and effective in managing type 2 diabetes mellitus.

Comparative evaluation of efficacy and safety of A Unani coded drug UNIM-221 and Metformin in cases of Diabetes mellitus type-II: A preliminary study

“…Diabetes mellitus (Ziabetes shakari) is a metabolic disorder of multiple diagnoses, specified by chronic hyperglycemia with disturbances of carbohydrate, fat, and protein metabolism as a result from defects in insulin secretion, insulin action, or both [1] . In 2000, India (31.7 million) superimposed the world with the highest number of people with diabetes mellitus followed by China (20.8 million) with the United States (17.7 million) in second and third place respectively.…”

Effect Of Withania Coagulans And Liraglutide On Serum Glp-1, Postprandial And Fasting Blood Glucose In Streptozotocin Induced Diabetic Rats

“…Effect of Withania Coagulans extract on reducing glucose levels were similar to the reesults produced by using biguanides and sulphonylureas. 13 Moreover different studies in animal model have also shown that aqueous extract of Withania Coagulans (aqWC) significantly improves pancreatic islets cells architecture. 14 However Anti-diabetic effect of aqueous extract of Withania Coagulans on incretin hormone has not…”