2020
DOI: 10.1038/s41421-019-0140-8
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A new class of broadly neutralizing antibodies that target the glycan loop of Zika virus envelope protein

Abstract: Zika virus (ZIKV) infection poses a serious threat to human health. However, no licensed vaccine or therapeutic drug is currently available for ZIKV. We have previously shown that recombinant ZIKV E80 protein induced potent neutralizing antibody response and protected mice from lethal viral challenge. In the present study, we isolated five ZIKV neutralizing monoclonal antibodies (mAbs) from E80-immunized mice. These five mAbs specifically bound and neutralized Asian-lineage ZIKV strains. Epitope mapping reveal… Show more

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Cited by 23 publications
(23 citation statements)
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“…Anti-RBD polyclonal antibody and monoclonal antibody (MAb) 1A10 were prepared by immunizing BALB/c mice with recombinant SARS-CoV-2 RBD fused with a C-terminal mouse IgGFc tag (Sino Biological Inc., Beijing, China) using previously described protocols ( 63 ).…”
Section: Methodsmentioning
confidence: 99%
See 1 more Smart Citation
“…Anti-RBD polyclonal antibody and monoclonal antibody (MAb) 1A10 were prepared by immunizing BALB/c mice with recombinant SARS-CoV-2 RBD fused with a C-terminal mouse IgGFc tag (Sino Biological Inc., Beijing, China) using previously described protocols ( 63 ).…”
Section: Methodsmentioning
confidence: 99%
“…We used UCSF Chimera and ChimeraX for figure generation (59,61), and also for rotation, translation, RMSD, and vdw contact measurement. Interaction surface analysis was conducted by PISA server (62). Fig.…”
Section: Pseudo Atomic Model Buildingmentioning
confidence: 99%
“…Anti-RBD polyclonal antibody and monoclonal antibody (MAb) 1A10 were prepared by immunizing BALB/c mice with recombinant SARS-CoV-2 RBD fused with a C-terminal mouse IgGFc tag (Sino Biological Inc, Beijing, China) using previously described protocols (Qu et al, 2020).…”
Section: Elisamentioning
confidence: 99%
“…MAb 9B5 is an antibody against CVA16 41 . MAb 1C11 is an IgG2a antibody against zika virus (ZIKV) E protein 42 and MAb 1F4 is an IgG2b antibody against hepatitis C virus (HCV) E2 protein, serving as isotype controls in this study.…”
Section: Cells and Virusesmentioning
confidence: 99%