A method to design biomimetic scaffolds for bone tissue engineering based on Voronoi lattices

Fantini, Massimiliano; Curto, Marco; Crescenzio, Francesca De

doi:10.1080/17452759.2016.1172301

Cited by 102 publications

(57 citation statements)

References 49 publications

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“…The delicate structures could easily be removed from the fluid‐gel bed following gelation without damage to the scaffolds. These elaborate designs are often favored in the manufacture of implantable scaffolds as they are conducive to diffusion and vascular infiltration, thus reducing the emergence of hypoxic or necrotic regions . To display the system's capacity to print large bulk structures, a T7 intervertebral disc was manufactured (Figure B).…”

Section: Resultsmentioning

confidence: 99%

Fabrication of Complex Hydrogel Structures Using Suspended Layer Additive Manufacturing (SLAM)

Senior

Cooke

Grover

et al. 2019

Adv Funct Materials

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There have been a number of recently reported approaches for the manufacture of complex 3D printed cell-containing hydrogels. Given the fragility of the parts during manufacturing, the most successful approaches use a supportive particulate gel bed and have enabled the production of complex gel structures previously unattainable using other 3D printing methods. The supporting gel bed provides protection to the fragile printed part during the printing process, preventing the structure from collapsing under its own weight prior to crosslinking. Despite the apparent similarity of the particulate beds, the way the particles are manufactured strongly influences how they interact with one another and the part during fabrication, with implications to the quality of the final product. Recently, the process of suspended layer additive manufacture (SLAM) is demonstrated to create a structure that recapitulated the osteochondral region by printing into an agarose particulate gel. The manufacturing process for this gel (the application of shear during gelation) produced a self-healing gel with rapid recovery of its elastic properties following disruption. Here, the physical characteristics of the supporting fluid-gel matrix used in SLAM are explored, and compared to other particulate gel supporting beds, highlighting its potential for producing complex hydrogel-based parts.

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Section: Resultsmentioning

confidence: 99%

Fabrication of Complex Hydrogel Structures Using Suspended Layer Additive Manufacturing (SLAM)

Senior

Cooke

Grover

et al. 2019

Adv Funct Materials

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“…A limited class of three‐dimensional unit cell types can be packed together to create a tessellated cellular structure. Several studies have been carried out on selecting the appropriate unit cell types to manufacture biomimetic scaffolds aimed for bone tissue engineering . Cube, rhombic dodecahedron, tetrakaidecahedrons, Weaire–Phelan, and diamond are the most popular unit cell types which have been investigated mechanically before.…”

Section: Introductionmentioning

confidence: 99%

“…Several studies have been carried out on selecting the appropriate unit cell types to manufacture biomimetic scaffolds aimed for bone tissue engineering. 14,15 Cube, 1,16,17 rhombic dodecahedron, 2,16,18,19 tetrakaidecahedrons, [20][21][22] Weaire-Phelan, 23,24 and diamond 12,16 are the most popular unit cell types which have been investigated mechanically before. Other micro-lattice structures such as body-centred cubic structure (BCC), 25 body-centered cubic with vertical pillars (BCC-Z), 25 rhombicuboctahedron, 26 truncated cube, 27 facet-centered cubic with vertical pillars (FCC-Z), 28,29 and truncated cuboctahedron 30 have also been investigated by different researchers.…”

Section: Introductionmentioning

confidence: 99%

Comparison of elastic properties of open‐cell metallic biomaterials with different unit cell types

et al. 2017

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Additive manufacturing techniques have made it possible to create open-cell porous structures with arbitrary micro-geometrical characteristics. Since a wide range of micro-geometrical features is available for making an implant, having a comprehensive knowledge of the mechanical response of cellular structures is very useful. In this study, finite element simulations have been carried out to investigate the effect of structure unit cell type (cube, rhombic dodecahedron, Kelvin, Weaire-Phelan, and diamond), cross-section type (circular, square, and triangular), strut length, and relative density on the Young's modulus, shear modulus, yield stress, shear yield stress, and Poisson's ratio of open-cell tessellated cellular structures. It was desired to see whether or not and to what extent each of the aforementioned parameters affect the mechanical properties of a porous structure. It was seen that the strut cross-section type does not have a considerable effect on the structure Young's modulus while its effect on the structure yield stress is significant. The strut length was not effective on the mechanical properties if the relative density was kept constant. It was also observed that the structure unit cell type and relative density have a considerable effect on the elastic properties. The highest and the lowest stiffness and strength belonged to the cube and diamond unit cell types, respectively. The rhombic dodecahedron structure with circular cross-section had a high yielding strength (second among all the cases) while its Young's modulus was relatively low. Therefore, it is the best choice for applications with low stiffness requirements, such as biomedical implants. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 106B: 386-398, 2018.

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“…As shown in Figure a, three main components of bioprinting technology are: living organisms which mainly refers to living cells; bioink which mostly are made from hydrogel or cell culture medium . Growth factors may be added to bioink to promote cell growth and formation such as connective tissue growth factor or fibroblast promoting growth factor; and bioprinter which is the robotic system that has been used to generate CAD file (from CT scan or design software) and to fabricate the tissue structure …”

Section: Bioprinting Technology: An Overviewmentioning

confidence: 99%

Bioprinting of Thermoresponsive Hydrogels for Next Generation Tissue Engineering: A Review

Suntornnond

Chua

2016

Macromol. Mater. Eng.

159

149

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Bioprinting is a breakthrough technology that integrates living cells, biomaterials, and a robotic dispensing system to create complex structures that mimic original tissues and organs. One of the main components of bioprinting is bioink and hydrogel is essential in bioink formulation. In bioprinting, hydrogel should have good biocompatibility, provide good resolution, and have sufficient mechanical strength to support printed structures. Recently, thermoresponsive hydrogels have gained more and more attention due to their unique characteristic of tunable sol-gel (liquid to solid phase) transition when temperature is changed, and many biomedical applications from drug delivery devices to tissue scaffolds have demonstrated the potentials of bioprinted thermosresponsive constructs. In this review, we discuss bioprintable thermoresponsive hydrogels with a particular focus on their gelation mechanisms, fabrication strategies using bioprinter and applications. The future prospects of the bioprinting-based use of thermoresponsive hydrogels for next generation tissue engineering have also been discussed.

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A method to design biomimetic scaffolds for bone tissue engineering based on Voronoi lattices

Cited by 102 publications

References 49 publications

Fabrication of Complex Hydrogel Structures Using Suspended Layer Additive Manufacturing (SLAM)

Fabrication of Complex Hydrogel Structures Using Suspended Layer Additive Manufacturing (SLAM)

Comparison of elastic properties of open‐cell metallic biomaterials with different unit cell types

Bioprinting of Thermoresponsive Hydrogels for Next Generation Tissue Engineering: A Review

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