A novel electrochemical aptasensor based on Ti3C2-MOFs nanocomposites for rapid streptomycin detection in milk samples

Peng, Haishuai; Hui, Yuanyuan; Zhang, Lei; Zhang, Fuxin; Liu, Yufang; Zheng, Jianbin; Jia, Rong; Song, Yuxuan; Wang, Bini

doi:10.1016/j.snb.2022.132119

Cited by 24 publications

(3 citation statements)

References 44 publications

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“…Then, the DPV or ECL signal was measured using VMSF/ITO electrode. For real sample analysis, milk and egg white were centrifuged at 10,000 rpm for 10 min to remove the interfering substances such as fat and protein ( 37 ). Due to the excellent anti-fouling and anti-interference performance of VMSF, no additional filtering step was required.…”

Section: Methodsmentioning

confidence: 99%

Novel electrochemical and electrochemiluminescence dual-modality sensing platform for sensitive determination of antimicrobial peptides based on probe encapsulated liposome and nanochannel array electrode

2022

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With the increasing application of antimicrobial peptides (AMPs) to replace antibiotics in medicine, food and agriculture, it is highly desired to develop a fast, reliable, and convenient strategy for sensitive detection of AMPs. Herein, a novel electrochemical (EC) and electrochemiluminescence (ECL) dual-modality sensing platform was developed based on probe encapsulated liposomes and nanochannel array modified electrodes, which enables sensitive determination of nisin in food samples. The bifunctional probe with both EC and ECL signals, tris(2,2-bipyridyl) dichlororuthenium (II) (Ru(bpy)32+), was chosen to be easily encapsulated in liposomes (Ru(bpy)32+@liposome). Based on the unique sterilization mechanism that AMPs can disrupt cell membranes, Ru(bpy)32+@liposome can be destroyed by nisin and release a large number of Ru(bpy)32+ probes. Vertically-ordered mesoporous silica-nanochannel film (VMSF) modified ITO electrodes (VMSF/ITO) prepared by electrochemically assisted self-assembly (EASA) method were applied as the sensing electrode. Due to the efficient enrichment of Ru(bpy)32+ by the negatively charged nanochannel arrays, VMSF/ITO enables detection of the EC/ECL signals of the released Ru(bpy)32+ probes with ultrahigh sensitivity. In consequence, sensitive dual-modality detection of nisin was achieved by the combination of Ru(bpy)32+@liposome and VMSF/ITO. The developed sensing system can realize sensitive determination of nisin in ECL mode in the concentration range of 10 ng/ml to 50 μg/ml with a limit of detection (LOD) of 9.3 ng/ml, or in EC mode from 800 ng/ml to 100 μg/ml with a LOD of 70 ng/ml. Combined with the excellent anti-fouling and anti-interference performance of VMSF, rapid and sensitive detection of nisin in milk or egg white was also achieved by the sensor.

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Section: Methodsmentioning

confidence: 99%

Novel electrochemical and electrochemiluminescence dual-modality sensing platform for sensitive determination of antimicrobial peptides based on probe encapsulated liposome and nanochannel array electrode

2022

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“…15B). 174 To be specific, nanocomposites with excellent electrochemical properties were immobilized on the electrode and modified with the complementary sequence of STR aptamer. Then, the STR aptamer labeled with methylene blue was assembled with nanocomposites as the reporter.…”

Section: Biomedical Applications Of Mof Nanocompositesmentioning

confidence: 99%

Surface ligand-assisted synthesis and biomedical applications of metal–organic framework nanocomposites

Wang

et al. 2023

Nanoscale

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“…This “on-off-on” aptasensing scheme was able to measure STR concentration in honey in the range of 1 to 1000 nM. In another electrochemical aptasensor, polyethyleneimine (PEI) was used in a metal–organic framework (PEI-UIO-66-NH 3 ) to coat the polyaniline-Ti 3 C 2 MXene surface (PANI-MXene), which was used to modify a glassy electrode ( Figure 8 (Aa)) [ 103 ]. After incubating with cDNA, the electrode was ready to immobilize the STR aptamer-methylene blue (MB) structure, which is released from the electrode in the presence of STR.…”

Section: Application Of Mxene-based Na Biosensors In the Agricultural...mentioning

confidence: 99%

MXene-Based Nucleic Acid Biosensors for Agricultural and Food Systems

Wang

Gunasekaran

2022

Biosensors

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MXene is a two-dimensional (2D) nanomaterial that exhibits several superior properties suitable for fabricating biosensors. Likewise, the nucleic acid (NA) in oligomerization forms possesses highly specific biorecognition ability and other features amenable to biosensing. Hence the combined use of MXene and NA is becoming increasingly common in biosensor design and development. In this review, MXene- and NA-based biosensors are discussed in terms of their sensing mechanisms and fabrication details. MXenes are introduced from their definition and synthesis process to their characterization followed by their use in NA-mediated biosensor fabrication. The emphasis is placed on the detection of various targets relevant to agricultural and food systems, including microbial pathogens, chemical toxicants, heavy metals, organic pollutants, etc. Finally, current challenges and future perspectives are presented with an eye toward the development of advanced biosensors with improved detection performance.

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A novel electrochemical aptasensor based on Ti3C2-MOFs nanocomposites for rapid streptomycin detection in milk samples

Cited by 24 publications

References 44 publications

Novel electrochemical and electrochemiluminescence dual-modality sensing platform for sensitive determination of antimicrobial peptides based on probe encapsulated liposome and nanochannel array electrode

Novel electrochemical and electrochemiluminescence dual-modality sensing platform for sensitive determination of antimicrobial peptides based on probe encapsulated liposome and nanochannel array electrode

Surface ligand-assisted synthesis and biomedical applications of metal–organic framework nanocomposites

MXene-Based Nucleic Acid Biosensors for Agricultural and Food Systems

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