“…On the other hand, one should bear in mind that the immune system is also under the influence of the laser 17,20 . Some authors suggest that immune cells against the HSV-1 virus are also proliferating, and they are active against a viral infection 21,22 . De Carvalho et al 21 used laser independently of the stage of the disease and the results showed the reduction of edema, and the size of the lesion.…”