1993
DOI: 10.1016/s1063-4584(05)80022-6
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A new approach to the treatment of osteoarthritis: viscosupplementation

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Cited by 58 publications
(20 citation statements)
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“…It is synthesised and secreted to joints by synoviocyte and synovial fibroblasts (Watterson and Esdaile, 2000;Kirwan, 2001). In accordance with previous studies (Endre and Janet, 1993;Peyron, 1993;Scale et al, 1994;Yoshioka et al, 1997;Shimizu et al, 1998;Dougados, 2000), it was observed that HA injections are generally well-tolerated and that they apparently aid recovery from pain and restoration of function.…”
Section: Discussionsupporting
confidence: 90%
See 1 more Smart Citation
“…It is synthesised and secreted to joints by synoviocyte and synovial fibroblasts (Watterson and Esdaile, 2000;Kirwan, 2001). In accordance with previous studies (Endre and Janet, 1993;Peyron, 1993;Scale et al, 1994;Yoshioka et al, 1997;Shimizu et al, 1998;Dougados, 2000), it was observed that HA injections are generally well-tolerated and that they apparently aid recovery from pain and restoration of function.…”
Section: Discussionsupporting
confidence: 90%
“…The preservation of cartilage is therefore extremely important. The main function of hyaluronic acid is to ensure elasticity and viscosity of leg joints (Endre and Janet, 1993;Peyron, 1993;Scale et al, 1994;Frizziero et al, 1998;Kirwan, 2001). These effects were assessed according to the amount of stress applied to the legs.…”
Section: Discussionmentioning
confidence: 99%
“…In the synovial fluid, HA acts as a lubricant and a shock absorber. Due to the meshwork it forms in aqueous solutions [24], it acts as a semi-permeable barrier regulating metabolic exchanges between the cartilage and the synovial fluid, as a cell traffic controlling agent and as a viscoelastic shield around synoviocytes and adjacent nerve endings shielding the latter from nociceptive substances [23]. Through its molecular sieve effect, HA hinders the free movement of lytic enzymes, inflamma- tion mediators and inflammatory cells in the synovial fluid [22].…”
Section: Discussionmentioning
confidence: 99%
“…With the unique physico-chemical and biological properties, such as high water-holding capacity, viscoelasticity and biocompatibility, HA finds wide applications in biomedical, food, healthcare and cosmetic fields [2][3][4][5][6].…”
Section: Introductionmentioning
confidence: 99%