A Freshwater Fish-Based Diet Alleviates Liver Steatosis by Modulating Gut Microbiota and Metabolites: A Clinical Randomized Controlled Trial in Chinese Participants With Nonalcoholic Fatty Liver Disease

He, Kaiyin; Guo, Liliangzi; Tang, Huijun; Peng, Xiaojuan; Li, Juan; Feng, Shufen; Bie, Caiqun; Chen, Weiwei; Li, Yuting; Wang, Min; Tang, Shaohui

doi:10.14309/ajg.0000000000001885

Cited by 15 publications

(11 citation statements)

References 50 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Clinical trial was another hot topic detected in burst detection analysis. Among the current clinical trials, the most popular intervention is lifestyle intervention, including shifts in dietary patterns ( 38 – 40 ) and exercise ( 41 , 42 ), while intrahepatic fat loss, changes in serum biomarkers or gut microbiota are the most common primary outcomes. Additional supplemental dietary fiber ( 43 , 44 ), fecal microbiota transplantation ( 45 ), probiotics ( 46 ), and some antibiotics ( 47 , 48 ), have also received considerable attention.…”

Section: Discussionmentioning

confidence: 99%

“…The search strategies was as follows: TS= (NASH) OR TS= (nonalcoholic steatohepatitis) OR TS= (nonalcoholic steatohepatitis) OR TS= (NAFLD) OR TS= (non-alcoholic fatty liver disease) OR TS= (nonalcoholic fatty liver disease)OR TS=(MAFLD) OR TS= (metabolic associated fatty liver disease))AND ((TS= Liver (Topic) or TS= (hepatic*)) AND (TS= (gastro* micro*) or TS= (gastro* flora*) or TS=(gut micro*) or TS=(gut flora) or TS= (intestin * micro*) or TS=(intestin * flora))) OR (TS=(gut−liver axis) or TS=(gut liver axis)).We totally retrieved 2037 records. Then we eliminated invalid documents, including meeting abstracts (88), editorial materials (38), corrections (6), and letters (14). By this filter, 1891 records were included, of which articles (1209) accounted for 63.93% of the total, followed by reviews (682, 36.06%).…”

Section: Data Extractionmentioning

confidence: 99%

See 1 more Smart Citation

Global publication trends and research hotspots of the gut-liver axis in NAFLD: A bibliometric analysis

Yang

Liu

et al. 2023

Front. Endocrinol.

View full text Add to dashboard Cite

BackgroundNonalcoholic Fatty Liver Disease(NAFLD)refers to a spectrum of diseases ranging from simple liver steatosis to nonalcoholic steatohepatitis (NASH) and cirrhosis. Bidirectional cross-talk between the gut-liver axis plays an important role in the pathogenesis of NAFLD. To learn more about the gut-liver axis in NAFLD, this study aims to provide a comprehensive analysis from a bibliometric perspective.MethodLiterature related to the gut-liver axis in NAFLD from 1989 to 2022 was extracted from the Web of Science Core Collection. Based on Microsoft Excel, CiteSpace and Vosviewer, we conducted to analyze the number of publications, countries/regions, institutions, authors, journals, references, and keywords.ResultsA total of 1,891 literature since 2004 was included, with the rapid growth of the number of papers on the gut-liver axis in NAFLD annually. These publications were mainly from 66 countries and 442 institutions. Of the 638 authors analyzed, Bernd Schnabl was the one with the most publications, and Patrice D. Cani was the one with the most co-citations. International Journal of Molecular Sciences is the journal with the most articles published, and Hepatology is the journal with the most citations. The most common keywords are gut microbiota, inflammation, and insulin instance, which are current research hotspots. Short-chain fatty acid, in vitro, randomized controlled trial in clinical, and diabetes mellitus represent the research frontiers in this field and are in a stage of rapid development.ConclusionThis is the first study to conduct a comprehensive bibliometric analysis of publications related to the gut-liver axis in NAFLD. This study reveals that gut microbiota, inflammation, insulin resistance, short-chain fatty acids, and randomized controlled trial will be the hotspots and new trends in the gut-liver axis in NAFLD research, which could provide researchers with key research information in this field and is helpful for further exploration of new research directions.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Data Extractionmentioning

confidence: 99%

Global publication trends and research hotspots of the gut-liver axis in NAFLD: A bibliometric analysis

Yang

Liu

et al. 2023

Front. Endocrinol.

View full text Add to dashboard Cite

show abstract

“…The beneficial effects of PUFA intake included increasing ω-3 PUFA and decreasing of SFA and ω-6/ω-3 PUFA ratio. However, these effects may be masked by the deleterious effects of heme iron, resulting in an insignificant association between DFP2 and NAFLD ( 51 ). Our results suggested a diverse diet characterized by red meat intake may not increase NAFLD risk.…”

