A low-protein, high carbohydrate diet induces increase in serum adiponectin and preserves glucose homeostasis in rats

Ceolin, Patrícia; França, Suélem Aparecida de; Froelich, Mendalli; Santos, Maísa Pavani dos; Pereira, Mayara Peron; Queiroz, Thaís S; Silva, Flávia H.S. da; Lisboa, Patrícia Cristina; Andrade, Claudia Marlise Balbinotti; Baviera, Amanda Martins; Kawashita, Nair Honda

doi:10.1590/0001-3765201920180452

Cited by 6 publications

(14 citation statements)

References 37 publications

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“…Yagi et al found that a low-protein diet significantly elevated serum adiponectin level and also increased the amount of adiponectin secreted by adipocytes isolated from white adipose tissue ( 41 ). Also, Ceolin et al in an animal model study showed that serum adiponectin level was higher in animals fed with a low protein diet than standard protein diet ( 42 ). The results of a study on older women participating in a resistance-based exercise program showed that women with a high protein diet had significantly higher adiponectin content compared to those with a high carbohydrate diet ( 43 ).…”

Section: Discussionmentioning

confidence: 99%

Association of High Dietary Acid Load With the Risk of Cancer: A Systematic Review and Meta-Analysis of Observational Studies

et al. 2022

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ObjectiveThis study aimed to determine the relationship between the high dietary acid load (DAL) and the risk of cancer.MethodsFive databases of PubMed, Web of Sciences, Scopus, Cochrane Library, and Google Scholar was searched to elicit original studies on humans, up to June 2021. Quality of the articles, risk of bias, and heterogeneity were assessed. A random-effects meta-analysis model was applied to estimate pooled effect size with a 95% confidence interval. Sensitivity analysis was performed using a fixed-effects model. Subgroup analyses were carried out based on gender, age, type of cancer, and type of DAL assessment indicator.ResultsSeventeen effect sizes from 10 articles were included in the analysis. Overall, individuals with the highest DAL were associated with a 66% increased risk of cancer compared to those with the lowest DAL (p < 0.001]. The risk of cancer increased 41% (p < 0.001) and 53% (p = 0.03) by high PRAL and NEAP, respectively. High DAL was associated with 32% (p < 0.001) and 79% (p < 0.001) increased risk of breast and colorectal cancers, respectively. High DAL was associated with 32% (p = 0.001) and 76% (p = 0.007) increased risk of cancer incident in women and men, respectively. The risk of cancer incident increased 35% (p < 0.001) and 49% (p < 0.001) at age ≤ and > of 50, respectively.ConclusionHigh DAL may be associated with a higher risk of cancer incidence not only in the whole studied population but also across cancer types, both genders, both DAL assessment indicators, and also among both high- and low-risk age groups for cancer.

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Section: Discussionmentioning

confidence: 99%

Association of High Dietary Acid Load With the Risk of Cancer: A Systematic Review and Meta-Analysis of Observational Studies

et al. 2022

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“…The weight loss observed in HCD in respect to the ND group may be partially explained by the lower food consumption (constituted by 13.2% protein) observed in this study. This dietary deficiency can decrease muscle mass by increasing thermogenesis in adipose tissue [ 31 ], and induce an increased insulin resistance which is known to reduce muscle protein synthesis [ 32 ]. Our findings agree with previous studies where no weight gain has been observed after HCD [ 33 , 34 ].…”

Section: Discussionmentioning

confidence: 99%

Effects of Non-Nutritive Sweeteners on Energy Intake, Body Weight and Postprandial Glycemia in Healthy and with Altered Glycemic Response Rats

Ramos-García

Blé-Castillo

García-Vázquez

et al. 2021

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The aim of this study was to evaluate the effects of non-nutritive sweeteners (NNS) consumption on energy intake, body weight and postprandial glycemia in healthy and with altered glycemic response rats. Animals on normal diet (ND) or high-fat diet (HFD) were divided to receive NNS (sucralose, aspartame, stevia, rebaudioside A) or nutritive sweeteners (glucose, sucrose) for 8 weeks. The NNS were administered at doses equivalent to the human acceptable daily intake (ADI). A test using rapidly digestible starch was performed before and after treatments to estimate glycemic response. No effects of NNS consumption were observed on energy intake or body weight. Sucrose provoked an increased fluid consumption, however, energy intake, and weight gain were not altered. In ND, no effects of NNS on glycemic response were observed. In HFD, the glycemic response was increased after sucralose and stevia when only the final tolerance test was considered, however, after including the baseline test, these results were no longer significant compared to glucose. These findings provide further evidence suggesting that at the recommended doses, NNS do not alter feeding behavior, body weight or glycemic tolerance in healthy and with altered glycemic rats.

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“…Increased maternal food intake after PR during gestation has been well documented and has emerged as a mechanism to compensate for the lack of amino acid supply [ 33 , 34 , 35 , 36 ]. We showed that food intake was drastically decreased during the second half of lactation, which could deeply alter breast milk quality and body composition, given the high energy requirements for nursing [ 37 ].…”

Section: Discussionmentioning

confidence: 99%

Maternal Protein Restriction in Rats Alters Postnatal Growth and Brain Lipid Sensing in Female Offspring

et al. 2023

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Perinatal nutrition is a key player in the susceptibility to developing metabolic diseases in adulthood, leading to the concept of “metabolic programming”. The aim of this study was to assess the impact of maternal protein restriction during gestation and lactation on glucose homeostasis and eating behaviour in female offspring. Pregnant rats were fed a normal or protein-restricted (PR) diet and followed throughout gestation and lactation. Body weight, glucose homeostasis, and eating behaviour were evaluated in offspring, especially in females. Body weight gain was lower in PR dams during lactation only, despite different food and water intakes throughout gestation and lactation. Plasma concentration of leptin, adiponectin and triglycerides increased drastically before delivery in PR dams in relation to fat deposits. Although all pups had identical birth body weight, PR offspring body weight differed from control offspring around postnatal day 10 and remained lower until adulthood. Offspring glucose homeostasis was mildly impacted by maternal PR, although insulin secretion was reduced for PR rats at adulthood. Food intake, satiety response, and cerebral activation were examined after a lipid preload and demonstrated some differences between the two groups of rats. Maternal PR during gestation and lactation does induce extrauterine growth restriction, accompanied by alterations in maternal plasma leptin and adiponectin levels, which may be involved in programming the alterations in eating behaviour observed in females at adulthood.

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A low-protein, high carbohydrate diet induces increase in serum adiponectin and preserves glucose homeostasis in rats

Abstract: How to cite: CeOlIN P eT Al. 2019. A low-protein, high carbohydrate diet induces increase in serum adiponectin and preserves glucose homeostasis in rats. An Acad Bras Cienc 91: e20180452.

Cited by 6 publications

References 37 publications

Association of High Dietary Acid Load With the Risk of Cancer: A Systematic Review and Meta-Analysis of Observational Studies

Association of High Dietary Acid Load With the Risk of Cancer: A Systematic Review and Meta-Analysis of Observational Studies

Effects of Non-Nutritive Sweeteners on Energy Intake, Body Weight and Postprandial Glycemia in Healthy and with Altered Glycemic Response Rats

Maternal Protein Restriction in Rats Alters Postnatal Growth and Brain Lipid Sensing in Female Offspring

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