A Familial Study of the Inheritance of HLA-B27-Positive Acute Anterior Uveitis

Derhaag, P. J. F. M.; Linssen, A.; Broekema, N; Waal, L. P. de; Feltkamp, T. E. W.

doi:10.1016/0002-9394(88)90051-7

Cited by 53 publications

(18 citation statements)

References 11 publications

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“…This chance is ten times higher than for someone being B27 negative. If, however, a B27 positive individual has a relative also being B27 positive who also had AAU, the chance to develop the disease is even 13% [12]. This finding points to the existence of other genetic factors [13,14].…”

Section: Pathogenic Significance Of Hla and Disease Associationsmentioning

confidence: 92%

HLA and uveitis

Feltkamp

1990

Int Ophthalmol

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The association between HLA-A29 and birdshot chorioretinopathy is the strongest of all associations between HLA and disease. Determination of HLA-A29 is even of diagnostic significance. The association between HLA-B27 and acute anterior uveitis (AAU) is much weaker, but B27 positive AAU may be considered as a distinct clinical entity. B27 positive patients with AAU should be referred to a rheumatologist, because half of these patients have ankylosing spondylitis or Reiter's syndrome. The determination of HLA-Bw51 is of limited but significant diagnostic value for the diagnosis of Behçet's disease. The present article shows how HLA determinations can serve as diagnostic tests. It is explained how the sensitivity and specificity of such tests can be used to calculate the influence of positive or negative results on the probability of the diagnosis. The structure and function of HLA class I molecules is now known to a great extent. This may lead to a better understanding of the pathogenic role of HLA-A29, HLA-B27, HLA-Bw51 and other HLA molecules which are associated with uveitis.

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Section: Pathogenic Significance Of Hla and Disease Associationsmentioning

confidence: 92%

HLA and uveitis

Feltkamp

1990

Int Ophthalmol

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“…Furthermore, HLA-B27 AAU occurs in B27-positive members of the patients' families (approximately 10%) more frequently than in B27-positive healthy controls (1-2%). 5 Posterior segment involvement in HLA-B27-associated uveitis occurs somewhere between 4 and 17.4% in Caucasians. 2,6 Benitez del Castillo reported that the blood-aqueous barrier had been broken when HLA-B27-positive acute anterior uveitis was in active stage.…”

Section: Commentmentioning

confidence: 99%

Proliferative vitreoretinopathy developed in HLA-B27-associated uveitis

Kodama

Numaga

Kaburaki

et al. 2003

Eye

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“…To our knowledge, this is the first case reported with retinal haemorrhages as a side effect of trimethoprim. HJA-B27 genotype is present in approximately 50% of patients with acute anterior uveitis compared with 8% in the normal population (Brewerton 1973) and the disease has been reported in 1% of otherwise normal HLA-B27 individuals (Derhaag 1988). HLA-B27 genotype may have increased the patient's susceptibility to uveitis in reaction to the drugs.…”

mentioning

confidence: 99%

Bilateral anterior uveitis and retinal haemorrhages after administration of trimethoprim

Kristinsson

Hannesson

Sveinsson

et al. 1997

Acta Ophthalmologica Scandinavica

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ABSTRACT. In this case report we present a female patient with recurrent urinary infection treated with trimethoprim/sulfamethoxazole, trimethoprim alone and ciprofloxacin. She developed adverse systemic symptoms and bilateral anterior uveitis following administration of the former two drugs, and in addition retinal haemorrhages after the use of trimethoprim. Uveitis and retinal haemorrhages are rare side effects of trimethoprim/sulfamethoxazole. To our best knowledge they have not been described as a side effect of trimethoprim alone. and in November they had cleared completely.The patient had several exposures of TMP/SMX and trimethoprim alone resulting in uveitis, but not when treated with ciprofloxacin.

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A Familial Study of the Inheritance of HLA-B27-Positive Acute Anterior Uveitis

Cited by 53 publications

References 11 publications

HLA and uveitis

HLA and uveitis

Proliferative vitreoretinopathy developed in HLA-B27-associated uveitis

Bilateral anterior uveitis and retinal haemorrhages after administration of trimethoprim

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