Section: Discussionmentioning

confidence: 99%

Associations between dietary fatty acid patterns and non-alcoholic fatty liver disease in typical dietary population: A UK biobank study

et al. 2023

View full text Add to dashboard Cite

Background and AimsDietary fatty acid composition is associated with non-alcoholic fatty liver disease (NAFLD). Few evidence had identified a clear role of dietary fatty acid composition of typical diet in NAFLD. We aimed to investigate the relationship between dietary patterns and NAFLD in populations with typical diets and to explore the effect of fatty acid composition in dietary patterns on NAFLD.MethodsPrincipal component analysis was used to identify 4 dietary patterns in UK Biobank participants. Logistic regression was used to estimate the association between dietary patterns and NAFLD. Mediation analysis was performed to evaluate the extent to which the relationship between dietary patterns and NAFLD was explained by dietary fatty acid combinations, as surrogated by serum fatty acids measured by nuclear magnetic resonance.ResultsA dietary fatty acid pattern (DFP1) characterized by “PUFA enriched vegetarian” was negatively associated with NAFLD risk. Serum fatty acids were significantly associated with DFP1 and NAFLD. Mediation analysis showed SFA (27.8%, p < 0.001), PUFA (25.1%, p < 0.001), ω-6 PUFA (14.3%, p < 0.001), LA (15.6%, p < 0.001) and DHA (10%, p < 0.001) had a significant indirect effect on the association between DFP1 and NAFLD. A dietary pattern characterized by “PUFA enriched carnivore” (DFP2) was not associated with NAFLD risk.ConclusionA “PUFA enriched vegetarian” dietary pattern with increased LA and DHA, may be beneficial for the treatment or prevention of NAFLD, while a “PUFA enriched carnivore” dietary pattern may not be harmful to NAFLD.

show abstract

“…62 Diet modulation has also been shown to be beneficial in reducing liver fat content (LFC). 63,64 There are nine additional lifestyle intervention trials investigating the efficacy of intermittent fasting or time-restricted feeding, low-carbohydrate or low-fat diet, aerobic exercise, and web-based care models in the treatment of NAFLD, which are either ongoing or completed in China (Table 3).…”

Section: Advances In Nafld/nash Treatment Regimens In Chinamentioning

confidence: 99%

“…In a randomized controlled trial (RCT) enrolling 220 Chinese patients with NAFLD, both vigorous exercise and moderate exercise were equally effective in reducing intrahepatic triglyceride content, and the effects were largely mediated via weight loss 62 . Diet modulation has also been shown to be beneficial in reducing liver fat content (LFC) 63,64 . There are nine additional lifestyle intervention trials investigating the efficacy of intermittent fasting or time‐restricted feeding, low‐carbohydrate or low‐fat diet, aerobic exercise, and web‐based care models in the treatment of NAFLD, which are either ongoing or completed in China (Table 3).…”

Section: Advances In Nafld/nash Treatment Regimens In Chinamentioning

confidence: 99%

Epidemiological characteristics and management of nonalcoholic fatty liver disease/nonalcoholic steatohepatitis in China: A narrative review

Liu

Hong

2023

Diabetes Obesity Metabolism

View full text Add to dashboard Cite

Aim With industrialization and spread of the westernized lifestyle, the number of people affected by non‐alcoholic fatty liver disease (NAFLD)/non‐alcoholic steatohepatitis (NASH) is growing rapidly in China; this has become a major public health concern. To better understand the burden and characteristics of NAFLD/NASH in China, we aim to perform a narrative review of the literature published in this field. Materials and Methods We carried out a comprehensive electronic search of five English‐language and three Chinese‐language databases, to identify studies regarding NAFLD or NASH published from inception to November 30, 2022. Epidemiological studies of NAFLD/NASH in China were particularly noticed and summarized. We also searched the http://www.clinicaltrials.gov and http://www.chictr.org.cn websites for the registered trials on the treatment of the disease led by Chinese investigators or located in China. Results The increasing rate of NAFLD prevalence in China is strikingly high, reaching more than twice that in western countries. The prevalence of NAFLD is nearly 30% of the general Chinese population, making it the leading cause of chronic liver diseases. The prevalence of NAFLD/NASH varies between provinces/regions, age groups, sexes, and individuals with different metabolic profiles. NAFLD co‐exists in many Chinese patients with chronic hepatitis B. Since 2020, more Chinese studies have used the term metabolic‐associated fatty liver disease (MAFLD), emphasizing the underlying metabolic disorders that occur concurrently with this disease. Several clinical trials involving lifestyle interventions, antidiabetic drugs, or traditional Chinese medicines, registered by Chinese investigators, have been completed or are ongoing. Moreover, several innovative targeted therapies developed in China are revolutionizing the treatment of NAFLD/NASH. Conclusions NAFLD has cast a heavy burden on the Chinese healthcare system. Chinese scholars are making efforts to achieve the optimal management of this disease.

show abstract

A Freshwater Fish-Based Diet Alleviates Liver Steatosis by Modulating Gut Microbiota and Metabolites: A Clinical Randomized Controlled Trial in Chinese Participants With Nonalcoholic Fatty Liver Disease

Cited by 15 publications

References 50 publications

Global publication trends and research hotspots of the gut-liver axis in NAFLD: A bibliometric analysis

Global publication trends and research hotspots of the gut-liver axis in NAFLD: A bibliometric analysis

Associations between dietary fatty acid patterns and non-alcoholic fatty liver disease in typical dietary population: A UK biobank study

Epidemiological characteristics and management of nonalcoholic fatty liver disease/nonalcoholic steatohepatitis in China: A narrative review

Contact Info

Product

Resources

About