A model of the dual effect of gadopentetate dimeglumine on dynamic brain MR images

Barbier, Emmanuel; Boer, Jacques A. den; Peters, Anton R.; Rozeboom, A.R.; Sau, Jacques; Bonmartin, A.

doi:10.1002/(sici)1522-2586(199909)10:3<242::aid-jmri4>3.0.co;2-h

Cited by 44 publications

(33 citation statements)

References 34 publications

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“…This is not ideal, since T1-weighted techniques typically do not have the temporal and spatial resolution of T2*-weighted echo-planar imaging (EPI). In another approach, both T1-and T2*-sensitive images are simultaneously acquired by dual gradient-echo dynamic imaging (10,11), but this method requires a tradeoff between the temporal and spatial resolution. Conversely, contrast leakage into the extravascular space alters signal on T2*-weighted images so that it may be possible to derive vascular permeability by analysis of agent recirculation and equilibration during the latter time points of a dynamic T2*-weighted series (8).…”

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confidence: 99%

“…Note that in Weisskoff's methods, back-flux of the contrast agent from extravascular extracellular space (EES) to the vascular space was neglected; at high values of permeability, this can cause estimates to be biased toward lower values (6). Several other methodologies have also been proposed to simultaneously quantify permeability and CBV from dual gradient-echo dynamic images (10,11). Again, in these studies, the back-flux of the tracer was neglected.…”

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confidence: 99%

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Estimate of vascular permeability and cerebral blood volume using Gd‐DTPA contrast enhancement and dynamic T2*‐weighted MRI

Cao

Shen

Chenevert

et al. 2006

Magnetic Resonance Imaging

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Purpose: To develop a numerical approach for estimation of vascular permeability from dynamic T2*-weighted imaging, a technique routinely used to measure cerebral blood volume (CBV) and flow in gliomas. Materials and Methods:This study describes a process for estimating both the gadolinium diethylenetriamine pentaacetic acid (Gd-DTPA) transvascular transfer constant and CBV from dynamic T2*-weighted images. The algorithm was applied to data from the brains of 12 patients with grade IV gliomas. The stability of the method was assessed. Estimates of CBV by this technique were compared to those of the conventional method. Results:The algorithm was found to be insensitive to noise and to generate stable voxel-by-voxel estimates of permeability and CBV. Conclusion:Using a single imaging acquisition, the three most important vascular properties, CBV, cerebral blood flow (CBF), and permeability, can be estimated. This approach may have potential in clinical evaluation of patients with brain tumor or acute ischemic stroke.

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confidence: 99%

Estimate of vascular permeability and cerebral blood volume using Gd‐DTPA contrast enhancement and dynamic T2*‐weighted MRI

Cao

Shen

Chenevert

et al. 2006

Magnetic Resonance Imaging

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“…Perfusion analysis was performed according to the methods described by Barbier et al (1999) where signal intensities from the long and short echoes were combined to produce maps of R * 2 , which eliminates the undesirable 'T 1 shine through' effect commonly seen in susceptibility-contrast techniques. Gamma variate functions were fitted to the R * 2 time courses using a Levenberg-Marquardt algorithm.…”

Section: Discussionmentioning

confidence: 99%

“…Although it has not been explicitly shown here, DC-EPIK offers a degree of flexibility in that the SPARSE factor, the keyhole factor and the oversampling factor are adjustable parameters which influence the temporal resolution and the achievable degree of immunity from susceptibility artefacts. Because DC-EPIK intrinsically acquires two images, registration of these images is inherent; this is, of course, applicable to other dual echo sequences (Barbier et al 1999, Miyati et al 1997, Vonken et al 2000 also, but DC-EPIK is faster since it is based on EPI rather than FLASH. The acquisition of an independent keyhole during each shot ensures that the contrast-to-noise of each reconstructed image is, to all practical intents, an independent measure.…”

Section: Discussionmentioning

confidence: 99%

Dual-contrast echo planar imaging with keyhole: application to dynamic contrast-enhanced perfusion studies

Zaitsev¹,

d’Arcy²,

Collins³

et al. 2005

Phys. Med. Biol.

