A novel formulation of Folic acid gel in the treatment of Desquamative Gingivitis

Khan, Saif; Rahman, Syed Ziaur

doi:10.3329/bjms.v19i2.44993

Cited by 5 publications

(10 citation statements)

References 7 publications

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“…117,118 Hence, a multitude of ailments have been linked to FA deficiency, including heart diseases, neural tube defects, higher tendency to mutagenesis, and poor wound healing. 117,119,120 Dietary FA could be damaged during food processing and cooking, and it is partially compensated for by FA synthesized by the gut microflora. 117,119,120 the oral mucosa to infection, ulceration, gingivitis, periodontitis, and poor wound healing outcomes.…”

Section: Ta B L Ementioning

confidence: 99%

Can vitamins improve periodontal wound healing/regeneration?

Fawzy El‐Sayed,

Cosgarea,

Sculean

et al. 2023

Periodontology 2000

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Periodontitis is a complex inflammatory disorder of the tooth supporting structures, associated with microbial dysbiosis, and linked to a number if systemic conditions. Untreated it can result in an irreversible damage to the periodontal structures and eventually teeth loss. Regeneration of the lost periodontium requires an orchestration of a number of biological events on cellular and molecular level. In this context, a set of vitamins have been advocated, relying their beneficial physiological effects, to endorse the biological regenerative events of the periodontium on cellular and molecular levels. The aim of the present article is to elaborate on the question whether or not vitamins improve wound healing/regeneration, summarizing the current evidence from in vitro, animal and clinical studies, thereby shedding light on the knowledge gap in this field and highlighting future research needs. Although the present review demonstrates the current heterogeneity in the available evidence and knowledge gaps, findings suggest that vitamins, especially A, B, E, and CoQ10, as well as vitamin combinations, could exert positive attributes on the periodontal outcomes in adjunct to surgical or nonsurgical periodontal therapy.

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Section: Ta B L Ementioning

confidence: 99%

Can vitamins improve periodontal wound healing/regeneration?

Fawzy El‐Sayed,

Cosgarea,

Sculean

et al. 2023

Periodontology 2000

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“…The following constituents were used in making 0.1% folic acid gel: Carbopol 934 CDH -0.5 g, polyethylene glycol 200 -15 ml, glycerine -5 ml, methyl paraben -0.18 g, propylparaben -0.02 g, aspartame -0.4 g, folic acid -0.1 g and distilled water -78.8 ml. [10] The above constituents were mixed gently by adding them in a glass jar gently stirring on a magnetic stirrer until a gel form appeared. The gel thus formed was stored in plastic bottles in a refrigerator at −5°C at the Department of Saidla (Unani Pharmacy, Ajmal Khan Tibbiya College, Aligarh Muslim University, Aligarh) [Figure 1].…”

Section: Preparation 100 ML Of 01% Folic Acid Gelmentioning

confidence: 99%

Comparative study for safety and efficacy of a novel folic acid formulation gel with 0.1% triamcinolone acetonide paste in experimentally induced oral ulcer

Rashid¹,

Rahman

Khan

2021

IJPP

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Objectives: The objective of the present study was to evaluate the efficacy and safety of 0.1% novel folic acid gel in blunt dental instrument-induced oral ulcer in animal models (both rats and rabbits). Materials and Methods: The study was conducted in the Experimental Laboratory, Department of Pharmacology, Jawaharlal Nehru Medical College, Aligarh Muslim University. Animals were randomly divided into three interventional groups, namely Group 1 (folic acid gel), Group 2 (triamcinolone oromucosal paste) and Group 3 (control). We created a linear oral ulcer of 5 mm with the blunt dental instrument in both rats and rabbits. Each group consists of 10 animals (6 rats + 4 rabbits). Group 1 received test drug 0.1% novel folic acid gel formulated by us, Group 2 was positive control and received standard local drug 0.1% Kenacort triamcinolone oromucosal paste and Group 3 served as a negative control group where no treatment was given. Results: No untoward reaction was observed on the irritancy test. Kruskal–Wallis test applied for comparison of results. After 1 week of post-ulcer induction, there was a marked improvement in healing of oral ulcers in both Group 1 and Group 2, but more statistically significant healing was seen in Group 1 (folic acid gel). Both Groups 1 and 2 showed steady improvement in the healing of oral ulcers as compared to their pre-treated values and again were more marked in Group 1. Conclusion: Local folic acid gel supplementation was safe and had shown to augment oral ulcer healing in rats and rabbit’s animal models.

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“…Its deficiency leads to DNA damage, impaired DNA repair, abnormal DNA methylation, and increased propensity to mutagenesis, which predisposes to increased cancer risk. 1 , 2 , 3 The same can be reversed by FA supplementation, which increases apoptosis of dysplastic epithelial cells with damaged DNA, by increasing the expression of the p53 gene and decreasing the expression of the Bcl-2 gene. This process plays a vital role in host defense and the suppression of mutagenesis.…”

mentioning

confidence: 99%

“…It is an essential micronutrient involved in the one-carbon transfer or methylation reactions, purine and pyrimidine biosynthesis, and conversion of homocysteine to methionine. 1 , 2 , 3 …”

mentioning

confidence: 99%

“…We need to open new vistas in the development of local drug delivery devices for targeted FA delivery directly to the lesion site, circumventing the oral/systemic route. 3 , 6 , 8 , 9 , 10 Further, multicentric randomized controlled clinical trials are necessary to establish the adjunct use of systemic and local FA supplementation in the management of oral mucosal diseases. This will lead to the development of a novel and alternate strategy to mouthwashes and topical steroids, which are associated with various side effects like tooth discoloration, candidiasis, cytotoxicity, and poor wound healing outcomes.…”

mentioning

confidence: 99%

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