A multilayer braided scaffold for Anterior Cruciate Ligament: Mechanical modeling at the fiber scale

Laurent, Cédric; Durville, Damien; Mainard, Didier; Ganghoffer, Jean‐François; Rahouadj, Rachid

doi:10.1016/j.jmbbm.2012.03.005

Cited by 63 publications

(53 citation statements)

References 47 publications

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“…Varying the ratios of PCL and PGA-PCL-PGA copolymer can control hydrophilicity, mechanical strength, and degradation rate properties. A finite element analysis was described to analyze the optimal configuration for a braided copoly (lactic acid-co-(E-caprolactone)) (PLCL) scaffold [24].…”

Section: Biomaterials Scaffoldsmentioning

confidence: 99%

Updates in biological therapies for knee injuries: anterior cruciate ligament

Franciozi

Ingham

Gracitelli

et al. 2014

Curr Rev Musculoskelet Med

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There have been many advances in anterior cruciate ligament reconstruction (ACLR) techniques incorporating biological treatment. The aim of this review is to discuss the recent contributions that may enlighten our understanding of biological therapies for anterior cruciate ligament (ACL) injuries and improve management decisions involving these enhancement options. Three main biological procedures will be analyzed: bio-enhanced ACL repair, bio-enhanced ACLR scrutinized under the four basic principles of tissue engineering (scaffolds, cell sources, growth factors/cytokines including platelet-rich plasma, and mechanical stimuli), and remnant-preserving ACLR. There is controversial information regarding remnant-preserving ACLR, since different procedures are grouped under the same designation. A new definition for remnant-preserving ACLR surgery is proposed, dividing it into its three major procedures (selective bundle augmentation, augmentation, and nonfunctional remnant preservation); also, an ACL lesion pattern classification and a treatment algorithm, which will hopefully standardize these terms and procedures for future studies, are presented.

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Section: Biomaterials Scaffoldsmentioning

confidence: 99%

Updates in biological therapies for knee injuries: anterior cruciate ligament

Franciozi

Ingham

Gracitelli

et al. 2014

Curr Rev Musculoskelet Med

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“…Laurent and colleagues [157] used virtual testing in the mechanical modelling of tissue engineering scaffolds of anterior cruciate ligament (ACL). The authors treated the ACL scaffold as a multi-layered braided structure with explicit modelling of the constituent fibres that make up the structure, as shown in Figure 29.…”

Section: Collagens Ligaments and Tendonsmentioning

confidence: 99%

“…Fibre Diameter, D Figure 29: Architecture of an Anterior Cruciate Ligament multi-layer braided scaffold [157].…”

Section: Layersmentioning

confidence: 99%

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Virtual testing of advanced composites, cellular materials and biomaterials: A review

Okereke

Akpoyomare

Bingley

2014

Composites Part B: Engineering

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Please cite this article as: Okereke, M.I., Akpoyomare, A.I., Bingley, M.S., Virtual testing of advanced composites, cellular materials and biomaterials: a review, Composites: Part B (2014), doi: http://dx.doi.org/10. 1016/ j.compositesb.2014.01.007 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. AbstractThis paper documents the emergence of virtual testing frameworks for prediction of the constitutive responses of engineering materials. A detailed study is presented, of the philosophy underpinning virtual testing schemes: highlighting the structure, challenges and opportunities posed by a virtual testing strategy compared with traditional laboratory experiments. The virtual testing process has been discussed from atomistic to macrostructural lengthscales of analyses. Several implementations of virtual testing frameworks for diverse categories of materials are also presented, with particular emphasis on composites, cellular materials and biomaterials (collectively described as heterogeneous systems, in this context). The robustness of virtual frameworks for prediction of the constitutive behaviour of these materials is discussed. The paper also considers the current thinking on developing virtual laboratories in relation to availability of computational resources as well as the development of multi-scale material model algorithms. In conclusion, the paper highlights the challenges facing developments of future virtual testing frameworks. This review represents a comprehensive documentation of the state of knowledge on virtual testing from microscale to macroscale length scales for heterogeneous materials across constitutive responses from elastic to damage regimes.

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“…Some future enhancements will be envisaged starting from the present study. Firstly, numerical studies that we recently reported on the braided scaffold [26,27] will be used to determine the best-suited design for the specific application that we target here. We have indeed observed that, for instance, the pore size distribution of the scaffolds used in the present study may not perfectly prevent the obstruction of external pores after 28 days.…”

Section: Preliminary Dynamic Culture In the Bioreactormentioning

confidence: 99%

Towards a Tissue-Engineered Ligament: Design and Preliminary Evaluation of a Dedicated Multi-Chamber Tension-Torsion Bioreactor

et al. 2014

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Tissue engineering may constitute a promising alternative to current strategies in ligament repair, providing that suitable scaffolds and culture conditions are proposed. The objective of the present contribution is to present the design and instrumentation of a novel OPEN ACCESSProcesses 2014, 2 168 multi-chamber tension-torsion bioreactor dedicated to ligament tissue engineering. A preliminary biological evaluation of a new braided scaffold within this bioreactor under dynamic loading is reported, starting with the development of a dedicated seeding protocol validated from static cultures. The results of these preliminary biological characterizations confirm that the present combination of scaffold, seeding protocol and bioreactor may enable us to head towards a suitable ligament tissue-engineered construct.

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A multilayer braided scaffold for Anterior Cruciate Ligament: Mechanical modeling at the fiber scale

Cited by 63 publications

References 47 publications

Updates in biological therapies for knee injuries: anterior cruciate ligament

Updates in biological therapies for knee injuries: anterior cruciate ligament

Virtual testing of advanced composites, cellular materials and biomaterials: A review

Towards a Tissue-Engineered Ligament: Design and Preliminary Evaluation of a Dedicated Multi-Chamber Tension-Torsion Bioreactor

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