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A new EPI-based method is presented which features optimized sampling of k-space enabling the integrated acquisition of two gradient echo images. The first of these images is predominantly T 1 weighted and the second is T * 2 weighted. The new method combines echo sharing of sparsely acquired high spatial frequency components with the keyhole technique and half-Fourier image reconstruction. The feasibility of acquiring high spatial and temporal resolution in vivo images for perfusion mapping is demonstrated. In contrast to most current perfusion methods, which acquire the T 1 -and T * 2 -weighted images in separate acquisitions, the need for image co-registration here is obviated since both sets of images are EPI-based and are acquired within the same measurement.

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“…14,15 The use of dynamic multi-echo imaging for combined DCE-and DSC-MRI analysis have also been demonstrated in brain tumors. [16][17][18] The aim of this pilot study was to implement a dynamic contrast-based multi-echo MRI sequence in the assessment of rectal cancer, and to evaluate associations between histopathologic data and the attainable DCE-and DSC-MRI parameters.…”

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confidence: 99%

Dynamic multi-echo DCE- and DSC-MRI in rectal cancer: Low primary tumor K^trans and ΔR2* peak are significantly associated with lymph node metastasis

Grøvik

Redalen

Storås

et al. 2016

J. Magn. Reson. Imaging

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Purpose: To implement a dynamic contrast-based multi-echo MRI sequence in assessment of rectal cancer and evaluate associations between histopathologic data and the acquired dynamic contrast-enhanced (DCE) and dynamic susceptibility contrast (DSC) -MRI parameters. Materials and Methods: This pilot study reports results from 17 patients with resectable rectal cancer. Dynamic contrast-based multi-echo MRI (1.5T) was acquired using a three-dimensional multi-shot EPI sequence, yielding both DCE-and DSC-data following a single injection of contrast agent. The Institutional Review Board approved the study and all patients provided written informed consent. Quantitative analysis was performed by pharmacokinetic modeling on DCE data and tracer kinetic modeling on DSC data. Mann-Whitney U-test and receiver operating characteristics curve statistics was used to evaluate associations between histopathologic data and the acquired DCE-and DSC-MRI parameters. Results: For patients with histologically confirmed nodal metastasis, the primary tumor demonstrated a significantly lower K trans and peak change in R Ã 2 , R Ã 2 -peak enh , than patients without nodal metastasis, showing a P-value of 0.010 and 0.005 for reader 1, and 0.043 and 0.019 for reader 2, respectively. Conclusion: This study shows the feasibility of acquiring DCE-and DSC-MRI in rectal cancer by dynamic multi-echo MRI. A significant association was found between both K trans and R Ã 2 -peak enh in the primary tumor and histological nodal status of the surgical specimen, which may improve stratification of patients to intensified multimodal treatment.

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A model of the dual effect of gadopentetate dimeglumine on dynamic brain MR images

Cited by 44 publications

References 34 publications

Estimate of vascular permeability and cerebral blood volume using Gd‐DTPA contrast enhancement and dynamic T2*‐weighted MRI

Estimate of vascular permeability and cerebral blood volume using Gd‐DTPA contrast enhancement and dynamic T2*‐weighted MRI

Dual-contrast echo planar imaging with keyhole: application to dynamic contrast-enhanced perfusion studies

Dynamic multi-echo DCE- and DSC-MRI in rectal cancer: Low primary tumor K^trans and ΔR2* peak are significantly associated with lymph node metastasis

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A model of the dual effect of gadopentetate dimeglumine on dynamic brain MR images

Cited by 44 publications

References 34 publications

Estimate of vascular permeability and cerebral blood volume using Gd‐DTPA contrast enhancement and dynamic T2*‐weighted MRI

Estimate of vascular permeability and cerebral blood volume using Gd‐DTPA contrast enhancement and dynamic T2*‐weighted MRI

Dual-contrast echo planar imaging with keyhole: application to dynamic contrast-enhanced perfusion studies

Dynamic multi-echo DCE- and DSC-MRI in rectal cancer: Low primary tumor Ktrans and ΔR2* peak are significantly associated with lymph node metastasis

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Dynamic multi-echo DCE- and DSC-MRI in rectal cancer: Low primary tumor K^trans and ΔR2* peak are significantly associated with lymph node metastasis