A High Field Gradient Magnet for Magnetic Drug Targeting

Alexiou, Christoph; Diehl, D.; Henninger, Peter; Iro, Heinrich; Rockelein, R.; Schmidt, W.; Weber, Horst

doi:10.1109/tasc.2005.864457

Cited by 139 publications

(91 citation statements)

References 4 publications

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“…They provide an easy change in the location and current for fitting different tumor shapes and sizes. [664,665] A dynamic control of magnetic field strength and orientation enable a magnetic manipulator operating on an alternating magnetic field which is useful to target and guide the magnetic particles. [666] Electromagnets can produce good magnetic fields, stronger than permanent magnets, but they typically require liquid cooling to produce such fields.…”

Section: Strategies In Applying Magnetic Field For Mdtmentioning

confidence: 99%

Synthesis, Functionalization, and Design of Magnetic Nanoparticles for Theranostic Applications

Mosayebi

Kiyasatfar

Laurent

2017

Adv Healthcare Materials

203

171

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In order to translate nanotechnology into medical practice, magnetic nanoparticles (MNPs) have been presented as a class of non‐invasive nanomaterials for numerous biomedical applications. In particular, MNPs have opened a door for simultaneous diagnosis and brisk treatment of diseases in the form of theranostic agents. This review highlights the recent advances in preparation and utilization of MNPs from the synthesis and functionalization steps to the final design consideration in evading the body immune system for therapeutic and diagnostic applications with addressing the most recent examples of the literature in each section. This study provides a conceptual framework of a wide range of synthetic routes classified mainly as wet chemistry, state‐of‐the‐art microfluidic reactors, and biogenic routes, along with the most popular coating materials to stabilize resultant MNPs. Additionally, key aspects of prolonging the half‐life of MNPs via overcoming the sequential biological barriers are covered through unraveling the biophysical interactions at the bio–nano interface and giving a set of criteria to efficiently modulate MNPs' physicochemical properties. Furthermore, concepts of passive and active targeting for successful cell internalization, by respectively exploiting the unique properties of cancers and novel targeting ligands are described in detail. Finally, this study extensively covers the recent developments in magnetic drug targeting and hyperthermia as therapeutic applications of MNPs. In addition, multi‐modal imaging via fusion of magnetic resonance imaging, and also innovative magnetic particle imaging with other imaging techniques for early diagnosis of diseases are extensively provided.

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Section: Strategies In Applying Magnetic Field For Mdtmentioning

confidence: 99%

Synthesis, Functionalization, and Design of Magnetic Nanoparticles for Theranostic Applications

Mosayebi

Kiyasatfar

Laurent

2017

Adv Healthcare Materials

203

171

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“…[6][7][8] Hence, the majority of previous systems have been designed to attract therapeutic particles to target regions. [9][10][11][12][13][14][15] Because two or more magnets can be utilized to push particles, 16 the method can be applied to therapies directed toward the back of the eye 6,7 and the inner ear. [17][18][19] However, there is a difficulty associated with magnetic focusing in central targets, which is explained in part by Samuel Earnshaw's 1842 theorem.…”

Section: Introductionmentioning

confidence: 99%

Simulation studies of a novel electromagnetic actuation scheme for focusing magnetic micro/nano-carriers into a deep target region

Zhang

Hoshiar

et al. 2017

AIP Advances

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The ability to focus spherical particles (SPPs) to a deep tumor region remains one of the major challenges in magnetic drug targeting (MDT). A number of studies have attempted to overcome this problem using fast magnetic pulses and ferromagnetic rods. However, focusing of the SPPs in the deep body organs remains unsolved using existing schemes. In this paper, we propose a novel electro-magnetic actuation scheme for pushing and focusing SPPs. The simulation results demonstrate that the newly proposed actuation scheme can focus SPPs to a target surface region, inside of a block filled with an environment that has the characteristics of blood. We then investigated the effects of the proposed focusing scheme in realistic blood vessels with a maximum length of about 10–12 cm. The results show that SPPs of 500 nm can be concentrated onto a target tumor region with up to 97.9% efficiency. The proposed electromagnetic actuation scheme can maximize the efficiency of MDT, while minimizing the side effects of drugs in other tissues.

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“…The force density of the linear actuator is enhanced by shaping and profiling the field at the pole face using a shaded pole technique [2,3]. Additional relevant work is [4] which makes use of a single shaped magnetic pole in a magnetic drug targeting system. This directs but does not concentrate the field.…”

Section: Introductionmentioning

confidence: 99%

Synthesis of a Magnetic Field Concentrated in One Dimension

Sessel¹,

Hofsajer²

2014

PIER

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Abstract-The focusing of a magnetic field, at low frequencies, in the very near field is difficult as flux lines naturally tend to disperse. It is not possible to use antenna array techniques due to large wavelengths at low frequencies. A method for synthesizing a concentrated magnetic field in a large air gap between two magnetic poles is presented. The focusing effect is brought about by the inclusion of side poles, adjacent to each of the main poles. Through the correct dimensioning of the side poles' reluctances and relative magneto-motive forces it is possible to focus the field in the center of the gap. General design curves for normalized parameters, determined via finite element modelling, are presented. A scale model is experimentally verified.

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A High Field Gradient Magnet for Magnetic Drug Targeting

Cited by 139 publications

References 4 publications

Synthesis, Functionalization, and Design of Magnetic Nanoparticles for Theranostic Applications

Synthesis, Functionalization, and Design of Magnetic Nanoparticles for Theranostic Applications

Simulation studies of a novel electromagnetic actuation scheme for focusing magnetic micro/nano-carriers into a deep target region

Synthesis of a Magnetic Field Concentrated in One Dimension

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