A microfluidic system with volume sensor and dielectric glucose sensor for continuous glucose monitoring

Abstract

We present a microfluidic system for interstitial fluid (ISF) transdermal extraction, ISF volume measurement, and dielectric glucose sensing towards the application of continuous glucose monitoring. This device significantly incorporates a MEMS volume sensor, which measures extracted ISF volume via conductance monitoring, and integrates a MEMS dielectric glucose sensor, which specifically measures glucose concentrations in the transdermally extracted ISF via affinity binding. The volume sensor and the glucose sensor in the microfluidic system are characterized. The feasibility of the single-chip device for automated, accurate, and continuous monitoring of subcutaneous ISF glucose concentrations is verified.

Continuous glucose monitoring: a systematic review of sensor systems and prospects

“…mM in Vaddiraju et al (2015), Xiao et al (2015), Yoon et al (2016), Lee et al (2009) and Yoon et al (2015), respectively. R 2 curve fitting is found to be 0.99509, >0.98, 0.92514 and 0.999 in Li et al (2012), Sun et al (2015), Lu et al (2016), and Li et al (2013), respectively. Similarly, the glucose concentration sensitivity level was found promising as 2-22, 0-20, 0-40 and 0-20 mM in Croce et al (2013), Tathireddy et al (2010), Ahmadi and Jullien (2009) and Nazari et al (2014), respectively.…”

“…X. Huang et al and D. Li et al proposed a similar type of microfluidic system for interstitial fluid (ISF) transdermal extraction toward CGM. Both these techniques implement PAA-ran-PAAPBA polymer to design the glucose sensor (Huang et al , 2012; Li et al , 2013). Figure 12 presents the MEMS glucose sensor based on the work of Huang et al (2012).…”