A Histological Study of Human Derived Tooth-Hydroxyapatite (THA)

Abstract

Different types of bone-graft substitutes have been developed and are in the market worldwide to eliminate the drawbacks of autogenous grafting. They vary in composition, strength, osteoinductive and osteoconductive properties, mechanism and rates by which they are resorbed and remodelled. Tooth derived hydroxyapatite (THA) is a novel biomaterial. This study was performed to determine the histological properties of THA on animals. A commercial coralline HA (CHA, Proosteon 200, Interpore Cross, USA) was used as control material. 20 sheeps were used and divided into 2 groups. Human THA (Group A) and CHA (Group B) materials were implanted to the tibiae of 10 sheeps for each group. The histological examinations of surrounding bone response were done 12 weeks after implantation. There was no significant difference histologically between group A and B. All materials were found to be surrounded by new bone tissue. THA was found to be as efficient as the standard CHA on histological basis. In addition, economical production of THA should be taken into consideration. Therefore, THA may be a viable alternative on bone grafting provided that clinical trials will be completed.

Dissolution of Human Teeth-Derived Hydroxyapatite

“…13,14 Furthermore, in vivo study by Oktar et al suggested a potential of teeth derived HA as a safe bone graft biomaterial. 34 However, dissolving behavior of teeth derived HA and comparison with artificially prepared HA have never been examined.…”

Highly Bioactive Porous Composite Scaffolds of Bovine Hydroxyapatite (BHA-Ti, BHA-TiO₂, BHA-Li₂O)

“…Doping with ceramic oxides, such as Ti 2 O or Li 2 O, overcomes the problem of chemical-nature mismatch between HA and the doping components [10,11]. Hence, good chemical affinity and possible diffusion [10,11] resulted in no microcracks in the case of HA-doping with these two oxides (Figs. 1b, c, d).…”

Comparision of osteoconductivity of biologic and artificial synthetic hydroxyapatite in experimental mastoid obliteration

“…A positive effect of BHA in the early acceleration of bone formation was found. Oktar et al suggested that BHA derived from the teeth had potential as a safe bone graft material [13]. In general, physical and chemical properties of HA materials are important factors affecting the dissolution process [13][14][15][16].…”