A New Potential Weapon for Fighting Obesity: <i>Forskolin—the Active Diterpene in Coleus</i>

Lieberman, Shari

doi:10.1089/act.2004.10.330

Cited by 8 publications

(3 citation statements)

References 4 publications

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“…22), a diterpene, was isolated from the roots and has been well researched. 80,81 It is known to activate cyclic adenosine monophosphate (cAMP) by acting directly on the enzyme adenylate cyclase. 82 Activation of cAMP promotes the breakdown of stored fat, increases the basal metabolic rate, increases utilization of body fat, and regulates the thermogenic response to food.…”

Section: Camellia Sinensis (Tea)mentioning

confidence: 99%

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Natural products in anti-obesity therapy

2011

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Section: Camellia Sinensis (Tea)mentioning

confidence: 99%

“…84 With the exception of an increase in HDL, no significant effects were recorded for extensive blood and marker screening, the oral lethal dose (LD 50 ) of forskolin was 3100 mg kg À1 , and no mutagenicity was observed. 80,81 3.13 Curcuma longa (Turmeric)…”

Section: Camellia Sinensis (Tea)mentioning

confidence: 99%

Natural products in anti-obesity therapy

2011

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“…In another study, 250 mg forskolin was given twice a day to six overweight healthy women. The mean values for body weight and fat content were signifi cantly decreased and lean body mass was signifi cantly increased after 4 and 8 weeks (Lieberman 2004). On the other hand, Henderson et al (2005) reported that forskolin supplementation did not promote weight loss, but may have helped mitigate weight gain in overweight females.…”

Section: Referencesmentioning

confidence: 95%

The effects of forskolin and rolipram on cAMP, cGMP and free fatty acid levels in diet induced obesity

Döşeyici

Mehmetoğlu

Toker

et al. 2014

Biotechnic & Histochemistry

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Obesity is a major health problem. We investigated the effects of forskolin and rolipram in the diet of animals in which obesity had been induced. We used 50 female albino Wistar rats that were assigned randomly into five groups as follows: group 1, control; group 2, high fat diet; group 3, high fat diet + forskolin; group 4, high fat diet + rolipram; and group 5, high fat diet + rolipram + forskolin. The rats were fed for 10 weeks and rolipram and forskolin were administered during last two weeks. The animals were sacrificed and blood samples were obtained. Serum cAMP, cGMP and free fatty acids (FFA) levels were measured using ELISA assays. We also measured weight gain during the 10 week period. cAMP and FFA levels of groups 3, 4 and 5 were significantly higher than those of groups 1 and 2. We found no significant differences in serum cGMP levels among the groups. The weight gain in groups 3, 4 and 5 was significantly less than for group 2. We also found that the weight gain in group 5 was significantly less than in groups 3 and 4. We found that both forskolin and rolipram stimulated lipolysis and inhibited body weight increase by increasing cAMP levels. Also, combination therapy using the two agents may be more effective in preventing diet induced obesity than either agent alone. We found also that these agents did not effect cellular cGMP levels in diet induced obesity.

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