A Comparative Study of the Effectiveness of Preservatives in Twelve Antacid Suspensions

Vanhaecke, Erwin; Remon, Jean‐Paul; Pijck, J.; Aerts, Rudi; Herman, J.

doi:10.3109/03639048709068384

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1994

2012

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Cited by 4 publications

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“…In a recent survey [4] it was shown that eight out of twelve marketed antacid suspensions failed to meet the LISP requirements for preservative activity. In a recent survey [4] it was shown that eight out of twelve marketed antacid suspensions failed to meet the LISP requirements for preservative activity.…”

Section: Discussionmentioning

confidence: 99%

The preservation of some oral liquid preparations

Doorne

Leijen

1994

Pharm World Sci

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Chloroform should be considered as an obsolete preservative for pharmaceutical preparations, because of its toxicological implications and its physical instability. The effectiveness of possible alternatives for chloroform in three oral liquid pharmaceutical preparations was investigated, using a microbiological challenge test. Magnesium trisilicate mixture (British Pharmacopoeia) can be adequately preserved with methylparaben (2 g/l). Only insignificant amounts of methylparaben were absorbed by the solids present in the magnesium trisilicate mixture. Ferrous sulfate mixture (British Pharmacopoeia) can be preserved with a mixture of methylparaben (1.8 g/l) and propylparaben (0.2 g/l). Sorbic acid (1 g/l) is a suitable preservative for promethazine hydrochloride syrup.

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Section: Discussionmentioning

confidence: 99%