A novel one-pot strategy to prepare β-cyclodextrin functionalized capillary monoliths for enantioseparation of basic drugs

Deng, Miaoduo; Li, Meng; Zhao, Yu; Jiang, Zhen; Guo, Xingjie

doi:10.1016/j.talanta.2018.07.041

Cited by 30 publications

(14 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A large amount of studies have suggested that CD and its derivatives are the most popular chiral additives because of relatively low price and properly sized cavity. For instance, the charged CDs are particularly well suited for oppositely charged analytes .…”

Section: Migration Time Resolution Selectivity Factor and Column Ementioning

confidence: 99%

Investigation of deep eutectic solvents as additives to β‐CD for enantiomeric separations of Zopiclone, Salbutamol, and Amlodipine by CE

Huang

et al. 2019

Electrophoresis

View full text Add to dashboard Cite

The enantioseparation of chiral drugs via CE was first investigated using β‐CD as chiral additive and deep eutectic solvents (DESs) as auxiliary additive. The results showed that improved separation of tested chiral drugs was obtained in the presence of DESs and β‐CD compared to the single β‐CD separation system. With the optimized condition, resolutions of DESs applied β‐CD separation system for rac‐Zopiclone, rac‐Salbutamol, and rac‐Amlodipine increased 3–4.2 times as single β‐CD separation system. The resolutions reached 4.74, 6.37, and 9.67, respectively. The results demonstrate that DESs are viable additives to CD system in CE for the separation of the chiral drugs.

show abstract

Section: Migration Time Resolution Selectivity Factor and Column Ementioning

confidence: 99%

Investigation of deep eutectic solvents as additives to β‐CD for enantiomeric separations of Zopiclone, Salbutamol, and Amlodipine by CE

Huang

et al. 2019

Electrophoresis

View full text Add to dashboard Cite

show abstract

“…In recent years, there are many studies for the enantiomer separations based on the β‐cyclodextrin (β‐CD) or protein‐modified monolithic capillary columns . It is well‐known that β‐CD is the product of the enzymatic degradation of starch with seven glucose rings and has a doughnut‐like annular structure with wide and narrow hydrophilic ends , β‐CD and its derivatives are regarded as outstanding chiral selectors that are widely applied in various chromatographic analysis.…”

Section: Monolithic Capillary Electrochromatographymentioning

confidence: 99%

Recent developments of monolithic and open‐tubular capillary electrochromatography (2017–2019)

Yin

Zhang

et al. 2020

J of Separation Science

View full text Add to dashboard Cite

Capillary electrochromatography, which combined the high selectivity of highperformance liquid chromatography and the high separation efficiency of capillary electrophoresis, is an attractive separation tool. In this review, the developments on monolithic and open tubular capillary electrochromatography during 2017 to August 2019 are summarized. Considering the development of novel stationary phases is the most active research field in capillary electrochromatography, monolithic capillary electrochromatography is classified according to the polymer-based and hybrid monolithic columns, while open-tubular capillary electrochromatography is categorized by cyclodextrin, silica, polymer, nanomaterials, microporous materials, and biomaterials-based open tubular columns. K E Y W O R D S

show abstract

“…However, CDs in the mobile phase result in relatively low sensitivity with a high consumption of chemicals. Since the discovery of the advantageous property of monoliths, attempts have been made to explore β‐CD‐based monolithic stationary phase for enantiomer separation 19–26 . With the promising development, new CD derivatives functionalized monoliths need to be prepared in order to achieve altered enantioselectivities and further broaden the application range.…”

Section: Introductionmentioning

confidence: 99%

Preparation of a novel hydroxypropyl‐γ‐cyclodextrin functionalized monolith for separation of chiral drugs in capillary electrochromatography

et al. 2021

Self Cite

View full text Add to dashboard Cite

In this study, a novel hydroxypropyl‐γ‐cyclodextrin (HP‐γ‐CD) functionalized monolithic capillary column was prepared by one‐pot sequential strategy and used for chiral separation in capillary electrochromatography for the first time. In one pot, GMA‐HP‐γ‐CD as functional monomer was allowed to be formed via the ring opening reaction between HP‐γ‐CD and glycidyl methacrylate (GMA) catalyzed by 1,8‐diazabicyclo[5.4.0]undec‐7‐ene (DBU) and then copolymerized directly with ethylene dimethacrylate (EDMA) and 2‐acrylamido‐2‐methyl propane sulfonic acid (AMPS) in the presence of porogenic solvents via thermally initiated free radical polymerization. The preparation conditions of monoliths were optimized. Enantiomer separations of six chiral drugs including pindolol, clorprenaline, tulobuterol, clenbuterol, propranolol, and tropicamide were achieved on the monolith. Among them, pindolol, clorprenaline, and tropicamide were baseline separated with resolution values of 1.62, 1.73, and 1.55, respectively. The mechanism of enantiomer separation was discussed by comparison of the HP‐γ‐CD and HP‐β‐CD functionalized monoliths.

show abstract

A novel one-pot strategy to prepare β-cyclodextrin functionalized capillary monoliths for enantioseparation of basic drugs

Cited by 30 publications

References 29 publications

Investigation of deep eutectic solvents as additives to β‐CD for enantiomeric separations of Zopiclone, Salbutamol, and Amlodipine by CE

Investigation of deep eutectic solvents as additives to β‐CD for enantiomeric separations of Zopiclone, Salbutamol, and Amlodipine by CE

Recent developments of monolithic and open‐tubular capillary electrochromatography (2017–2019)

Preparation of a novel hydroxypropyl‐γ‐cyclodextrin functionalized monolith for separation of chiral drugs in capillary electrochromatography

Contact Info

Product

Resources

About