A comparative study of the antimitagenic effects of antioxidants on chemical mutagenesis in Drosophila melanogaster

Гончарова, Р. И.; Kuzhir, Tatyana D.

doi:10.1016/0027-5107(89)90170-x

Cited by 35 publications

(13 citation statements)

References 30 publications

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“…Diludine is absorbed in gastrointestinal tract and distributed comparatively evenly in organism. No residual quantities of the preparation are detected in organs and tissues in 72 h. It does not display embryotoxic, mutagenic effect and is not accumulated in animal organism (Goncharova & Kuzhir 1989). Therefore, it is widely used as antioxidant in food and for stabilization of edible oils (Kourimska et al.…”

Section: Discussionmentioning

confidence: 99%

Effects of diludine supplementation on growth performance, liver antioxidant enzyme activities and muscular trace elements of rainbow trout (Oncorhynchus mykiss) juveniles at a low water temperature

Hisar

Yanık

Kocaman

et al. 2011

Aquaculture Nutrition

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Diludine is used as an effective agent reducing mutagenic effects of environmental pollutants, increasing productivity and protecting reproductive system of parental individuals and quality of their offspring. A 10‐week study was conducted to evaluate potential effects of diludine on rainbow trout (Oncorhynchus mykiss) juveniles growth performance, feed utilization, survival rate, liver antioxidant enzyme activities (superoxide dismutase, SOD, http://www.chem.qmul.ac.uk/iubmb/enzyme/EC1/15/1/1.html; catalase, CAT, http://www.chem.qmul.ac.uk/iubmb/enzyme/EC1/11/1/16.html; glutathione peroxidase, GPx, http://www.chem.qmul.ac.uk/iubmb/enzyme/EC1/11/1/9.html; glutathione reductase, GR, http://www.chem.qmul.ac.uk/iubmb/enzyme/EC1/6/4/2.html; glucose‐6‐phosphate dehydrogenase, G6PD, http://www.chem.qmul.ac.uk/iubmb/enzyme/EC1/1/1/49.html and glutathione S‐transferase, GST, http://www.chem.qmul.ac.uk/iubmb/enzyme/EC1/5/1/18.html), the levels of malondialdehyde (MDA) as a lipid peroxidation marker and muscular trace elements at a low water temperature (9 °C). Diludine was added at 0.2, 0.5 and 1 g kg−1 to a fish meal–based control diet, and each diet was fed to triplicate groups of rainbow trout juveniles. After 10 weeks, there were no differences in survival rate between fish fed experimental diets (P > 0.05). It was observed that a significant improvability existed for both growth and feed utilization in fish fed diets supplemented with diludine (P < 0.05). Antioxidant enzymes showed significantly increased activity in liver tissues (P < 0.05) and then a decrease to initial activity levels during the experimental time. (GPx activity was not determined in the juvenile livers.) SOD and GST activities in liver of fish fed the diets with diludine tended to be higher and GR activity tended to be lower than that in fish fed the basal diet. However, in general, it was determined that different concentration of diludine did not affect the studied antioxidant enzyme activities except G6PD in the liver of juveniles fed the diet with 1 g kg−1 diludine. On the other hand, the significant reduction was found in MDA levels in the fish fed the diets with diludine compared with basal diet on the 14th and 28th days of experiment. It was also observed that Cu, Fe, Mg, Zn and Se levels were significantly higher in the juveniles fed the diet with 1 g kg−1 diludine than those fed the basal diet. In conclusion, the results of this trial indicate that 1 g kg−1 dietary supplementation with diludine seems to be most positive for rainbow trout production in cold‐water adaptation.

