A Novel Method for Evaluating the Cardiotoxicity of Traditional Chinese Medicine Compatibility by Using Support Vector Machine Model Combined with Metabonomics

Abstract

Traditional biochemical and histopathological tests have been used to evaluate the safety of traditional Chinese medicine (TCM) compatibility for a long time. But these methods lack high sensitivity and specificity. In the previous study, we have found ten biomarkers related to cardiotoxicity and established a support vector machine (SVM) prediction model. Results showed a good sensitivity and specificity. Therefore, in this study, we used SVM model combined with metabonomics UPLC/Q-TOF-MS technology to build a rapid and sensitivity and specificity method to predict the cardiotoxicity of TCM compatibility. This study firstly applied SVM model to the prediction of cardiotoxicity in TCM compatibility containing Aconiti Lateralis Radix Praeparata and further identified whether the cardiotoxicity increased after Aconiti Lateralis Radix Praeparata combined with other TCM. This study provides a new idea for studying the evaluation of the cardiotoxicity caused by compatibility of TCM.

Fritillariae Thunbergii Bulbus: Traditional Uses, Phytochemistry, Pharmacodynamics, Pharmacokinetics and Toxicity

“…FTB is considered a non-toxic or low toxic herb for the past several thousands of years with a recommended dose of 5−10 g (equivalent to 83–167 mg/kg body weight) for adults [2]. Recently, three included studies were published which are relevant to the toxicity of FTB [79,81,92]. An in vivo study using 110 male Wistar rats indicated that the FTB water extract (10 g/kg, ig, for seven days) did not increase the creatine kinase and lactate dehydrogenase levels compared to the saline group [79].…”

“…Recently, three included studies were published which are relevant to the toxicity of FTB [79,81,92]. An in vivo study using 110 male Wistar rats indicated that the FTB water extract (10 g/kg, ig, for seven days) did not increase the creatine kinase and lactate dehydrogenase levels compared to the saline group [79]. The histopathological examination in this study showed that the basic structure of heart tissue and cardiac muscle fibers were normal, compared to the saline group.…”

Artificial Intelligence vs. Natural Stupidity: Evaluating AI Readiness for the Vietnamese Medical Information System

“…In more advanced moves, a Chinese team used deep-learning algorithms to create an AI agent capable of accurately and efficiently supporting the screening of congenital cataracts as well as the treatment decisions by ophthalmologists across multiple hospitals [4]. Other AIM research projects coming from China have touched on the feasibility of using support vector machine model combined with metabonomics to check the safety of traditional Chinese medicine [43], or applying computational methods such as data mining to modernize traditional Chinese pharmacy [44,45,46,47]. By comparison, AIM studies in Japan show an advanced level in the physical branch, such as the successful robot assistance in thoracoscopic surgery [48], elderly care [49,50], or the health exercise demonstration robot TAIZO that can encourage more people to work out [51].…”

Study on Cardiotoxicity and Mechanism of “Fuzi” Extracts Based on Metabonomics

“…The active toxic alkaloids are liposoluble; thus, the DDA content in nonpolar solvent extracts is higher than that in aqueous solvent extracts. At present, there are few studies on the extraction of FZ alkaloids, most of which focus on extraction using boiling water or soaking, and extraction using alcoholic solvents [ 14 ].…”