A novel extract from bovine colostrum whey supports anti-bacterial and anti-viral innate immune functions in vitro and in vivo

Benson, Kathleen F.; Carter, Steve G.; Patterson, Kelly M.; Patel, Dilip; Jensen, Gitte S.

doi:10.1016/j.ypmed.2011.12.023

Cited by 30 publications

(23 citation statements)

References 40 publications

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“…Although further investigations into the role of cytokines or proposed bioactive peptides are required, the findings here suggest that consumption of COL does increase the bioavailability of components, which enhance receptor-mediated neutrophil oxidative activity (e.g., fMLP). Jensen et al (2012) observed an increase in phagocytic activity from baseline in human polymorphonuclear cells obtained at 1 and 2 h following consumption of a low-molecular-weight fraction of COL. It is currently unclear how long any priming effect of COL may last but it has previously been reported that enhanced oxidative burst responses to fMLP can last ≥24 h following exposure to priming agents (e.g., granulocyte colony-stimulating factor; Ichinose et al, 1990).…”

Section: Discussionmentioning

confidence: 80%

“…The findings of in vitro culture demonstrate that COL possesses the ability to prime neutrophil function (Sugisawa et al, 2001(Sugisawa et al, , 2003Benson et al, 2012). Neutrophils can be primed by a range of cytokines (granulocyte macrophage colony-stimulating factor, granulocyte colony-stimulating factor, interleukin-8, tumor necrosis factor α), which amplify responses to subsequent stimulation (Elbim et al, 1994).…”

Section: Discussionmentioning

confidence: 99%

“…Animal and in vitro culture studies provide evidence of direct effects of COL on phagocytosis and oxidative burst of polymorphonuclear cells (i.e., neutrophils; Sugisawa et al, 2001Sugisawa et al, , 2003Benson et al, 2012). Neutrophils form a critical part of the human body's first line of defense as the most abundant leukocyte in the circulation.…”

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confidence: 99%

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Influence of 4 weeks of bovine colostrum supplementation on neutrophil and mucosal immune responses to prolonged cycling

Jones

Thatcher

March

et al. 2015

Scandinavian Med Sci Sports

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13Bovine colostrum (COL) has been advocated as a nutritional countermeasure to 14 exercise-induced immune dysfunction. The aims of this study were to identify the 15 effects of 4 weeks of COL supplementation on neutrophil responses and mucosal 16 immunity following prolonged exercise. In a randomised double-blind, parallel group 17 design, participants (age 28 ± 8 years; body mass [BM] 79 ± 7 kg; height 182 ± 6 cm; 18 maximal oxygen uptake [ ! VO 2 max] 55 ± 9 mL·kg-1 ·min -1 ) were assigned to 20 g per 19 day of COL (n = 10) or an isoenergetic/isomacronutrient placebo (PLA) (n = 10) for 4 20 weeks. Venous blood and unstimulated saliva samples were obtained before and 21 after 2.5 h of cycling at 15% Δ (~ 55-60% ! VO 2 max). A significantly greater fMLP-22 stimulated oxidative burst was observed in the COL group compared with PLA group 23 (p < 0.05) and a trend toward a time × group interaction (p = 0.06). However, there 24 was no effect of COL on leukocyte trafficking, PMA-stimulated oxidative burst, 25 bacterial-stimulated neutrophil degranulation, salivary secretory IgA, lactoferrin or 26 lysozyme (p > 0.05). These findings provide further evidence of the beneficial effects 27 of COL on receptor-mediated stimulation of neutrophil oxidative burst in a model of 28 exercise-induced immune dysfunction. 29

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Section: Discussionmentioning

confidence: 80%

Section: Discussionmentioning

confidence: 99%

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Influence of 4 weeks of bovine colostrum supplementation on neutrophil and mucosal immune responses to prolonged cycling

Jones

Thatcher

March

et al. 2015

Scandinavian Med Sci Sports

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“…In vitro studies in which colostrum or isolated fractions thereof are added to incubation media generally show an enhancement or priming of ex vivo immune cell functions. This includes stimulated neutrophil oxidative burst and degranulation functions 136,137 , and neutrophil and peripheral blood mononuclear cell cytokine production. 138,139 It has been suggested that such effects are attributable to the lowest molecular weight (MW) fractions (< 10 kDa).…”

Section: Dairy-derived Supplements or Functional Foods (Probiotics Bmentioning

confidence: 99%

Nutritional and Physical Activity Interventions to Improve Immunity

Davison

Kehaya

Jones

2014

American Journal of Lifestyle Medicine

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Physical activity and nutrition are important in a healthy lifestyle with potential benefits to immunity often overlooked. Infection of the upper respiratory tract, and the associated symptoms, are the most frequent presentations to general practitioners and may have significant economic and social impact. In this review, we consider the role of physical activity and nutrition in improving immunity. Evidence suggests that regular moderate activity is particularly beneficial for immune enhancement and reducing the risk of infection. We also discuss some nutritional strategies. Unfortunately, the evidence for many is weak. Avoiding nutritional deficiencies seems the most pragmatic recommendation. This can be achieved with a balanced diet. Including a variety of fruits and vegetables may help ensure adequate intake of essential nutrients with little risk of excess intake of any single nutrient. Supplementation with individual nutrients is generally not recommended. Multinutrients may be beneficial for those with a preexisting deficiency but not if normal dietary intake is sufficient. Further benefit may be gained from some supplements including probiotics, bovine colostrum, and some plant-derived products (Echinacea, black elderberry, and some polyphenols) but only in specific situations/contexts. Individuals should consider their personal needs, use caution, and avoid the indiscriminate use of supplements.

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“…Although the effect of colostrum is species-specific, a growing body of literature has documented the protective effect of BC against several viral infections in humans (Bojsen et al, 2007;Ng et al, 2010;Benson et al, 2012;Inagaki et al, 2014;El-Fakharany et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

Colostrum from cows immunized with a veterinary vaccine against bovine rotavirus displays enhanced in vitro anti-human rotavirus activity

Civra

Altomare

Francese

et al. 2019

Journal of Dairy Science

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Human rotaviruses represent a major cause of severe diarrheal disease in infants and young children. The limited impact of oral vaccines on global estimates of rotavirus mortality and the suboptimal use of oral rehydration justify the need for alternative prophylactic and therapeutic strategies, especially for immunocompromised hosts. The protective effects of colostrum-the first milk produced during the initial 24 to 48 h after parturition-are well documented in the literature. In particular, the ingestion of hyperimmune bovine colostrum has been proposed as an alternative preventive approach against human rotavirus gastroenteritis. Although the immunization of pregnant cows with human rotavirus boosts the release of specific immunoglobulin G in bovine colostrum, it raises regulatory and safety issues. In this study, we demonstrated that the conventional bovine rotavirus vaccine is sufficient to enhance the anti-human rotavirus protective efficacy of bovine colostrum, thus providing a conservative approach to produce hyperimmune bovine colostrum, making it exploitable as a functional food.

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A novel extract from bovine colostrum whey supports anti-bacterial and anti-viral innate immune functions in vitro and in vivo

Cited by 30 publications

References 40 publications

Influence of 4 weeks of bovine colostrum supplementation on neutrophil and mucosal immune responses to prolonged cycling

Influence of 4 weeks of bovine colostrum supplementation on neutrophil and mucosal immune responses to prolonged cycling

Nutritional and Physical Activity Interventions to Improve Immunity

Colostrum from cows immunized with a veterinary vaccine against bovine rotavirus displays enhanced in vitro anti-human rotavirus activity

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