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Section: Discussionmentioning

confidence: 99%

Effects of diludine supplementation on growth performance, liver antioxidant enzyme activities and muscular trace elements of rainbow trout (Oncorhynchus mykiss) juveniles at a low water temperature

Hisar

Yanık

Kocaman

et al. 2011

Aquaculture Nutrition

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“…While all metabolites or derived forms of this pesticide (endosulfan) usually and almost quickly get excreted out of the body in the form of water soluble products (chiefly endosulfan alcohol), its lipophilic sulphated form (endosulfan sulphate), of genotoxic nature, gets stored in the body-fat as lipid conjugates (Deema et al 1966, Maier-Bode 1968, Rao 1989. The antioxidant vitamin C might be producing antigenotoxic effect by blocking the oxidation (Goncharova and Kuzhir 1989) of endosulfan into endosulfan sulphate. Vitamin C might also be reacting with the electrophilic metabolites of the pesticide before scavenging them out.…”

Section: Discussionmentioning

confidence: 99%

“…Vitamin C might also be reacting with the electrophilic metabolites of the pesticide before scavenging them out. Its competition with pesticide metabolites for occupying nucleophilic sites on DNA can also prevent DNA-mutagen adduct formation (Goncharova and Kuzhir 1989).…”

Section: Discussionmentioning

confidence: 99%

Dose-Dependent Minimisation of Cytogenetic Toxicity of Endosulfan(an Organochlorine Pesticide) by Vitamin C.

Khan

Sinha

1992

CYTOLOGIA

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“…It is known, however, that AA has marked nucleophilic properties and it might intercept reactive electrophilic metabolites produced by Pb, thereby preventing their attack on nucleophilic sites on DNA and hence blocking adduct formation (Liehr et al , 1989). Otherwise, AA is an anti‐oxidant that might inhibit the oxidative metabolism of Pb and thus could prevent the production of mutagenic electrophilic metabolites (Goncharova & Kuzhir, 1989). Also as part of a redox buffer system, AA can scavenge harmful free radical metabolites or reactive oxygen species (Sato et al , 1990).…”

Section: Discussionmentioning

confidence: 99%

The protective influence of ascorbic acid against the genotoxicity of waterborne lead exposure in Nile tilapia Oreochromis niloticus (L.)

Jiraungkoorskul

Sahaphong

Kangwanrangsan

et al. 2008

Journal of Fish Biology

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The present study investigated the effects of lead (Pb) and ascorbic acid (AA) on Nile tilapia Oreochromis niloticus using the micronucleus (MN) and nuclear abnormality (NA) tests for periods of 7, 14 and 21 days. The MN frequencies in the erythrocytes, gill, liver and fin cells were analysed comparatively to evaluate the sensitivity and suitability of these different cell types. The NA shapes in erythrocytes were scored into blebbed nuclei (BL), lobed nuclei (LB), notched nuclei (NT) and binuclei (BN). It was observed that fish showed significant sensitivity to the different treatments. In general, the highest value of both MN and NA cells were significantly increased in the Pb-treated group followed by the combination of the Pb and AA-treated group. On the other hand, the MN and NA frequencies in erythrocytes were the most sensitive to the treatment and could provide more valuable information than those in gill, liver and fin cells. The frequencies of each NA shape in erythrocytes of all treatments were observed in the following ranked order NT > LB > BN > BL. The results demonstrated the efficacy of AA in reducing genotoxicity in fish induced by Pb. They showed the sensitivity and suitability of MN and NA frequencies in erythrocytes as pollution biomarkers.

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A comparative study of the antimitagenic effects of antioxidants on chemical mutagenesis in Drosophila melanogaster

Cited by 35 publications

References 30 publications

Effects of diludine supplementation on growth performance, liver antioxidant enzyme activities and muscular trace elements of rainbow trout (Oncorhynchus mykiss) juveniles at a low water temperature

Effects of diludine supplementation on growth performance, liver antioxidant enzyme activities and muscular trace elements of rainbow trout (Oncorhynchus mykiss) juveniles at a low water temperature

Dose-Dependent Minimisation of Cytogenetic Toxicity of Endosulfan(an Organochlorine Pesticide) by Vitamin C.

The protective influence of ascorbic acid against the genotoxicity of waterborne lead exposure in Nile tilapia Oreochromis niloticus (L.)

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