A Family with Allo-Immune Neonatal Neutropenia: Group-Specific Pathogenicity of Maternal Antibodies

Verheugt, F.W.A.; Noord-Bokhorst, J.C. van; Borne, A. E. G. K. Von Dem; Engelfriet, C.P.

doi:10.1159/000460418

Cited by 10 publications

(12 citation statements)

References 8 publications

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“…41,42 The incidence is estimated at 1 in 500 live births. In this syndrome, neu trophils and neutrophil precursors of the fetus are destroyed by the transplacental passage of maternal IgG alloantibod ies formed against HLA or neutrophilspecific antigens (NA1 and NA2) present on fetal as well as on paternal neutrophils but not on maternal ones.…”

Section: Acquired Neutropeniasmentioning

confidence: 99%

Abnormalities in leukocyte morphology and number

Zini¹

2011

Blood and Bone Marrow Pathology

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Section: Acquired Neutropeniasmentioning

confidence: 99%

Abnormalities in leukocyte morphology and number

Zini¹

2011

Blood and Bone Marrow Pathology

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“…However, even in patients with a positive direct GIFT result, any serum granulocyte antibodies detected may be the result of alloimmunization. In this study, exclusion of any LIFTpositive sera has eliminated the possibility that HLA anti bodies have been detected in the GCLT or GIFT but it remains possible that alloimmunisation to granulocyte an tigens by pregnancy (reported at 3% of live births by Ver fleugt et al [27]) and by transfusion may account for some of the positive reactions found in the sera of patients with presumed PAN or SAN. Consequently, the data for PAN and SAN patients in whom a previous history of preg nancies or transfusion was clearly absent was analyzed.…”

Section: Relationship Between Direct Gift and Indirect Gclt And Gift mentioning

confidence: 89%

Prospective Evaluation of the Chemiluminescence Test for the Detection of Granulocyte Antibodies: Comparison with the Granulocyte Immunofluorescence Test

Lucas¹

1994

Vox Sanguinis

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A series of 213 neutropenic patients were tested for the presence of granulocyte antibodies using the granulocyte chemiluminescence test (GCLT) and the granulocyte immunofluorescence test (GIFT). Sera containing lymphocyte (HLA) antibodies were excluded from the study. A direct GIFT was performed on granulocytes from 56 patients. Samples were obtained from patients with a range of clinical conditions including primary adult autoimmune neutropenia, autoimmune neutropenia of infancy, autoimmune neutropenia secondary to Felty’s syndrome, rheumatoid arthritis, idiopathic thrombocytopenic purpura, systemic lupus erythematosus, proliferative disorders, bone marrow transplantation and patients with documented febrile or pulmonary transfusion reactions. Overall, granulocyte antibodies were detected in 52.1% of patient sera. Results for the GCLT and GIFT (IgG) were strongly correlated (p<0.001) for both primary and secondary immune neutropenias. The results confirm the applicability of the GCLT in the granulocyte serology laboratory.

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“…The incidence of ANN is about 1 in 2,000 neonates. Alloimmunization during pregnancy occurs in about 1-3% of pregnant women, but alloantibodies with specificity for a known alloantigen are only observed in 0.1-0.4% of pregnancies [7][8][9]. ANN may occur in the first-born child [7,10].…”

Section: Clinical Conditionsmentioning

confidence: 99%

Granulocyte Antibody-Mediated Neutropenias and Transfusion Reactions

Bux¹

1999

Transfus Med Hemother

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Objective: This review summarizes the neutropenias and transfusion reactions which are caused by granulocyte antibodies. The granulocyte antigens involved are described, and methods for the detection of granulocyte antibodies and antigens are discussed. Data Source: Review of the literature and results of studies performed at the Institut für Klinische Immunologie und Transfusionsmedizin. Selection Criteria: Peer-reviewed journals and papers relevant to the topic. Results: Granulocyte antibodies cause a variety of diseases, including alloimmune neonatal neutropenia, transfusion-related acute lung injury, refractoriness to granulocyte transfusions, febrile transfusion reactions, immune neutropenia after bone marrow transplantation, autoimmune neutropenia, and drug-induced immune neutropenia. A number of antigens has been described of which the NA1, NA2, NB1, SH, and the 5b antigens proved to be the most important ones. A combination of granulocyte agglutination and immunofluorescence tests together with a panel of typed cells represents currently the best means of detection. Conclusions: The detection and determination of granulocyte antibodies and antigens are essential for the diagnosis of immune neutropenias and of granulocyte antibody-induced transfusion reactions. Granulocyte cross-matching will improve the effects of granulocyte concentrates and avoid possible severe side effects.

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A Family with Allo-Immune Neonatal Neutropenia: Group-Specific Pathogenicity of Maternal Antibodies

Cited by 10 publications

References 8 publications

Abnormalities in leukocyte morphology and number

Abnormalities in leukocyte morphology and number

Prospective Evaluation of the Chemiluminescence Test for the Detection of Granulocyte Antibodies: Comparison with the Granulocyte Immunofluorescence Test

Granulocyte Antibody-Mediated Neutropenias and Transfusion Reactions

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