A metabolomic investigation on arsenic-induced toxicological effects in the clam Ruditapes philippinarum under different salinities

Wu, Huifeng; Zhang, Xingyan; Wang, Qing; Li, Lianzhen; Ji, Chenglong; Liu, Xiaoli; Zhao, Jianmin; Yin, Xiuli

doi:10.1016/j.ecoenv.2012.02.022

Cited by 49 publications

(24 citation statements)

References 46 publications

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“…In addition, the depleted lactate displayed the reduced anaerobiosis in the shrimps from LZB site. In arsenate-exposed clam R. philippinarum, the similar alteration of BCAAs and tyrosine was also observed (Wu et al, 2013b). Since the shrimp samples from LZB site were contaminated by arsenic, these amino acids could be used as biomarkers of arsenic contamination in shrimp C. affinis.…”

Section: H Nmrmentioning

confidence: 72%

Impact of metal pollution on shrimp Crangon affinis by NMR-based metabolomics

Wang

et al. 2016

Marine Pollution Bulletin

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a b s t r a c t a r t i c l e i n f oBoth cadmium and arsenic are the important metal/metalloid pollutants in the Bohai Sea. In this work, we sampled the dominant species, shrimp Crangon affinis, from three sites, the Middle of the Bohai Sea (MBS), the Yellow River Estuary (YRE) and the Laizhou Bay (LZB) along the Bohai Sea. The concentrations of metals/metalloids in shrimps C. affinis indicated that the YRE site was polluted by Cd and Pb, while the LZB site was contaminated by As. The metabolic differences between shrimps C. affinis from the reference site (MBS) and metal-pollution sites (YRE and LZB) were characterized using NMR-based metabolomics. Results indicated that the metal pollutions in YRE and LZB induced disturbances in osmotic regulation and energy metabolism via different metabolic pathways. In addition, a combination of alanine and arginine might be the biomarker of Cd contamination, while BCAAs and tyrosine could be the biomarkers of arsenic contamination in C. affinis.

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Section: H Nmrmentioning

confidence: 72%

Impact of metal pollution on shrimp Crangon affinis by NMR-based metabolomics

Wang

et al. 2016

Marine Pollution Bulletin

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“…Although there are several data about the effects of the environmental stress on the clam metabolism, the adaptation to the salinity change has remained largely unknown (Liu et al, 2011;Zhang et al, 2011aZhang et al, ,2011bZhang et al, ,2011cWu et al, 2013). The bivalves change ion and intracellular free amino acid concentrations to maintain inorganic ion strength (Pierce and Amende, 1981;Pierce, 1982).…”

Section: Introductionmentioning

confidence: 99%

Dynamic changes in the accumulation of metabolites in brackish water clam Corbicula japonica associated with alternation of salinity

Koyama

Okamoto

Watanabe

et al. 2015

Comparative Biochemistry and Physiology Part B: Biochemistry an

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“…Among these analytical techniques, 1 H NMR spectroscopy has received much attention for its advantages upon the simultaneous analysis of the low molecularweight metabolites in a short time Lindon et al, 2000;Picone et al, 2011). NMR-based metabolomics has been widely applied in multiple areas including biology (Nicholson et al, 1999), medicine (Dunn et al, 2011), toxicology (Kokushi et al, 2010;Li et al, 2006;Williams et al, 2009Williams et al, , 2011Williams et al, , 2014Wang, 2010, 2011;Wu et al, 2013bWu et al, , 2013c, immunology (Liu et al, , 2014 and nutriology (Collino et al, 2011). Regarding the temperature modulated marine organism, studies at the metabolic level have also been carried out in certain marine animals.…”

Section: Introductionmentioning

confidence: 99%