A flow chemiluminescence paper-based microfluidic device for detection of chromium (III) in water

Abstract

In this work, a solely gravity and capillary force-driven°ow chemiluminescence (GCF-CL) paper-based micro°uidic device has been proved for the¯rst time as a new platform for inexpensive, usable, minimally-instrumented dynamic chemiluminescence (CL) detection of chromium (III) [Cr(III)], where an appropriate angle of inclination between the loading and detection zones on the paper produces a rapid°ow of CL prompt solution through the paper channel. For this study, we use a cost-e®ective paper device that is manufactured by a simple wax screen-printing method, while the signal generated from the Cr(III)-catalyzed oxidation of luminol by H 2 O 2 is recorded by a low-cost and luggable CCD camera. A series of GCF-CL a®ecting factors have been evaluated carefully. At optimal conditions, two linear relationships between GCF-CL intensities and the logarithms of Cr(III) concentrations are obtained in the concentration ranges of 0.025-35 mg/L and 50-500 mg/L separately, with the detection limit of 0.0245 mg/L for a less than 30 s assay, and relative standard deviations (RSDs) of 3.8%, 4.5% and 2.3% for 0.75, 5 and 50 mg/L of Cr(III) (n ¼ 8). The above results indicate that the GCF-CL paper-based micro°uidic device possesses a receivable sensitivity, dynamic range, storage stability and reproducibility. Finally, the developed GCF-CL is utilized for Cr(III) detection in real water samples.

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