A new phenolic glycoside and two new monoterpenoid furocoumarins from Aurantii Fructus Immaturus

Xiong, Ying; Chang, Meiyan; Deng, Ke-Zhong; Luo, Yongming

doi:10.1080/14786419.2015.1118634

Cited by 10 publications

(8 citation statements)

References 4 publications

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“…In general, polar solvents, such as water (H 2 O), methanol (MeOH), ethanol (EtOH), acetone, and their aqueous mixtures, are the most widely used as extraction solvents [47,49,50,51,52,53,54,55,57,58,60,61,62,63,64,65,66,67,68,69,70,71,72,73]. The use of EtOAc, chloroform, dichloromethane, and petroleum ether has also been described in the literature [56,59,61,67,74,75,76,77,78].…”

Section: Extraction Of Furanocoumarins From Plantsmentioning

confidence: 99%

“…If the final purpose is the isolation of furocoumarins from the plant material for the evaluation of their biological activity, the raw extract obtained has been usually submitted to further purification steps [52,65,66,69,70,71,72,74,91]. In this case, Soxhlet extraction and heat reflux extraction (HRE) have been widely applied with both polar and non-polar solvents [71,72,74,75,77].…”

Section: Extraction Of Furanocoumarins From Plantsmentioning

confidence: 99%

“…In this case, Soxhlet extraction and heat reflux extraction (HRE) have been widely applied with both polar and non-polar solvents [71,72,74,75,77]. After the extraction, furanocoumarins have been frequently isolated from the raw extracts by means of sequential silica gel column chromatography, eluted under normal phase conditions [66,69,70,71,72,75,76,77,78,79]. It is worth noting that preparative counter current chromatography has also been applied to achieve the final purification of furanocoumarins from Angelica dahurica and Toddalia asiatica (L.) Lam.…”

Section: Extraction Of Furanocoumarins From Plantsmentioning

confidence: 99%

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Botanical Sources, Chemistry, Analysis, and Biological Activity of Furanocoumarins of Pharmaceutical Interest

et al. 2019

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The aim of this work is to provide a critical review of plant furanocoumarins from different points of view, including their chemistry and biosynthetic pathways to their extraction, analysis, and synthesis, to the main biological activities found for these active compounds, in order to highlight their potential within pharmaceutical science. The limits and the possible improvements needed for research involving these molecules are also highlighted and discussed.

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Section: Extraction Of Furanocoumarins From Plantsmentioning

confidence: 99%

Section: Extraction Of Furanocoumarins From Plantsmentioning

confidence: 99%

Section: Extraction Of Furanocoumarins From Plantsmentioning

confidence: 99%

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Botanical Sources, Chemistry, Analysis, and Biological Activity of Furanocoumarins of Pharmaceutical Interest

et al. 2019

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“…In previous reports, components in AF were authenticated and quantified using HPLC-diode array detection (DAD) [14], LC-MS [15], GC-MS [16], and NMR [17]. Recently, highresolution mass spectrometry, including TOF-MS [13] and ion trap MS [18], has been applied to identify chemical compositions in AF.…”

Section: Introductionmentioning

confidence: 99%

Quantitative analysis of multicomponents by single marker combined with HPLC fingerprint qualitative analyses for comprehensive evaluation of Aurantii Fructus

Lei

Wang

Sun³

et al. 2020

J of Separation Science

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The present study aimed to develop a strategy involving quantitative analysis of multicomponents by single marker in combination with high-performance liquid chromatography fingerprint qualitative analysis for performing the quality control of Aurantii Fructus. The content of 12 components (eriocitrin, neoeriocitrin, narirutin, naringin, hesperidin, neohesperidin, meranzin, poncirin, naringenin, nobiletin, tangeretin, and auraptene) in samples was determined using reliable relative correction factors that were obtained using naringin as an internal reference standard. The new method demonstrated good applicability, and no significant differences were observed between the external standard method and the new method as determined by calculating standard method difference. Qualitative evaluation of samples was conducted using similarity analysis, hierarchical cluster analysis, and quality fluctuation analysis. Chromatographic fingerprint data were divided into three groups by similarity and hierarchical cluster analyses, and seven components may have a more significant impact on the quality of Aurantii Fructus in quality fluctuation analysis. Overall, the study suggests that the qualitative and quantitative analyses of multicomponents using quantitative analysis of multicomponents by single marker combined with chromatographic fingerprinting can be considered good quality criteria for performing quality control and providing technical support for the further pharmacological and pharmaceutical research of Aurantii Fructus. K E Y W O R D Schromatographic fingerprints, quality control, quantitative analysis, traditional Chinese medicine Article Related Abbreviations: AF, Aurantii Fructus; DAD, diode array detection; ESM, external standard method; HCA, hierarchical cluster analysis; QAMS, quantitative analysis of multicomponents by single marker; RCF, relative correction factor; SA, similarity analysis; SMD, standard method difference; TCM, traditional Chinese medicine. 1382

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“…Even if HPLC-DAD and HPLC-MS have been utilized to quantify constituents, they can hardly be used to identify unknown compounds. Moreover, nuclear magnetic resonance (NMR) has been used to identify unknown components in AFI after separation [ 10 , 11 ]. However, to the best of our knowledge, NMR has not been applied to determine multiple constituents of AF and AFI simultaneously.…”

Section: Introductionmentioning

confidence: 99%

Identification and Comparison of Constituents of Aurantii Fructus and Aurantii Fructus Immaturus by UFLC-DAD-Triple TOF-MS/MS

et al. 2018

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Although Aurantii Fructus (AF) and Aurantii Fructus Immaturus (AFI) are both the fruits of the same rutaceae plant at different stages of growth, they exert similar yet distinct clinical effects. The chemical composition is crucial for quality control as well as therapeutic application. To address this concern, it is significant to evaluate the similarities and differences of the constituents in both AF and AFI. The extract of AF and AFI were comprehensively analyzed by ultra fast liquid chromatography-photodiode array detector-triple-time of flight-tandem mass spectrometry (UFLC-DAD-Triple TOF-MS/MS). Among the 40 compounds detected, 19 metabolites were detected in both the AF and AFI; whereas 13 compounds were only detected in AF and five constituents were exclusively detected in AFI. In particular, even in AFI, three compounds were only identified in AFI (Citrus aurantium’ L. and its cultivar). Among the 18 compounds confirmed by standard database, 13 compounds were reported in AF and AFI for the first time. Furthermore, the distinction was also revealed by the content of naringin, hesperidin, neohesperidin, and synephrine. The study directly contributed to the similarities and differences of AF and AFI. Herein, similarities and the differences in chemical profiles of AF and AFI could explain the current clinical applications.

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A new phenolic glycoside and two new monoterpenoid furocoumarins from Aurantii Fructus Immaturus

Cited by 10 publications

References 4 publications

Botanical Sources, Chemistry, Analysis, and Biological Activity of Furanocoumarins of Pharmaceutical Interest

Botanical Sources, Chemistry, Analysis, and Biological Activity of Furanocoumarins of Pharmaceutical Interest

Quantitative analysis of multicomponents by single marker combined with HPLC fingerprint qualitative analyses for comprehensive evaluation of Aurantii Fructus

Identification and Comparison of Constituents of Aurantii Fructus and Aurantii Fructus Immaturus by UFLC-DAD-Triple TOF-MS/MS

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