A nomogram to predict lymph node metastasis in patients with early gastric cancer

Guo, Chun Guang; Zhao, Dong; Liu, Qian; Zhou, Zhibo; Zhao, Ping; Wang, Gui Qi; Cai, Jian

doi:10.18632/oncotarget.14660

Cited by 28 publications

(15 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Lager tumor size, depressed type, and poor differentiation were proved to be independent risk factors in the present study which coincides with previous studies [19][20][21]. Lager tumor size, depressed type, and poor differentiation indicated worse biological behavior, which might also indicate higher probability of LNM.…”

Section: Discussionsupporting

confidence: 92%

Development and validation of a nomogram for preoperative prediction of lymph node metastasis in early gastric cancer

et al. 2020

View full text Add to dashboard Cite

Background: The status of lymph nodes in early gastric cancer is critical to make further clinical treatment decision, but the prediction of lymph node metastasis remains difficult before operation. This study aimed to develop a nomogram that contained preoperative factors to predict lymph node metastasis in early gastric cancer patients. Methods: This study analyzed the clinicopathologic features of 823 early gastric cancer patients who underwent gastrectomy retrospectively, among which 596 patients were recruited in the training cohort and 227 patients in the independent validation cohort. Significant risk factors in univariate analysis were further identified to be independent variables in multivariable logistic regression analysis, which were then incorporated in and presented with a nomogram. And internal and external validation curves were plotted to evaluate the discrimination of the nomogram. Results: Totally, six independent predictors, including the tumor size, macroscopic features, histology differentiation, P53, carbohydrate antigen 19-9, and computed tomography-reported lymph node status, were enrolled in the nomogram. Both the internal validation in the training cohort and the external validation in the validation cohort showed the nomogram had good discriminations, with a C-index of 0.82 (95%CI, 0.78 to 0.86) and 0.77 (95%CI, 0.60 to 0.94) respectively. Conclusions: Our study developed a new nomogram which contained the most common and significant preoperative risk factors for lymph node metastasis in patients with early gastric cancer. The nomogram can identify early gastric cancer patients with the high probability of lymph node metastasis and help clinicians make more appropriate decisions in clinical practice.

show abstract

Section: Discussionsupporting

confidence: 92%

Development and validation of a nomogram for preoperative prediction of lymph node metastasis in early gastric cancer

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Among all the high‐risk factors for LNM in EGC, lymphovascular invasion is the most important and has been demonstrated in almost all published studies with the highest OR of LNM, which was also confirmed in this multicenter study. This fact has been used as a contraindication of endoscopic therapy for EGC in both Japanese and Chinese clinical practice guidelines on EGC therapy .…”

Section: Discussionsupporting

confidence: 86%

Risk factors of lymph node metastasis in 1620 early gastric carcinoma radical resections in Jiangsu Province in China: A multicenter clinicopathological study

Chen

Wang

Cheng³

et al. 2017

J of Digest Diseases

View full text Add to dashboard Cite

show abstract

“…Nomograms have been widely used for quantifying the risk factors of various diseases [ 32 , 33 ]. The effects of several separate variables are integrated by a nomogram to give an individualized risk assessment for each patient.…”

Section: Discussionmentioning

confidence: 99%

The diagnostic value of white blood cell, neutrophil, neutrophil-to-lymphocyte ratio, and lymphocyte-to-monocyte ratio in patients with primary angle closure glaucoma

Cao

Han

et al. 2017

Oncotarget

View full text Add to dashboard Cite

ObjectiveInflammatory mechanisms may have a role in the pathogenesis of primary angle closure glaucoma (PACG). The objective of this study was to investigate the diagnostic value of white blood cell (WBC), neutrophil, neutrophil to lymphocyte ratio (NLR), and lymphocyte to monocyte ratio (LMR) in patients with PACG and its association with glaucoma severity.MethodThe study was retrospectively assessed in 771 consecutive PACG patients and 770 control subjects, laboratory parameters and clinical parameters were obtained from a medical data platform. Patients were divided into three groups with different severity based on perimetry, i.e. mild (mean deviation (MD) ≤6.00 dB), moderate (12 dB≥ MD>6 dB) and severe (MD>12 dB). We developed a nomogram to specifically identify individual patient’s risk.ResultsThe mean levels of neutrophil, NLR and WBC was higher in PACG than control group, and lowest in the mild PACG group, followed by moderate PACG and severe PACG (p<0.05). The AUROC value of NLR and LMR was found to be 0.719, 0.699, respectively. Multiple linear regressions showed that there was a significant correlation between WBC and MD (B=0.151, p<0.001), neutrophil and MD (B=0.143, p=0.003), NLR and MD (B=0.144, p=0.001), LMR and MD (B=-0.100, p=0.034). Logistic regression analyses revealed that WBC (OR=1.208, 95%CI=1.179-1.238), neutrophil (OR=1.598, 95%CI=1.541-1.656), NLR (OR=2.313, 95%CI=2.200-2.431), and LMR (OR=0.682, 95%CI=0.666-0.699) were associated with PACG.ConclusionOur study suggested that WBC, neutrophil, NLR, and LMR was related with PACG, and NLR and LMR may be useful as biomarkers.

show abstract

A nomogram to predict lymph node metastasis in patients with early gastric cancer

Cited by 28 publications

References 31 publications

Development and validation of a nomogram for preoperative prediction of lymph node metastasis in early gastric cancer

Development and validation of a nomogram for preoperative prediction of lymph node metastasis in early gastric cancer

Risk factors of lymph node metastasis in 1620 early gastric carcinoma radical resections in Jiangsu Province in China: A multicenter clinicopathological study

The diagnostic value of white blood cell, neutrophil, neutrophil-to-lymphocyte ratio, and lymphocyte-to-monocyte ratio in patients with primary angle closure glaucoma

Contact Info

Product

Resources

About