A mechanistic approach to understanding conjugated linoleic acid's role in inflammation using murine models of rheumatoid arthritis

Bütz, Daniel E.; Li, Guangming; Huebner, Shane M.; Cook, Mark E.

doi:10.1152/ajpregu.00005.2007

Cited by 37 publications

(43 citation statements)

References 53 publications

(60 reference statements)

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“…The positive effects of CLA on renal pathology are consistent with other studies of CLA in proliferative and inflammatory disorders [16,17,18,19]. These effects may be mediated in part via reduced prostanoid production, as CLA exposure in these rats [20], as well as in other tissues [24,25,26,27], can result in diminished prostanoid production.…”

Section: Discussionsupporting

confidence: 86%

“…CLA has been shown to exert anti-inflammatory and antiproliferative properties [16,17,18,19], rendering it potentially useful as a nutritional intervention strategy to slow renal disease progression. A study conducted on weanling Han:SPRD- cy rats determined that a diet containing 1% (by weight) CLA reduces renal inflammation and fibrosis [20], two important markers of renal disease progression.…”

Section: Introductionmentioning

confidence: 99%

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Effects of Dietary Conjugated Linoleic Acid in Advanced Experimental Polycystic Kidney Disease

Scatliff

Bankovic-Calic

Ogborn³

et al. 2008

Nephron Exp Nephrol

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Background/Aims: Several dietary interventions, including those involving conjugated linoleic acid (CLA), slow progression of polycystic kidney disease (PKD) when initiated in the early stages of disease in Han:SPRD-cy rats. However, in humans, kidney disease is often undetected until extensive renal injury has developed. The objective of this study therefore was to determine whether initiating dietary CLA intervention in advanced PKD would slow disease progression. Methods: Adult male Han:SPRD-cy rats with advanced kidney disease were fed diets with or without 1% CLA for 16 weeks. Disease progression was assessed by serum urea, proteinuria, and creatinine clearance, and morphological and immunohistochemical measurements for pathologic change. Results: Renal injury was lower in the PKD rats given CLA compared to those given the control diet as indicated by a reduction in inflammation (42% less), fibrosis (28% less), oxidative damage (30% less) and proliferating cells (35% less). Diet had no effect on body, kidney, or liver weight, serum urea, serum creatinine, creatinine clearance, proteinuria, or cyst volume. Conclusions: Late dietary intervention with CLA reduced some disease-associated pathologies, but did not alter renal function in adult Han:SPRD-cy rats. The long-term anti-inflammatory, antioxidant, and antiproliferative benefits of CLA in advanced kidney disease remain to be determined.

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Section: Discussionsupporting

confidence: 86%

Section: Introductionmentioning

confidence: 99%

Effects of Dietary Conjugated Linoleic Acid in Advanced Experimental Polycystic Kidney Disease

Scatliff

Bankovic-Calic

Ogborn³

et al. 2008

Nephron Exp Nephrol

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“…The issue still remains relevant in the management of dairy cows, therefore additional tools able to modulate inflammatory response, avoiding negative aspects and keeping positive ones, are needed. In this respect, potential candidates might be the conjugated linoleic acid (Butz et al 2007;Ringseis et al 2008), phytoextracts (Choi et al, 2003;, and polyunsaturated fatty acids (Calder, 2006a;Ballou et al, 2009), in particular the long chain ω3.…”

Section: Introductionmentioning

confidence: 99%

Attenuation of inflammatory response phenomena in periparturient dairy cows by the administration of an ω3 rumen protected supplement containing vitamin E

Trevisi

Grossi

Piccioli-Cappelli

et al. 2011

Italian Journal of Animal Science

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“…and the interphalangeal articulations of rat feet were excised for subsequent biochemical and histological analyses. The arthritis score counting was based on a scale of 0 to 4 using the criteria in a blinded manner (7). Results are all expressed as the mean ± S.E.M.…”

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confidence: 99%

Amelioration by the Natural Polyamine Spermine of Cartilage and Bone Destruction in Rats With Collagen-Induced Arthritis

et al. 2012

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Abstract. We investigated pharmacological properties of naturally occurring polyamines on cartilage and bone destruction seen in joints of rats with collagen-induced arthritis (CIA). Daily supplementation of spermine (SPM), but not spermidine, significantly inhibited increases in the hind paw volume and arthritis score in CIA rats, in addition to the increased mRNA expression of receptor activator of nuclear factor-κB ligand in both cartilage and synovial tissues. Histological analysis clearly revealed a drastic prevention by SPM of the cartilage and bone destruction in synovial joints of CIA rats. Particular natural polyamines would be beneficial for the prophylaxis of synovial joint destruction in rheumatoid arthritis.

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A mechanistic approach to understanding conjugated linoleic acid's role in inflammation using murine models of rheumatoid arthritis

Abstract: Butz DE, Li G, Huebner SM, Cook ME. A mechanistic approach to understanding conjugated linoleic acid's role in inflammation using murine models of rheumatoid arthritis.

Cited by 37 publications

References 53 publications

Effects of Dietary Conjugated Linoleic Acid in Advanced Experimental Polycystic Kidney Disease

Effects of Dietary Conjugated Linoleic Acid in Advanced Experimental Polycystic Kidney Disease

Attenuation of inflammatory response phenomena in periparturient dairy cows by the administration of an ω3 rumen protected supplement containing vitamin E

Amelioration by the Natural Polyamine Spermine of Cartilage and Bone Destruction in Rats With Collagen-Induced Arthritis

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